公开(公告)号：US20100234531A1

公开(公告)日：2010-09-16

申请号：US12789644

申请日：2010-05-28

Applicant: Markus FRANK

Inventor： Markus FRANK

IPC: C08F8/00

CPC classification number: C08J3/12 ,  B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28014 ,  B01J20/3028 ,  B01J20/3042 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/3208 ,  B01J20/3223 ,  B01J20/327 ,  B01J20/3282 ,  B01J2220/56 ,  B01J2220/68 ,  C08J2300/14 ,  Y10T428/254 ,  Y10T428/2985 ,  Y10T428/2987

Abstract: Among other things, a process for producing an agglomerated superabsorbent polymer particle and an agglomerated superabsorbent polymer particle are disclosed. The process comprises the steps of: (A) bringing superabsorbent polymer fine particles having at least about 40 wt. %, a particle size of less than about 150 μm into contact with a fluid comprising to more than about 10 wt. % a cross-linkable, uncrosslinked polymer based on polymerized, ethylenically unsaturated, acid group-bearing monomers or salts thereof; and (B) cross-linking the uncrosslinked polymer by heating the superabsorbent polymer fine particles and the fluid to a temperature from about 20 to about 300° C., so that the cross-linkable, uncrosslinked polymer at least partially crosslinks.

Abstract translation: 其中，公开了一种生产聚集超吸收聚合物颗粒和聚集的超吸收聚合物颗粒的方法。 该方法包括以下步骤：（A）使超吸收性聚合物细颗粒具有至少约40wt。 ％，小于约150μm的颗粒尺寸与包含至多约10重量％ 基于聚合的烯属不饱和的含酸基单体或其盐的可交联的未交联的聚合物; 和（B）通过将超吸收性聚合物细颗粒和流体加热至约20至约300℃的温度来交联未交联的聚合物，使得可交联的未交联的聚合物至少部分交联。

公开(公告)号：US20140135307A1

公开(公告)日：2014-05-15

申请号：US14160646

申请日：2014-01-22

Applicant: Markus FRANK ,  Hans HAEBERLE ,  Manuel HENRY ,  Thorsten PACHUR ,  Marco SANTAGOSTINO ,  Uwe STERTZ ,  Thomas TREBING ,  Ulrike WERTHMANN

Inventor： Markus FRANK ,  Hans HAEBERLE ,  Manuel HENRY ,  Thorsten PACHUR ,  Marco SANTAGOSTINO ,  Uwe STERTZ ,  Thomas TREBING ,  Ulrike WERTHMANN

IPC: C07D401/14

Abstract: This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

Abstract translation: 本发明涉及式1的CCR3抑制剂的共晶和盐，含有它的药物组合物及其用作治疗和/或预防与CCR3受体有关的疾病的药剂的方法。

公开(公告)号：US20100210842A1

公开(公告)日：2010-08-19

申请号：US12702097

申请日：2010-02-08

Applicant: Adil DURAN ,  Markus FRANK ,  Waldemar PFRENGLE ,  Juergen SCHNAUBELT

Inventor： Adil DURAN ,  Markus FRANK ,  Waldemar PFRENGLE ,  Juergen SCHNAUBELT

IPC: C07D295/155 ,  C07C311/19

CPC classification number: C07D295/135 ,  C07C311/29

Abstract: The present invention relates to a method of preparing compounds of general formula I wherein m, n, R1 and R2 are defined as mentioned hereinafter, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases.

Abstract translation: 本发明涉及一种制备通式I化合物的方法，其中m，n，R 1和R 2如下文所定义，其对映体，非对映异构体，混合物及其盐，特别是其生理上可接受的盐与有机或 无机酸或碱。

公开(公告)号：US20150087829A1

公开(公告)日：2015-03-26

申请号：US14494631

申请日：2014-09-24

Applicant: Georg DAHMANN ,  Holger WAGNER ,  Matthias ECKHARDT ,  Markus FRANK ,  Marco SANTAGOSTINO ,  Juergen SCHNAUBELT ,  Uwe STERTZ ,  Thorsten PACHUR

Inventor： Georg DAHMANN ,  Holger WAGNER ,  Matthias ECKHARDT ,  Markus FRANK ,  Marco SANTAGOSTINO ,  Juergen SCHNAUBELT ,  Uwe STERTZ ,  Thorsten PACHUR

IPC: C07D307/80 ,  C07D405/12 ,  C07D513/04 ,  C07D407/12

CPC classification number: C07D307/80 ,  C07D405/12 ,  C07D407/12 ,  C07D513/04

Abstract: The present invention relates to compounds of formula I wherein RS denotes F or CF3, Ra denotes H or C1-4-alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

Abstract translation: 本发明涉及式I化合物，其中RS表示F或CF 3，R a表示H或C 1-4 - 烷基，Z表示离去基团或任选取代或保护的羟基，适合于合成二氢氧化二氢苯并呋喃基乙酸的中间体， 其是GPR40激动剂，涉及制备这些中间体的方法和制备在过渡金属催化剂和手性助剂存在下使用不对称催化氢化反应的GPR40激动剂的方法。

公开(公告)号：US20130184204A1

公开(公告)日：2013-07-18

申请号：US13548233

申请日：2012-07-13

Applicant: Waldemar PFRENGLE ,  Markus FRANK ,  Thomas KLEIN

Inventor： Waldemar PFRENGLE ,  Markus FRANK ,  Thomas KLEIN

IPC: C07D473/04 ,  A61K31/4439 ,  A61K31/155 ,  A61K31/522 ,  A61K45/06

CPC classification number: C07D473/06 ,  A61K31/155 ,  A61K31/4439 ,  A61K31/522 ,  A61K45/06 ,  C07D473/04

Abstract: The present invention relates to substituted quinazolines of formula (I): wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract translation: 本发明涉及式（I）的取代喹唑啉：其中X和Y如权利要求1所定义，其互变异构体，立体异构体，混合物和盐具有有价值的药理学性质，特别是对酶活性的抑制作用 二肽基肽酶-IV（DPP-IV）。