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    Functional synthetic molecules and macromolecules for gene delivery
    1.
    发明授权
    Functional synthetic molecules and macromolecules for gene delivery 失效
    用于基因递送的功能性合成分子和大分子

    公开(公告)号：US07507859B2

    公开(公告)日：2009-03-24

    申请号：US10559349

    申请日：2004-06-16

    申请人： Mark W. Grinstaff ,  Philippe Barthelemy ,  Carla Prata ,  Louis Moreau

    发明人： Mark W. Grinstaff ,  Philippe Barthelemy ,  Carla Prata ,  Louis Moreau

    IPC分类号： C07C233/00 ,  C07C211/00 ,  C07C229/00

    CPC分类号： C12N15/88 ,  A61K47/542 ,  A61K47/549 ,  A61K47/58 ,  A61K47/593 ,  A61K47/60 ,  A61K48/0025 ,  C07C219/06 ,  C07C233/36 ,  C07C271/22 ,  C07D311/16 ,  C07H19/12

    摘要： The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.

    摘要翻译： 本发明描述了用于基因治疗的合成非病毒载体组合物和用于遗传物质的体外，离体和/或体内转移的这些组合物。 本发明提出一种药物组合物，其含有1）非阳离子两亲性分子或大分子及其用于递送核酸的用途，或2）阳离子两亲分子或大分子，其通过以下方式从阳离子实体转变为阴离子，中性或两性离子的实体： 化学，光化学或生物反应及其用于递送核酸的用途。 此外，本发明描述了这些非病毒载体组合物与表面结合以介导核酸递送的用途。 另外的实施方案是用这些组合物形成水凝胶，以及使用该水凝胶来输送遗传物质。 本发明的另一个实施方案是使用离子强度的变化来传递遗传物质。

    Method for preparing a pharmaceutical composition with modified release of the active principle, comprising a matrix
    3.
    发明授权
    Method for preparing a pharmaceutical composition with modified release of the active principle, comprising a matrix 有权
    制备具有改性释放活性成分的药物组合物的方法，包括基质

    公开(公告)号：US06194005B1

    公开(公告)日：2001-02-27

    申请号：US09269468

    申请日：1999-03-23

    申请人： Nabil Farah ,  Philippe Barthelemy ,  Joseph Joachim

    发明人： Nabil Farah ,  Philippe Barthelemy ,  Joseph Joachim

    IPC分类号： A61K922

    CPC分类号： A61K9/2013 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/2009 ,  A61K9/2077 ,  A61K9/5015

    摘要： The invention concerns a method for preparing a modified release of active principle. The method comprises the steps of mixing a powder composed of active principle, adjuvant or combinations thereof while heating and fluidizing in order to obtain individual grains, liquefying a lipid matrix agent composed of partial esters of alcohol with at least one fatty acid, coating the powder by spraying from 1 to 15% by weight of the final composition liquid lipid matrix agent over the individual grains, the spraying air pressure, and optionally the spraying rate varying throughout the coating operation and lowering the temperature of the combined product to allow the lipid matrix agent to solidify around the grains.

    摘要翻译： 本发明涉及制备活性成分的改性释放的方法。 该方法包括以下步骤：将由活性成分组成的粉末，佐剂或其组合混合，同时加热和流化以获得单个颗粒，将由醇的偏酯与至少一种脂肪酸组成的脂质基质剂液化， 通过在单个颗粒上喷雾1至15重量％的最终组合物液体脂质基质剂，喷雾空气压力和任选的喷雾速率在整个涂布操作中变化并降低组合产物的温度，以允许脂质基质 药剂在谷物周围固化。

    Composition with sustained release of active principle, capable of forming a microemulsion
    6.
    发明授权
    Composition with sustained release of active principle, capable of forming a microemulsion 有权
    具有持续释放活性成分的组合物，能够形成微乳液

    公开(公告)号：US06309665B2

    公开(公告)日：2001-10-30

    申请号：US09775782

    申请日：2001-02-02

    申请人： Philippe Barthelemy ,  Hassan Benameur

    发明人： Philippe Barthelemy ,  Hassan Benameur

    IPC分类号： A61K966

    CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K9/4866

    摘要： The invention concerns a composition comprising a microemulsion forming system by contact with a hydrophilic phase brought, after ingestion, by the physiological fluid, said microemulsion forming system comprising: at least an active principle; a lipophilic phase; a surfactant (TA); a co-surfactant (CoTA). The invention is characterized in that said composition further comprises an inert polymeric matrix which cannot be ionised at physiological pH, dispersed in the microemulsion forming system before ingestion, said polymeric matrix being capable, after ingestion, of forming on contacting the physiological fluid, a gelled polymeric matrix enabling to release by diffusion, in continuous and prolonged manner the already micro-emulsified active principle.

    摘要翻译： 本发明涉及包含微乳液形成系统的组合物，所述组合物通过与由生理流体摄入后所带来的亲水相接触而形成，所述微乳液形成系统包括：至少一种活性成分; 亲脂相; 表面活性剂（TA）; 辅助表面活性剂（CoTA）。 本发明的特征在于，所述组合物还包含惰性聚合物基质，其在生理pH下不能离子化，在摄入之前分散在微乳液形成体系中，所述聚合物基质在摄入后能够在接触生理流体时形成凝胶 聚合物基质能够以连续和延长的方式通过扩散释放已经微乳化的活性成分。

    Circuit for supplying a control contact with power and application thereof to the control of a rest time delay of a relay
    7.
    发明授权
    Circuit for supplying a control contact with power and application thereof to the control of a rest time delay of a relay 失效
    用于向控制触点提供电力及其应用以控制继电器的休止时间延迟的电路

    公开(公告)号：US4480194A

    公开(公告)日：1984-10-30

    申请号：US466192

    申请日：1983-02-14

    申请人： Philippe Barthelemy ,  Gilles Baurand ,  Francois Roussel

    发明人： Philippe Barthelemy ,  Gilles Baurand ,  Francois Roussel

    IPC分类号： H01H1/60 ,  H01H9/54 ,  H01H47/00 ,  H01H47/18

    CPC分类号： H01H1/605 ,  H01H47/18 ,  Y10T307/878 ,  Y10T307/944 ,  Y10T307/957

    摘要： With this circuit, a current may be caused to flow through a contact (K) controlling the voltage supply of an electronic control circuit (24), of sufficient intensity for the reliability of the contact to be good, without the current flowing in the control circuit (24) being too high and this independently of the supply voltage (terminals E, 44) applied to the supply terminals of the user circuit (U). For this, the control circuit (24) is fed with power when the contact (K) is closed, through said contact (K), a first diode (31) and a resistor (32) connected in series, whereas a piloting circuit (11), which is an integrated time delay or memory circuit associated with said user circuit (U), is then supplied through said contact (K) and a second diode (26). When contact (K) is open, said piloting circuit (11) is fed through a third diode (29) and a Zener diode (30), the second diode (26) then preventing the control circuit (24) from being supplied with power.

    摘要翻译： 利用该电路，可以使电流流过控制电子控制电路（24）的电压供应的触点（K），其具有足够的强度，以使触点的可靠性良好，而电流不会流入控制 电路（24）太高并且独立于施加到用户电路（U）的供电端子的电源电压（端子​​E，44）。 为此，当通过所述触点（K）闭合触点（K）时串联连接的第一二极管（31）和电阻器（32），控制电路（24）被馈送，而导频电路 然后通过所述触点（K）和第二二极管（26）提供与所述用户电路（U）相关联的集成的时间延迟或存储器电路（11）。 当接触（K）打开时，所述引导电路（11）通过第三二极管（29）和齐纳二极管（30）馈送，然后第二二极管（26）防止控制电路（24）被供电 。

    Process for treating liquid steels by injecting gas through the ladle bottom
    9.
    发明授权
    Process for treating liquid steels by injecting gas through the ladle bottom 失效
    通过将钢瓶底部注入气体来处理液态钢的方法

    公开(公告)号：US4957542A

    公开(公告)日：1990-09-18

    申请号：US366501

    申请日：1989-06-15

    申请人： Philippe Barthelemy ,  Christian Naturel

    发明人： Philippe Barthelemy ,  Christian Naturel

    IPC分类号： C21C7/00 ,  B22D1/00 ,  C21C7/072 ,  C22B9/05

    CPC分类号： C22B9/05 ,  B22D1/00 ,  C21C7/072

    摘要： A process for the in-ladle treatment of liquid steels by injecting gas through the ladle bottom. The process comprises injecting at least one inert gas from locations which are distributed over the ladle bottom in such a way as to form at the surface of the liquid steel an annular swelling, the outside edge of which is close to the inside edge of the lining of the wall of the ladle. An oxidizing gas may be mixed with the inert gas for decarburization. The process is applied in particular to the treatment of carbon steels.

    摘要翻译： 一种用于通过将钢瓶底部注入气体来进行液态钢的钢包处理的方法。 该方法包括从位于钢包底部分布的位置注入至少一种惰性气体，以便在液态钢的表面形成环状膨胀，其外边缘靠近衬里的内边缘 的钢包的墙壁。 可以将氧化气体与惰性气体混合以进行脱碳。 该方法特别用于碳钢的处理。