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17 条记录 (耗时 0.019 秒)

    Ferrocenyl-1,2-diphosphines, the production thereof and their use
    1.
    发明授权
    Ferrocenyl-1,2-diphosphines, the production thereof and their use 失效
    二茂铁基-1,2-二膦，其生产及其用途

    公开(公告)号：US07375241B2

    公开(公告)日：2008-05-20

    申请号：US10582406

    申请日：2004-12-10

    申请人： Matthias Lotz ,  Martin Kesselgruber ,  Marc Thommen ,  Benoît Pugin

    发明人： Matthias Lotz ,  Martin Kesselgruber ,  Marc Thommen ,  Benoît Pugin

    IPC分类号： C07F5/02 ,  C07F15/00 ,  C07C229/00 ,  C07C69/34

    CPC分类号： C07C233/51 ,  C07B2200/07 ,  C07C67/303 ,  C07C233/48 ,  C07C2601/14 ,  C07F17/02 ,  C07C69/34

    摘要： The invention relates to compounds of formula (I) provided in the form of racemic compounds, mixtures of diastereomers or essentially pure diastereomers, wherein R1 represents a hydrogen atom or C1-C4-alkyl, and at least one secondary phosphine depicts an unsubstituted or substituted cyclic phosphine group, or phosphonium salts thereof having one or two monovalent anions or a divalent anion. The compounds of formula (I) can be obtained by means of a novel method and are valuable ligands for catalytically active metal complexes in asymmetrical synthesis

    摘要翻译： 本发明涉及以消旋化合物的形式提供的式（I）化合物，非对映异构体或基本上纯的非对映异构体的混合物，其中R 1表示氢原子或C 1〜 -C 4 - 亚烷基，至少一个仲膦表示未取代或取代的环膦基，或其具有一个或两个单价阴离子或二价阴离子的鏻盐。 式（I）化合物可以通过新的方法获得，并且是不对称合成中催化活性金属络合物的有价值的配体

    Method for producing orthometalated and orthosubstituted aromatic compounds
    2.
    发明申请
    Method for producing orthometalated and orthosubstituted aromatic compounds 失效
    用于生产正金属化和邻位取代芳族化合物的方法

    公开(公告)号：US20070149796A1

    公开(公告)日：2007-06-28

    申请号：US10582404

    申请日：2004-12-10

    申请人： Andreas Pfaltz ,  Matthias Lotz ,  Marc Schonleber ,  Benoit Pugin ,  Martin Kesselgruber ,  Marc Thommen

    发明人： Andreas Pfaltz ,  Matthias Lotz ,  Marc Schonleber ,  Benoit Pugin ,  Martin Kesselgruber ,  Marc Thommen

    IPC分类号： C07F17/02

    CPC分类号： C07F9/65848 ,  C07F17/02

    摘要： The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents —Li, —MgX3, (C1-C18-Alkyl)3Sn—, —ZnX3 or —B(O—C1C4-Alkyl)2; X1 and X2, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group —C═C—, together with C atoms, forms a hydrocarbon aromatic compound and represents X3 Cl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group —P(X1—)(X2—) - - - (BH3)0,1 can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.

    摘要翻译： 本发明涉及在芳族烃环中具有式（I）结构元件的化合物，其中：M表示-Li，-MgX 3，（C 1 -C 3） 烷基）3-Sn-，-ZnX 3或-B（OC 1 -C 4） 仲烷基）2

    Ferrocenyl-1,2-diphosphines, the production thereof and their use
    3.
    发明申请
    Ferrocenyl-1,2-diphosphines, the production thereof and their use 失效
    二茂铁基-1,2-二膦，其生产及其用途

    公开(公告)号：US20070142655A1

    公开(公告)日：2007-06-21

    申请号：US10582406

    申请日：2004-12-10

    申请人： Matthias Lotz ,  Martin Kesselgruber ,  Marc Thommen ,  Benoit Pugin

    发明人： Matthias Lotz ,  Martin Kesselgruber ,  Marc Thommen ,  Benoit Pugin

    IPC分类号： C07F17/02

    CPC分类号： C07C233/51 ,  C07B2200/07 ,  C07C67/303 ,  C07C233/48 ,  C07C2601/14 ,  C07F17/02 ,  C07C69/34

    摘要： The invention relates to compounds of formula (I) provided in the form of racemic compounds, mixtures of diastereomers or essentially pure diastereomers, wherein R1 represents a hydrogen atom or C1-C4-alkyl, and at least one secondary phosphine depicts an unsubstituted or substituted cyclic phosphine group, or phosphonium salts thereof having one or two monovalent anions or a divalent anion. The compounds of formula (I) can be obtained by means of a novel method and are valuable ligands for catalytically active metal complexes in asymmetrical synthesis.

    摘要翻译： 本发明涉及以消旋化合物的形式提供的式（I）化合物，非对映异构体或基本上纯的非对映异构体的混合物，其中R 1表示氢原子或C 1〜 -C 4 - 亚烷基，至少一个仲膦表示未取代或取代的环膦基，或其具有一个或两个单价阴离子或二价阴离子的鏻盐。 式（I）化合物可以通过新方法获得，并且是不对称合成中催化活性金属络合物的有价值的配体。

    Diphosphines and metal complexes
    4.
    发明授权
    Diphosphines and metal complexes 有权
    二膦和金属络合物

    公开(公告)号：US07863447B2

    公开(公告)日：2011-01-04

    申请号：US11887448

    申请日：2006-04-19

    申请人： Martin Kesselgruber ,  Marc Thommen ,  Matthias Lotz

    发明人： Martin Kesselgruber ,  Marc Thommen ,  Matthias Lotz

    IPC分类号： C07F15/02 ,  C07F9/02

    CPC分类号： B41K1/28 ,  B41K1/32 ,  C07F17/02

    摘要： A compound of the formula I or I′, where the radicals R1 are each, independently of one another, a hydrogen atom or C1-C4-alkyl and R′1 is C1-C4-alkyl; X1 and X2 are each, independently of one another, a sec-phosphino group; R2 is (1) hydrogen, (2) R01R02R03Si—, (3) C1-C18-acyl substituted with halogen, hydroxyl, C1-C8-alkoxy or R04R05N—, or (4) R06—X01—C(O)—; R01, R02 and R03 are each, independently of one another, C1-C12-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C6-C10-aryl or C7-C12-aralkyl; R04 and R05 are each, independently of one another, hydrogen, C1-C12-alkyl, C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl, or R04 and R05 together are trimethylene, tetramethylene, pentamethylene or 3-oxapentylene; R06 is C1-C18-alkyl, unsubstituted or C1-C4-alkyl- or C1-C4-alkoxy-substituted C3-C8-cycloalkyl, C6-C10-aryl or C7-C12-aralkyl; X01 is —O— or —NH—; T is C-bonded C3-C20-heteroarylene; v is 0 or an integer from 1 to 4; X1 in the heteroring of the heteroarylene is bound in the ortho position relative to the T—C* bond; and * indicates a mixture of racemic or enantiomerically pure diastereomers or pure racemic or enantiomerically pure diastereomers.

    摘要翻译： 式I或I'的化合物，其中基团R 1各自彼此独立地为氢原子或C 1 -C 4 - 烷基，R 11为C 1 -C 4 - 烷基; X1和X2各自独立地为仲膦基; R2是（1）氢，（2）R01R02R03Si-，（3）被卤素，羟基，C1-C8-烷氧基或R04R05N-或（4）R06-X01-C（O） - 取代的C1-C18-酰基。 R01，R02和R03各自独立地为C1-C12-烷基，未取代的或C1-C4-烷基 - 或C1-C4-烷氧基取代的C6-C10-芳基或C7-C12-芳烷基; R 04和R 05彼此独立地为氢，C 1 -C 12 - 烷基，C 3 -C 8 - 环烷基，C 6 -C 10 - 芳基或C 7 -C 12 - 芳烷基，或R 04和R 05一起是三亚甲基，四亚甲基，五亚甲基或3 - 氧亚辛 R06是C1-C18-烷基，未取代的或C1-C4-烷基 - 或C1-C4-烷氧基取代的C3-C8-环烷基，C6-C10-芳基或C7-C12-芳烷基; X01为-O-或-NH-; T是C-C 3 -C 20亚杂芳基; v为0或1至4的整数; 杂亚芳基的杂环中的X 1相对于T-C *键在邻位结合; 和*表示外消旋或对映体纯的非对映异构体或纯外消旋或对映体纯的非对映异构体的混合物。

    Method for producing orthometalated and orthosubstituted metallocenes
    5.
    发明授权
    Method for producing orthometalated and orthosubstituted metallocenes 失效
    生产原位金属和原位取代金属茂的方法

    公开(公告)号：US07435840B2

    公开(公告)日：2008-10-14

    申请号：US10582404

    申请日：2004-12-10

    申请人： Andreas Pfaltz ,  Matthias Lotz ,  Marc Schönleber ,  Benoît Pugin ,  Martin Kesselgruber ,  Marc Thommen

    发明人： Andreas Pfaltz ,  Matthias Lotz ,  Marc Schönleber ,  Benoît Pugin ,  Martin Kesselgruber ,  Marc Thommen

    IPC分类号： C07F15/00 ,  B01J31/00

    CPC分类号： C07F9/65848 ,  C07F17/02

    摘要： The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents —Li, —MgX3, (C1-C18-Alkyl)3Sn—, —ZnX3 or —B(O—C1-C4-Alkyl)2; X1 and X2, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group —C═C—, together with C atoms, forms a hydrocarbon aromatic compound and represents X3 Cl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group —P(X1—)(X2—) - - - -(BH3)0,1 can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.

    摘要翻译： 本发明涉及在芳族烃环中具有式（I）结构元件的化合物，其中：M表示-Li，-MgX 3，（C 1 -C 3） 烷基）3-Sn-，-ZnX 3或-B（OC 1 -C 3） 4 - 烷基）2 然后可以转化成次膦基。 本发明的方法甚至可以大量生产单膦和二膦，这是用作金属络合物的有价值的配体，用作催化剂。 对映选择性氢化。

    Substituted ferrocenyldiphosphines as ligands for homogeneous hyrogeneration catalysts
    6.
    发明授权
    Substituted ferrocenyldiphosphines as ligands for homogeneous hyrogeneration catalysts 有权
    取代的二茂铁基二膦作为均相杂生子催化剂的配体

    公开(公告)号：US07244860B2

    公开(公告)日：2007-07-17

    申请号：US10556085

    申请日：2004-05-07

    申请人： Felix Spindler ,  Matthias Lotz ,  Marc Thommen

    发明人： Felix Spindler ,  Matthias Lotz ,  Marc Thommen

    IPC分类号： C07C69/63

    CPC分类号： B01J31/2409 ,  B01J31/2295 ,  B01J2231/645 ,  B01J2531/0286 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07F17/02

    摘要： Compounds of the formula (I), in which R1 is C1-C4alkyl, C6-C10aryi or C7-C11, aralkyl, R2 is an open-chain or cyclic secondary amino group, and R is a radical of the formula in which R3 is C1-C4alkyl or C1-C4alkoxy, and R4 is H, C1-C4alkyl or C1-C4alkoxy, are ligands for metal complexes as homogeneous hydrogenation catalysts for prochiral organic compounds containing double bonds, by means of which a very high activity and productivity and also enantioselectivity can be achieved

    摘要翻译： 式（I）化合物，其中R 1是C 1 -C 4烷基，C 6 - -C 10芳基或C 7 -C 11芳烷基，R 2是开链或环状的 仲氨基，R是下式的基团，其中R 3是C 1 -C 4烷基或C 1 -C 4烷基， C 1 -C 4烷氧基，R 4是H，C 1 -C 4烷基或C 1 -C 4烷基或C 作为具有双键的前置手性有机化合物的均匀氢化催化剂的金属配合物的配体，通过其具有非常高的活性和生产率以及对映选择性 可以实现

    Substituted ferrocenyldiphosphines as ligands for homogeneous hyrogeneration catalysts
    7.
    发明申请
    Substituted ferrocenyldiphosphines as ligands for homogeneous hyrogeneration catalysts 有权
    取代的二茂铁基二膦作为均相杂生子催化剂的配体

    公开(公告)号：US20060241315A1

    公开(公告)日：2006-10-26

    申请号：US10556085

    申请日：2004-05-07

    申请人： Felix Spindler ,  Matthias Lotz ,  Marc Thommen

    发明人： Felix Spindler ,  Matthias Lotz ,  Marc Thommen

    IPC分类号： C07F17/02

    CPC分类号： B01J31/2409 ,  B01J31/2295 ,  B01J2231/645 ,  B01J2531/0286 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07B53/00 ,  C07F17/02

    摘要： Compounds of the formula (1), in which R1 is C1-C4alkyl, C6-C10aryi or C7-C11,aralkyl, R2 is an open-chain or cyclic secondary amino group, and R is a radical of the formula in which R3 is C1-C4alkyl or C1-C4alkoxy, and R4 is H, Cl-C4alkyl or C1-C4alkyloxy, are ligands for metal complexes as homogeneous hydrogenation catalysts for prochiral organic compounds containing double bonds, by means of which a very high activity and productivity and also enantioselectivity can be achieved.

    摘要翻译： 式（1）的化合物，其中R 1是C 1 -C 4烷基，C 6 - -C 10芳基或C 7 -C 11芳烷基，R 2是开链或环状的 仲氨基，R是下式的基团，其中R 3是C 1 -C 4烷基或C 1 -C 4烷基， C 1 -C 4烷基，R 4是H，C 1 -C 4烷基或C 1 -C 4烷基， -C 4烷基氧基是金属络合物作为含双键的前置手性有机化合物的均匀氢化催化剂的配位体，通过这些配体可以获得非常高的活性和生产率以及对映选择性。