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    Methods and devices for analyte detection
    4.
    发明申请
    Methods and devices for analyte detection 有权
    用于分析物检测的方法和装置

    公开(公告)号：US20080009078A1

    公开(公告)日：2008-01-10

    申请号：US11725769

    申请日：2007-03-19

    申请人： Roger O'Neill ,  Marc Glazer ,  Tom Yang ,  Daniel Suich ,  Karl Voss

    发明人： Roger O'Neill ,  Marc Glazer ,  Tom Yang ,  Daniel Suich ,  Karl Voss

    IPC分类号： G01N33/566 ,  B05D3/00 ,  G01N33/00

    CPC分类号： G01N33/54366 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0668 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44726 ,  G01N27/44795 ,  G01N33/582

    摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.

    摘要翻译： 提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。 使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。 附件来自可触发事件，如光活化，热激活或化学活化。 根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。 因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。 分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。

    Methods and devices for analyte detection
    6.
    发明授权
    Methods and devices for analyte detection 有权
    用于分析物检测的方法和装置

    公开(公告)号：US09304133B2

    公开(公告)日：2016-04-05

    申请号：US13092595

    申请日：2011-04-22

    申请人： Roger A. O'Neill ,  Marc Glazer ,  Tom W. Yang ,  Daniel J. Suich ,  Karl O. Voss

    发明人： Roger A. O'Neill ,  Marc Glazer ,  Tom W. Yang ,  Daniel J. Suich ,  Karl O. Voss

    IPC分类号： G01N33/50 ,  G01N33/543 ,  B01L3/00 ,  G01N27/447 ,  G01N33/58

    CPC分类号： G01N33/54366 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0668 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44726 ,  G01N27/44795 ,  G01N33/582

    摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.

    摘要翻译： 提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。 使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。 附件来自可触发事件，如光活化，热激活或化学活化。 根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。 因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。 分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。

    METHODS AND DEVICES FOR ANALYTE DETECTION
    7.
    发明申请
    METHODS AND DEVICES FOR ANALYTE DETECTION 有权
    用于分析检测的方法和装置

    公开(公告)号：US20110195527A1

    公开(公告)日：2011-08-11

    申请号：US13092595

    申请日：2011-04-22

    申请人： Roger A. O'Neill ,  Marc Glazer ,  Tom W. Yang ,  Daniel J. Suich ,  Karl O. Voss

    发明人： Roger A. O'Neill ,  Marc Glazer ,  Tom W. Yang ,  Daniel J. Suich ,  Karl O. Voss

    IPC分类号： G01N33/545 ,  G01N33/543

    CPC分类号： G01N33/54366 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0668 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44726 ,  G01N27/44795 ,  G01N33/582

    摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.

    摘要翻译： 提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。 使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。 附件来自可触发事件，如光活化，热激活或化学活化。 根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。 因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。 分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。