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9 条记录 (耗时 0.039 秒)

    Amyloid Beta 1-6 Antigen Arrays
    1.
    发明申请
    Amyloid Beta 1-6 Antigen Arrays 审中-公开
    淀粉样β1-6抗原阵列

    公开(公告)号：US20140294876A1

    公开(公告)日：2014-10-02

    申请号：US14105701

    申请日：2013-12-13

    申请人： Martin F. BACHMANN ,  Alain TISSOT ,  Rainer ORTMANN ,  Rainer LUEOEND ,  Matthias STAUFENBIEL ,  Peter FREY

    发明人： Martin F. BACHMANN ,  Alain TISSOT ,  Rainer ORTMANN ,  Rainer LUEOEND ,  Matthias STAUFENBIEL ,  Peter FREY

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0007 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复的抗原或抗原决定簇，特别是Aβ1-6P-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    CPG-PACKAGED LIPOSOMES
    4.
    发明申请
    CPG-PACKAGED LIPOSOMES 审中-公开
    CPG包装脂质体

    公开(公告)号：US20090074851A1

    公开(公告)日：2009-03-19

    申请号：US12171876

    申请日：2008-07-11

    申请人： Martin F. BACHMANN ,  Vania Manolova ,  Tazio Storni

    发明人： Martin F. BACHMANN ,  Vania Manolova ,  Tazio Storni

    IPC分类号： A61K9/127 ,  A61K31/7088 ,  A61P43/00

    CPC分类号： A61K39/39 ,  A61K9/127 ,  A61K2039/55555 ,  A61K2039/55561 ,  Y02A50/412

    摘要： Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFNα in vivo. These findings are relevant for the humans situation, since IFNα rather than IL-12 is the key cytokine for the induction of Th1 responses and anti-viral protection in humans.

    摘要翻译： 已知脂质体可增强触发IL-12产生的K-（B-）型CpG的活性。 在本发明中，令人惊奇的发现是，脂质体还增强D-（A-）型CpG的活性，导致体内IFNα的产生。 这些发现与人类情况相关，因为IFNalpha而不是IL-12是人类Th1应答诱导和抗病毒保护的关键细胞因子。

    MELAN-A-CARRIER CONJUGATES
    5.
    发明申请
    MELAN-A-CARRIER CONJUGATES 审中-公开
    梅兰运输公司

    公开(公告)号：US20110097417A1

    公开(公告)日：2011-04-28

    申请号：US12463985

    申请日：2009-05-11

    申请人： Martin F. BACHMANN ,  Vania Manolova ,  Edwin Meijerink ,  Karl G. Proba ,  Katrin Schwarz

    发明人： Martin F. BACHMANN ,  Vania Manolova ,  Edwin Meijerink ,  Karl G. Proba ,  Katrin Schwarz

    IPC分类号： A61K9/14 ,  A61K39/12 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K2039/5258 ,  A61K2039/55561 ,  A61K2039/6075 ,  A61K2039/62 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/4748 ,  C12N2710/22022 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2760/10022 ,  Y02A50/467

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP which can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs), and particular peptides derived from MelanA linked thereto. Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against MelanA peptide analogues optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against the MelanA peptide analogues are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含VLP的修饰病毒样颗粒（VLP），其可加载免疫刺激物质，特别是含有非甲基化C和G（CpG）的DNA寡核苷酸，以及衍生自与其连接的MelanA的特定肽。 这样的CpG-VLP比其不含CpG的对应物显着地更具免疫原性，并诱导增强的B和T细胞应答。 与VLP本身的免疫应答相似，对于任何偶联，融合或附着于VLP的MelanA肽类似物的免疫应答也相似地增强。 此外，针对MelanA肽类似物的T细胞应答特别针对Th1型。 因此，连接到CpG负载的VLP的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

    Hapten-Carrier Conjugates and Uses Thereof
    7.
    发明申请
    Hapten-Carrier Conjugates and Uses Thereof 审中-公开
    搭载运载体共轭体及其用途

    公开(公告)号：US20130142821A1

    公开(公告)日：2013-06-06

    申请号：US13476685

    申请日：2012-05-21

    申请人： Martin F. BACHMANN ,  Patrik Maurer

    发明人： Martin F. BACHMANN ,  Patrik Maurer

    IPC分类号： C07K17/02

    CPC分类号： C07K17/02 ,  A61K39/0013 ,  A61K39/385 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/6075 ,  C07K14/005 ,  C12N2730/10122 ,  C12N2795/18123

    摘要： The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

    摘要翻译： 本发明提供了包含有序和重复排列的半抗原与载体的缀合物的组合物，以及制备这种组合物的方法。 本发明的缀合物和组合物可以包含各种半抗原，包括激素，毒素和药物，特别是成瘾药物如尼古丁。 本发明的组合物和缀合物可用于诱导针对半抗原的免疫应答，其可用于各种治疗，预防和诊断方案中。 在某些实施方案中，使用本发明的缀合物，组合物和方法产生的免疫应答可用于预防或治疗滥用药物的成瘾以及与药物成瘾相关的所得疾病。