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公开(公告)号：US07323175B2
公开(公告)日：2008-01-29
申请号：US10383930
申请日：2003-03-07
申请人： Daniel J. Smith , Martin A. Taubman
发明人： Daniel J. Smith , Martin A. Taubman
CPC分类号： C07K16/1278 , A61K39/092 , C07K14/315
摘要： Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.
摘要翻译： 描述了用于龋齿的免疫原性组合物和亚单位疫苗，其包含葡聚糖结合蛋白B的肽亚基和葡聚糖结合蛋白B的肽亚基与葡糖基转移酶的肽亚基的组合。 引发对变形链球菌葡聚糖结合蛋白B或葡糖基转移酶的免疫应答的方法。 还描述了免疫哺乳动物抵抗龋齿的方法，以及结合葡聚糖结合蛋白B或葡糖基转移酶的特定表位的抗体。
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公开(公告)号：US07163682B2
公开(公告)日：2007-01-16
申请号：US10797821
申请日：2004-03-09
申请人： Daniel J. Smith , Martin A. Taubman
发明人： Daniel J. Smith , Martin A. Taubman
CPC分类号： C07K14/315 , A61K39/00 , A61K39/092 , A61K2039/645 , C07K16/1275 , C07K16/1278 , C07K16/40
摘要： Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.
摘要翻译： 描述了用于龋齿的免疫原性组合物和亚单位疫苗，其包含葡聚糖结合蛋白B的肽亚基和葡聚糖结合蛋白B的肽亚基与葡糖基转移酶的肽亚基的组合。 引发对变形链球菌葡聚糖结合蛋白B或葡糖基转移酶的免疫应答的方法。 还描述了免疫哺乳动物抵抗龋齿的方法，以及结合葡聚糖结合蛋白B或葡糖基转移酶的特定表位的抗体。
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公开(公告)号：US4250262A
公开(公告)日：1981-02-10
申请号：US103590
申请日：1979-12-14
申请人： Martin A. Taubman , Daniel J. Smith
发明人： Martin A. Taubman , Daniel J. Smith
CPC分类号： A61Q11/00 , A61K38/45 , A61K39/092 , A61K8/66 , C12N9/1051 , Y10S435/815 , Y10S435/885
摘要： Immunization of animals with preparations containing more purified forms of glucosyltransferase (GTF) results in the presence of antibody in saliva demonstrable by functional inhibitions of enzyme activity and binding of radioactive enzyme. Serum antibody was also present. Immunized groups of animals had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Local immunization with GTF of serotype c or g of a Streptococcus mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715) or c, or with serotype g or c, or with serotype a or g, respectively.
摘要翻译： 用含有更多纯化形式的葡糖基转移酶（GTF）的制剂对动物进行免疫导致在唾液中存在抗体，其可通过酶活性的功能性抑制和放射性酶的结合证实。 血清抗体也存在。 免疫组的动物平均龋分数比相对于假手术或非免疫对照组低。 使用血清型c或g变异链球菌的GTF进行的局部免疫减少了由血清型g（菌株6715）或c，或血清型g或c，或血清型a或c的变异链霉菌变异链球菌感染引起的定植，龋齿和损伤 g。
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公开(公告)号：US07101562B1
公开(公告)日：2006-09-05
申请号：US09562328
申请日：2000-05-01
申请人： Andrew Lees , Martin A. Taubman , Daniel J. Smith
发明人： Andrew Lees , Martin A. Taubman , Daniel J. Smith
IPC分类号： A61K39/09 , A61K39/02 , A61K39/385 , A61K39/116 , C07H1/00
CPC分类号： C12N9/1051 , A61K39/092 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/315 , C07K14/33 , Y10S424/831 , Y10S514/835 , Y10S530/806
摘要： The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.
摘要翻译： 本发明提供了基于葡聚糖的组合物和刺激针对变形链球菌组分的免疫应答的方法以及用于治疗和预防龋齿的疫苗和方法。 在优选的实施方案中，葡聚糖聚合物（优选WSG）与一种或多种T细胞依赖性抗原共价结合以形成缀合疫苗。 T细胞依赖性抗原优选含有一种或多种变形链球菌蛋白质的表位，例如葡糖基转移酶。 此外，一种或多种包括半抗原的部分可以与葡聚糖-T细胞依赖性组合物缀合。 在优选的实施方案中，这些部分是含有对应于变形链球菌的组分的免疫原性表位的肽。
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公开(公告)号：US07056517B2
公开(公告)日：2006-06-06
申请号：US10797302
申请日：2004-03-09
申请人： Daniel J. Smith , Martin A. Taubman
发明人： Daniel J. Smith , Martin A. Taubman
CPC分类号： C07K16/1278 , A61K39/00 , A61K39/092 , A61K2039/645 , C07K14/315 , C07K16/1275 , C07K16/40
摘要： Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, an equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.
摘要翻译： 描述了疫苗组合物和免疫原性组合物，其是用于龋齿的葡糖基转移酶亚单位疫苗，并且其含有至少一种肽，其对应于含有天冬氨酸413的葡萄糖基转移酶序列，相当于天冬氨酸413，天冬氨酸451，相当于天冬氨酸451，天冬氨酸562 ，相当于天冬氨酸562，天冬氨酸567，相当于天冬氨酸567，组氨酸561，相当于组氨酸561，色氨酸491，当量色氨酸491，谷氨酸489，当量谷氨酸489，精氨酸449，相当于精氨酸 449，或其组合。 这些亚单位疫苗引发了保护免疫哺乳动物免受龋齿的抗体。 还描述了引发对完整葡糖基转移酶的免疫应答的方法。
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公开(公告)号：US4150116A
公开(公告)日：1979-04-17
申请号：US879432
申请日：1978-02-21
申请人： Martin A. Taubman , Daniel J. Smith
发明人： Martin A. Taubman , Daniel J. Smith
CPC分类号： A61Q11/00 , A61K38/45 , A61K39/092 , A61K8/66
摘要： Immunization of animals with preparations containing more purified forms of glucosyltransferase (GTF) results in the presence of antibody in saliva demonstrable by functional inhibitions of enzyme activity and binding of radioactive enzyme. Serum antibody was also present. Immunized groups of animals had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Local immunization with GTF of serotype c or g or a Streptococcus mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715) or c, or with serotype g or c, or with serotype a or g, respectively.
摘要翻译： 用含有更多纯化形式的葡糖基转移酶（GTF）的制剂对动物进行免疫导致在唾液中存在抗体，其可通过酶活性的功能性抑制和放射性酶的结合证实。 血清抗体也存在。 免疫组的动物平均龋分数比相对于假手术或非免疫对照组低。 使用血清型c或g或变形链球菌的GTF进行局部免疫减少了血清型g（菌株6715）或c，或血清型g或c或与血清型a或c的变异链霉菌感染引起的定植，龋齿和损伤 g。
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公开(公告)号：US06827936B1
公开(公告)日：2004-12-07
申请号：US09290049
申请日：1999-04-12
申请人： Daniel J. Smith , Martin A. Taubman
发明人： Daniel J. Smith , Martin A. Taubman
IPC分类号： A61K3902
CPC分类号： C07K14/315 , A61K39/00 , A61K39/092 , A61K2039/645 , C07H21/04 , C07K16/1275 , C07K16/40
摘要： Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, and equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.
摘要翻译： 描述了疫苗组合物和免疫原性组合物，其是用于龋齿的葡糖基转移酶亚单位疫苗，并且其含有至少一种肽，其对应于含有天冬氨酸413的葡萄糖基转移酶序列，相当于天冬氨酸413，天冬氨酸451，相当于天冬氨酸451，天冬氨酸562 ，相当于天冬氨酸562，天冬氨酸567，相当于天冬氨酸567，组氨酸561，当量组氨酸561，色氨酸491，当量色氨酸491，谷氨酸489，当量谷氨酸489，精氨酸449，相当于精氨酸 449，或其组合。 这些亚单位疫苗引发了保护免疫哺乳动物免受龋齿的抗体。 还描述了引发对完整葡糖基转移酶的免疫应答的方法。
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公开(公告)号：US5686075A
公开(公告)日：1997-11-11
申请号：US57162
申请日：1993-04-30
申请人： Martin A. Taubman , Daniel J. Smith
发明人： Martin A. Taubman , Daniel J. Smith
CPC分类号： C12N9/1051 , A61K39/092 , A61K2039/6037 , C07K2319/00
摘要： Immunization of animals with a composition containing either an amino acid sequence from the catalytic domain of glucosyltransferase, an amino acid sequence from the glucan-binding region of glucosyltransferase or an amino acid sequence from the native surface domain of glucosyltransferase provoke antibody and T-cell immune responses to this enzyme. Since this enzyme has been implicated in the colonization of mutans streptococci on tooth surfaces, such immune responses are important for the prevention of dental caries. Multicomponent and multivalent compositions which include these amino acid sequences provide effective vaccine capabilities.
摘要翻译： 用含有来自葡糖基转移酶的催化结构域的氨基酸序列，葡糖基转移酶的葡聚糖结合区的氨基酸序列或来自葡糖基转移酶的天然表面结构域的氨基酸序列的组合物免疫动物，引发抗体和T细胞免疫 对这种酶的反应。 由于这种酶已经涉及牙齿表面上变形链球菌的定植，所以这种免疫应答对于预防龋齿是重要的。 包括这些氨基酸序列的多组分和多价组合物提供了有效的疫苗功能。
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公开(公告)号：US4438200A
公开(公告)日：1984-03-20
申请号：US416869
申请日：1982-09-13
申请人： Martin A. Taubman , Daniel J. Smith
发明人： Martin A. Taubman , Daniel J. Smith
CPC分类号： C12N9/1051 , Y10S435/814 , Y10S435/815
摘要： A method of preparing a purified glucosyltransferase (GTF) for use in immunization against dental caries, which method comprises: culturing a Streptococcus mutans in a medium containing glucose and dialyzable nutrients to form a mixture of culture cells and supernatant; recovering the supernatant by the removal of the culture cells; admixing the recovered supernatant with a water-insoluble, polymerized polysaccharide as solid particulate material for a period of time, to provide a GTF, solid particulate complex; recovering the GTF complex in solid particulate form by filtration; washing the solid GTF complex to remove unbound GTF and medium components; removing GTF from the solid particulate material by a denaturing solvent; recovering the water-insoluble particulate material for reuse in the method; and recovering the GTF from the water-insoluble polysaccharide and purifying the recovered GTF.
摘要翻译： 一种制备用于龋齿免疫的纯化葡糖基转移酶（GTF）的方法，该方法包括：在含有葡萄糖和透析营养物的培养基中培养变形链球菌以形成培养细胞和上清液的混合物; 通过去除培养细胞回收上清液; 将回收的上清液与水不溶性的聚合多糖作为固体颗粒材料混合一段时间，以提供GTF，固体颗粒复合物; 通过过滤回收固体颗粒形式的GTF复合物; 洗涤固体GTF复合物以去除未结合的GTF和介质组分; 通过变性溶剂从固体颗粒材料中除去GTF; 在该方法中回收不溶于水的颗粒物料以供再利用; 并从水不溶性多糖中回收GTF并纯化回收的GTF。
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公开(公告)号：US09801902B2
公开(公告)日：2017-10-31
申请号：US12087837
申请日：2007-01-17
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/7069 , A61K45/06 , A61K47/10 , A61K47/34 , A61L15/44 , A61L26/0066 , A61L2300/114
摘要： The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.
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