公开(公告)号：US08722412B2

公开(公告)日：2014-05-13

申请号：US13338289

申请日：2011-12-28

申请人： Markus Egle ,  Stefan Thiem ,  Simon Keimer ,  Karl-Heinz Westerhoff

发明人： Markus Egle ,  Stefan Thiem ,  Simon Keimer ,  Karl-Heinz Westerhoff

IPC分类号： G01N35/00 ,  G01N1/31

CPC分类号： G01N35/00732 ,  G01N1/312 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/34 ,  Y10T436/112499

摘要： An apparatus for sensing specimen slides (38) has a specimen slide holder (42) holding specimen slides (38), each specimen slide (38) comprising an identification code. The specimen slides (38) are arranged inside the specimen slide holder (42) on a lifting element (50) in a lifted position. The apparatus includes a reading apparatus (40) for reading out the identification code, and a positioning apparatus that moves the specimen slide holder (42) with the specimen slides (38) relative to the lifting element (50) so that the specimen slides (38) drop successively from the lifted position on the lifting element (50). As one of the specimen slides (38) drops, the identification code of the specimen slide (38) or of the subsequent specimen slide (38) becomes readable for the reading apparatus (40). A triggering apparatus (67, 68) triggers the reading apparatus (40) to read the identification code.

摘要翻译： 一种用于感测标本片（38）的装置，具有夹持标本片（38）的标本片保持架（42），每个标本片（38）包括识别码。 试样滑动件（38）被布置在提升元件（50）的提升位置内的试样滑动架（42）的内部。 该装置包括用于读出识别码的读取装置（40），以及使样本滑块（38）相对于提升元件（50）移动的试样滑动架（42）的定位装置，使试样滑动 38）从升降元件（50）上的提升位置依次下降。 当标本片（38）中的一个下降时，对于读取装置（40），样本滑块（38）或随后的标本滑块（38）的识别码变得可读。 触发装置（67,68）触发读取装置（40）读取识别码。

公开(公告)号：US07910060B2

公开(公告)日：2011-03-22

申请号：US12559112

申请日：2009-09-14

申请人： Simon Keimer ,  Harald Rauh ,  Eberhard Sendobry ,  Jürgen Tenhaef ,  Stefan Thiem

发明人： Simon Keimer ,  Harald Rauh ,  Eberhard Sendobry ,  Jürgen Tenhaef ,  Stefan Thiem

IPC分类号： G01N21/00

CPC分类号： G01N1/31 ,  G01N35/1002 ,  Y10T436/2575

摘要： An apparatus is described for treating prepared specimens. The apparatus comprises at least two container rows arranged in parallel to each other, each comprising a plurality of reagent containers and a transport mechanism for transporting at least one transport container that receives at least one carrier holding at least one prepared specimen. The transport mechanism is movable along an X and Z axis. A rotation unit is provided comprising holding arms and at least one holding element. The container rows are received rotatably at the ends of the holding arms of the at least one holding element that is connected to a rotation shaft such that it co-rotates with the rotation shaft that extends parallel to the X axis. The rotation unit is adapted to assume at least one working position allowing the transport mechanism to have access to the reagent container.

摘要翻译： 描述了一种用于处理制备的样品的装置。 该装置包括彼此平行布置的至少两个容器排，每个容器行包括多个试剂容器和用于输送至少一个容纳至少一个保持有至少一个准备样品的载体的运送容器的运送机构。 传送机构可沿X轴和Z轴移动。 提供了旋转单元，其包括保持臂和至少一个保持元件。 容器列可旋转地容纳在连接到旋转轴的至少一个保持元件的保持臂的端部处，使得其与平行于X轴延伸的旋转轴共旋转。 旋转单元适于呈现至少一个工作位置，允许输送机构进入试剂容器。

公开(公告)号：US20100068094A1

公开(公告)日：2010-03-18

申请号：US12559112

申请日：2009-09-14

申请人： Simon Keimer ,  Harald Rauh ,  Eberhard Sendobry ,  Jürgen Tenhaef ,  Stefan Thiem

发明人： Simon Keimer ,  Harald Rauh ,  Eberhard Sendobry ,  Jürgen Tenhaef ,  Stefan Thiem

IPC分类号： G01N33/00

CPC分类号： G01N1/31 ,  G01N35/1002 ,  Y10T436/2575

摘要： An apparatus is described for treating prepared specimens. The apparatus comprises at least two container rows arranged in parallel to each other, each comprising a plurality of reagent containers and a transport mechanism for transporting at least one transport container that receives at least one carrier holding at least one prepared specimen. The transport mechanism is movable along an X and Z axis. A rotation unit is provided comprising holding arms and at least one holding element. The container rows are received rotatably at the ends of the holding arms of the at least one holding element that is connected to a rotation shaft such that it co-rotates with the rotation shaft that extends parallel to the X axis. The rotation unit is adapted to assume at least one working position allowing the transport mechanism to have access to the reagent container.

摘要翻译： 描述了一种用于处理制备的样品的装置。 该装置包括彼此平行布置的至少两个容器排，每个包括多个试剂容器和用于运输至少一个运送容器的运输机构，该输送容器容纳至少一个容纳至少一个制备的样品的载体。 传送机构可沿X轴和Z轴移动。 提供了旋转单元，其包括保持臂和至少一个保持元件。 容器列可旋转地容纳在连接到旋转轴的至少一个保持元件的保持臂的端部处，使得其与平行于X轴延伸的旋转轴共旋转。 旋转单元适于呈现至少一个工作位置，允许输送机构进入试剂容器。

公开(公告)号：US20090235799A1

公开(公告)日：2009-09-24

申请号：US11577726

申请日：2005-10-15

申请人： Stefan Thiem

发明人： Stefan Thiem

IPC分类号： B26D1/00

CPC分类号： G01N1/06 ,  B26D1/06 ,  B26D7/2614 ,  G01N2001/061 ,  Y10S83/01 ,  Y10S83/954 ,  Y10T83/6492 ,  Y10T83/6584 ,  Y10T83/929 ,  Y10T83/9457 ,  Y10T83/9493

摘要： A knife holder (1) for microtome blades (2) is described, which holder has a body (3) for reception of the blade (2) against an abutment edge (4) and a pressure plate (5) for retention of the blade, such that in the retained state, only the blade cutting edge (6) protrudes from the body (3), and an ejection apparatus (8), associated with one side edge (7) of the blade cutting edge (6), is arranged on the body (3).

摘要翻译： 描述了一种用于切片机叶片（2）的刀架（1），该夹具具有用于接收刀片（2）抵靠边缘（4）的主体（3）和用于保持刀片的压板（5） 使得在保持状态下，只有刀片切割刃（6）从主体（3）突出，并且与刀片切割刃（6）的一个侧边缘（7）相关联的喷射装置（8）是 布置在身体（3）上。

公开(公告)号：US06635225B1

公开(公告)日：2003-10-21

申请号：US09542873

申请日：2000-04-04

申请人： Stefan Thiem ,  Ralf Kaltenmeier ,  Eric Barth ,  Joachim Glasenapp ,  Stefan Kunkel

发明人： Stefan Thiem ,  Ralf Kaltenmeier ,  Eric Barth ,  Joachim Glasenapp ,  Stefan Kunkel

IPC分类号： G01N3504

CPC分类号： G01N1/312 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165

摘要： An automatic stainer for staining objects, arranged on slides for microscopic examination is described. The automatic stainer has multiple reagent containers arranged one behind another for treating the objects. The slides pass through the reagent containers in succession, a transport basket for receiving multiple slides being provided. Multiple transport baskets can be received simultaneously in respective different reagent containers, and are simultaneously lifted out of the respective reagent container by way of a motorized transport mechanism having a lifting device and are respectively transported on into an adjacent reagent container. A removal station that has a collecting reagent container for the simultaneous reception of multiple transport baskets is arranged at the end of the row of reagent containers.

摘要翻译： 描述了用于染色物体的自动染色剂，布置在用于显微镜检查的载玻片上。 自动染色机具有一个彼此排列的多个试剂容器用于处理物体。 滑块连续穿过试剂容器，提供用于接收多个载玻片的运输篮。 可以在各个不同的试剂容器中同时接收多个运送篮，并且通过具有提升装置的电动运输机构同时从相应的试剂容器中提出，并分别运送到相邻的试剂容器中。 具有用于同时接收多个运送篮的收集试剂容器的移除站布置在该行试剂容器的末端。

公开(公告)号：US06858183B2

公开(公告)日：2005-02-22

申请号：US09931600

申请日：2001-08-16

申请人： Stefan Thiem ,  Stefan Kuenkel ,  Eric Barth

发明人： Stefan Thiem ,  Stefan Kuenkel ,  Eric Barth

IPC分类号： G01N33/48 ,  G01N1/30 ,  G01N1/31 ,  G01N1/34 ,  G01N35/00

CPC分类号： G01N1/31 ,  G01N2001/315 ,  Y10T436/11 ,  Y10T436/112499

摘要： An apparatus for treating objects, in particular cytological or histological specimens, having multiple processing stations and a transport device for delivering the objects into and out of the processing stations, is characterized in that at least one running-water station (1), having an inflow (2) and an outflow (3), is provided as a processing station.

摘要翻译： 一种用于处理具有多个处理站的物体（特别是细胞学或组织学标本）的装置，其特征在于，至少一个流水站（1）具有 流入（2）和流出（3）作为处理站。

公开(公告)号：US6080365A

公开(公告)日：2000-06-27

申请号：US972732

申请日：1997-11-18

申请人： Stefan Thiem ,  Eric Barth

发明人： Stefan Thiem ,  Eric Barth

IPC分类号： G01N1/36 ,  B01L3/00 ,  B01L11/00 ,  B32B27/04

CPC分类号： G01N1/36

摘要： A description is given of an automatic embedding machine (1) for treating samples for histological examinations, having a plurality of containers (4, 5) which are arranged one beside the other. The containers (4, 5) are each assigned an object holder (6), the object holders (6) being fastened on a turntable (7) provided over the containers (4, 5). The turntable (7) is connected to a central guide rod (8). The guide rod (8) is designed such that it can be moved perpendicularly with respect to the direction of rotation of the turntable (7). A vacuum device (9) for producing a vacuum in at least one of the containers (4, 5) is integrated in the automatic embedding machine (1).

摘要翻译： 给出了一种用于处理用于组织学检查的样品的自动包埋机（1）的描述，其具有彼此排列的多个容器（4,5）。 容器（4,5）中的每一个分配有物体保持器（6），物体保持器（6）紧固在设置在容器（4,5）上的转盘（7）上。 转盘（7）连接到中心导杆（8）。 引导杆（8）被设计成使其能够相对于转盘（7）的旋转方向垂直移动。 用于在至少一个容器（4,5）中产生真空的真空装置（9）集成在自动包埋机（1）中。

公开(公告)号：US6058788A

公开(公告)日：2000-05-09

申请号：US974236

申请日：1997-11-19

申请人： Stefan Thiem ,  Bernd Guenther

发明人： Stefan Thiem ,  Bernd Guenther

IPC分类号： G01N1/31 ,  G01N1/36 ,  G01N1/00

CPC分类号： G01N1/36 ,  G01N1/31

摘要： A description is given of a drive device for an automatic embedding machine (1) for treating samples (17) for histological examinations, having a plurality of containers (4, 5) which are arranged one beside the other and are each assigned an object holder (6). The object holders (6) are fastened, on a lifting device (18), over the containers (4, 5), the lifting device (18) having a turntable (7) and a rotatably mounted guide rod (8). The guide rod (8) is designed such that it can be moved by a motor, perpendicularly with respect to the direction of rotation of the turntable (7), via the lifting device (18). Provided for the purpose of driving the guide rod (8) is an open-ended, flexibly designed drive element (21) which, at its first end, is arranged between two rollers (26, 27) of the motor drive (20) and, by means of its second end, is connected fixedly to the housing (24) of the automatic embedding machine (1). The second end of the drive element (21) is guided over a deflection roller (19) and forms a loop (28) for receiving the guide rod (8).

摘要翻译： 给出了一种用于处理用于组织学检查的样品（17）的自动包埋机（1）的驱动装置，其具有多个彼此排列的容器（4,5），并且分别被分配一个物体保持器 （6）。 物体保持器（6）在提升装置（18）上紧固在容器（4,5）上，提升装置（18）具有转盘（7）和可旋转地安装的导杆（8）。 引导杆（8）被设计成使得其可以通过电动机通过提升装置（18）相对于转台（7）的旋转方向垂直移动。 为了驱动导杆（8）的目的是提供一种开放式，灵活设计的驱动元件（21），其驱动元件（21）在其第一端处布置在电机驱动器（20）的两个辊（26,27）之间，并且 通过其第二端固定地连接到自动包埋机（1）的壳体（24）上。 驱动元件（21）的第二端被引导在偏转辊（19）上并且形成用于接收导杆（8）的环（28）。

公开(公告)号：US5711200A

公开(公告)日：1998-01-27

申请号：US536284

申请日：1995-09-29

申请人： Stefan Thiem

发明人： Stefan Thiem

IPC分类号： G01N1/06 ,  G01N1/28 ,  G02B21/32

CPC分类号： G01N1/06 ,  Y10T83/283

摘要： A housing for a microtome which is capable of being employed in a cryostat. The microtome housing includes a waterproof microtome chamber having an elongate slot formed in the wall thereof through which an object holding device extends. The elongate slot has a seal disposed about its periphery and the slot is covered by a coverplate which is provided adjacent to the seal. The coverplate is rotatable about the axis of a pin which is provided on the interior of the chamber wall. The chamber further includes magnets which are arranged on the wall of the chamber adjacent to the elongate slot such that the magnets retain the coverplate over the elongate slot. This arrangement allows the object holding device to be easily inserted into and removed from the chamber, while at the same time maintaining substantially moisture free conditions within the chamber.

摘要翻译： 用于切片机的壳体，其能够用于低温恒温器。 切片机壳体包括防水切片机室，其具有形成在其壁中的细长槽，物体保持装置通过其延伸。 细长槽具有围绕其周边设置的密封件，并且狭槽由与密封件相邻设置的盖板覆盖。 盖板可围绕设置在室壁内部的销的轴线旋转。 所述腔室还包括布置在所述腔室的与所述细长槽相邻的壁上的磁体，使得所述磁体将所述盖板保持在所述细长槽上。 这种布置允许物体保持装置容易地插入到腔室中并从腔室中移除，同时在腔室内保持基本上无水分的条件。

公开(公告)号：US20100180742A1

公开(公告)日：2010-07-22

申请号：US12602183

申请日：2008-06-06

申请人： Roland Walter ,  Stefan Thiem ,  Andreas Laudat

发明人： Roland Walter ,  Stefan Thiem ,  Andreas Laudat

IPC分类号： G01N1/06 ,  B26D5/20

CPC分类号： G01N1/06 ,  G01N2001/065 ,  Y10T83/04 ,  Y10T83/141 ,  Y10T83/626 ,  Y10T83/6569

摘要： The present invention relates to a device for braking or locking a shaft (6) of a microtome (1). The microtome (1) comprises the shaft (6), an actuating element (2), a movement mechanism (37) and a housing (38). With the movement mechanism (37) an object to be cut can be moved relative to a knife blade. The actuating element (2) can be manually actuated by an operator. As a result thereof, the shaft (6) can be rotated. Via the shaft (6), the movement mechanism (37) for performing the relative motion between the object and the knife blade can be driven. Further, the present invention relates to a method for operating a device for braking a shaft (6) of a microtome (1). So that the device can be used in a mechanically formed movement mechanism (37), the inventive device is characterized by an actuator and a braking unit (25). The braking unit (25) is connected in a rotatably fixed manner to the shaft (6). With the actuator, the braking unit (25) can be automatically placed in a brake position in which the shaft (6) can be connected in a rotatably fixed manner to the housing (11).

摘要翻译： 本发明涉及一种用于制动或锁定切片机（1）的轴（6）的装置。 切片机（1）包括轴（6），致动元件（2），移动机构（37）和壳体（38）。 利用移动机构（37），待切割的物体可以相对于刀片移动。 致动元件（2）可由操作者手动致动。 结果，轴（6）可以旋转。 通过轴（6），可以驱动用于执行物体和刀片之间的相对运动的移动机构（37）。 此外，本发明涉及一种操作用于制造切片机（1）的轴（6）的装置的方法。 因此，该装置可以用于机械地形成的运动机构（37）中，本发明的装置的特征在于致动器和制动单元（25）。 制动单元（25）以可旋转地固定的方式连接到轴（6）。 通过致动器，制动单元（25）可以自动地放置在制动位置，在该制动位置中，轴（6）可以以可旋转地固定的方式连接到壳体（11）。