公开(公告)号：US07601674B2

公开(公告)日：2009-10-13

申请号：US10495094

申请日：2002-11-15

申请人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

发明人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

IPC分类号： A01N37/18 ,  C07C233/00

CPC分类号： C07C235/34 ,  A01N37/18 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N43/10 ,  C07C235/78 ,  C07C323/60

摘要： The invention relates to α-oxygenated or α-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl or halocycloalkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl-alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or optionally substituted arylalkyl, optionally substituted-aryl-alkenyl, optionally substituted aryl-alkynyl or optionally substituted aryloxy-alkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl-alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or is optionally substituted aryl-alkyl, optionally substituted aryl-alkenyl, optionally substituted aryl-alkynyl, optionally substituted aryloxy-alkyl, optionally substituted heteroaryl-alkyl, optionally substituted heteroaryl-alkenyl or optionally substituted heteroaryl-alkynyl; R4 is alkyl, alkenyl, alkynyl, alkoxy-alkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkanoyl, alkylamino, dialkylamino, alkoxycarbonyl, whereof all alkyl-alkenyl or alkynyl-groups may be optionally substituted by halogen; or is halogen, cyano, nitro, amino, formyl or carboxyl; R5 is hydrogen, alkyl, alkenyl or alkynyl; n is an integer 0, 1, 2, 3, or 4; B1 represents a bridge member —(CR10R11)q— or —(CHR10R11)r-Z-(CR12R13)8, wherein q is an integer 2, 3 or 4; r is an integer 0, 1; 2, 3; s is an integer 1, 2 or 3, provided that (r+s) is either 1, 2 or 3; Z is —O—, —S—, —SO— —SO2-, NR6—, —CO—, —OOC—, —COO—, —NR6—CO— or —CO—NR6—; R6 is hydrogen or alkyl; R10, R11, R12 and R13 independently of each other are hydrogen or alkyl; and B2 is an alkylene bridge. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

公开(公告)号：US20050245607A1

公开(公告)日：2005-11-03

申请号：US10522077

申请日：2003-07-23

申请人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

发明人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

IPC分类号： C07D333/24 ,  C07C215/64 ,  C07C215/74 ,  C07C217/74 ,  C07C217/80 ,  C07C235/36 ,  C07C235/38 ,  C07C323/62 ,  C07D213/56 ,  C07D213/61 ,  C07D307/54 ,  C07D333/28 ,  C07F7/18 ,  A61K31/277 ,  A61K31/165

CPC分类号： C07C235/36 ,  C07C215/64 ,  C07C215/74 ,  C07C217/74 ,  C07C217/80 ,  C07C235/38 ,  C07C2601/14 ,  C07F7/1804

摘要： The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1-C12alkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; R2 is hydrogen; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl; R3 is optionally substituted aryl or optionally substituted heteroaryl; A is an optionally substituted saturated or unsaturated C3-C8-cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R4 and R5 are each independently hydrogen or an organic radical, and R6 is hydrogen; tri-C1-C4alkyl-silyl; di-C1-C4alkyl-phenylsilyl; C1-C4alkyl-diphenylsilyl; triphenylsilyl; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl. The compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic miroorganism, especially fungi.

摘要翻译： 本发明涉及通式（I）的N-双芳基 - 和N-芳基 - 环丙烯基-α-羟基 - 和α-烷氧基乙酰胺，其包括其旋光异构体和这些异构体的混合物，其中R 1 氢，C 1 -C 12烷基; C 2 -C 12链烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; R 2是氢; 任选取代的烷基; 任选取代的烯基或任选取代的炔基; R 3是任选取代的芳基或任选取代的杂芳基; A是任选取代的饱和或不饱和C 3 -C 8 - 亚烷基，任选取代的亚苯基或任选取代的饱和或不饱和杂环亚烷基桥，R 4 >和R 5各自独立地为氢或有机基团，并且R 6为氢; 三-C 1 -C 4烷基 - 甲硅烷基; 二-C 1 -C 4烷基 - 苯基甲硅烷基; C 1 -C 4烷基 - 二苯基甲硅烷基; 三苯基甲硅烷基; 任选取代的烷基; 任选取代的烯基或任选取代的炔基。 该化合物具有植物保护性质，适用于保护植物免受植物病原微生物特别是真菌的侵袭。

公开(公告)号：US20050014950A1

公开(公告)日：2005-01-20

申请号：US10495257

申请日：2002-11-15

申请人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

发明人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

IPC分类号： C07C231/02 ,  C07C213/02 ,  C07C231/00 ,  C07C233/00 ,  C07C235/08 ,  C07C235/32 ,  C07C235/34 ,  C07D213/56

CPC分类号： C07C233/22

摘要： The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a α-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.

摘要翻译： 本发明涉及制备式（I）的2-苯基-2-羟基-N- [2-（3-烷氧基-4-羟基苯基） - 乙基] - 乙酰胺的新方法，其中R1是烷基，R2 和R 3各自独立地为氢或烷基，R 4为任选取代的芳基或任选取代的杂芳基，该方法包括使式（II）的2-（3-烷氧基-4-羟基苯基） - 乙胺反应，其中R1R2和R3 （III）的α-羟基羧酸酯或式（III）a的二氧戊环酮，其中R 4如上所定义，R 5，R 6和R 7彼此独立地为低级烷基。 式（I）化合物是衍生自扁桃酸酰胺的新型杀真菌剂组的重要中间体。

公开(公告)号：US06538159B2

公开(公告)日：2003-03-25

申请号：US09872576

申请日：2001-06-01

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

IPC分类号： A61K3116

CPC分类号： A01N41/06 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11

摘要： The invention relates to &agr;-sulfin- and &agr;-sulfonamino acid amides of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1-C12alkyl, C1-C12alkyl substituted with C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or C3-C6alkenyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; or a group NR12R13 wherein R12 and R13 are each independently of the other hydrogen or C1-C6-alkyl, or together are tetra- or penta-methylene; R2 and R3 are each independently hydrogen; C1-C8alkyl; C1-C8alkyl substituted with hydroxy, mercapto, C1-C4alkoxy or C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; R4, R5, R6 and R7 are each independently hydrogen or C1-C4alkyl; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9, R10, R14, R15, R16 and R17 are each independently hydrogen or C1-C4alkyl; A is optionally substituted phenyl, and to the preparation of those substances and to agrochemical compositions comprising at least one of those compounds as active ingredient. The invention relates also to the preparation of the said compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及包含其光学异构体的通式I的α-亚磺酸和α-磺氨基酰胺和这些异构体的混合物，其中n是数个零或一个; R 1是C 1 -C 12烷基，被C 1 -C 12取代的C 1 -C 12烷基， C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6烯氧基羰基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; 或NR 12 R 13基团，其中R 12和R 13各自独立地为氢或C 1 -C 6 - 烷基，或一起为四或五亚甲基; R 2和R 3各自独立地为氢; C1-C8烷基; 被羟基，巯基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; R 4，R 5，R 6和R 7各自独立地为氢或C 1 -C 4烷基; R 8为C 1 -C 6烷基， C 3 -C 6烯基或C 3 -C 6炔基; R 9，R 10，R 14，R 15，R 16和R 17各自独立地为氢或C 1 -C 4烷基; A为任选取代的苯基，并且为这些物质的制备以及包含至少一种 化合物作为活性成分。 本发明还涉及所述组合物的制备以及化合物或组合物在控制或预防植物病原微生物特别是真菌侵染植物中的用途。

公开(公告)号：US06538016B2

公开(公告)日：2003-03-25

申请号：US09872577

申请日：2001-06-01

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth

IPC分类号： A61K3116

CPC分类号： C07C323/12 ,  C07C307/06 ,  C07C311/06

摘要： The invention relates to &agr;-sulfin- and &agr;-sulfonamino acid amides of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1-C12alkyl, C1-C12alkyl substituted with C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8cycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C6alkenyloxycarbonyl or C3-C6alkynyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; or a group NR12R13 wherein R12 and R13 are each independently of the other hydrogen or C1-C6-alkyl, or together are tetra- or penta-methylene; R2 and R3 are each independently hydrogen; C1-C8alkyl; C1-C8alkyl substituted with hydroxy, mercapto, C1-C4alkoxy or C1-C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8cycloalkyl-C1-C4alkyl; or the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered hydrocarbon ring; R4, R5, R6 and R7 are each independently hydrogen or C1-C4alkyl; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 and R10 are each independently hydrogen or C1-C4alkyl; and R11 is either  in wherein R14, R,15, R16 and R17 are each independently hydrogen or C1-C4alkyl, X is oxygen, sulfur or —NR18—, wherein R18 is hydrogen or C1-C4alkyl, and A is optionally substituted mono- or polycylic aryl or heteroaryl, and to the preparation of those substances and to agrochemical compositions comprising at least one of those compounds as active ingredient. The invention relates also to the preparation of compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及包含其光学异构体的通式I的α-亚磺酸和α-磺氨基酰胺和这些异构体的混合物，其中n是数个零或一个; R 1是C 1 -C 12烷基，被C 1 -C 12取代的C 1 -C 12烷基， C4烷氧基，C1-C4烷硫基，C1-C4烷基磺酰基，C3-C8环烷基，氰基，C1-C6烷氧基羰基，C3-C6烯氧基羰基或C3-C6炔氧基羰基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; 或NR 12 R 13基团，其中R 12和R 13各自独立地为氢或C 1 -C 6 - 烷基，或一起为四或五亚甲基; R 2和R 3各自独立地为氢; C1-C8烷基; 被羟基，巯基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基; C 3 -C 8环烷基-C 1 -C 4烷基; 或两个R 2和R 3与它们所键合的碳原子一起形成三至八元烃环; R 4，R 5，R 6和R 7各自独立地为氢或C 1 -C 4烷基; R 8为C 1 -C 6烷基， C 3 -C 6烯基或C 3 -C 6炔基; R 9和R 10各自独立地为氢或C 1 -C 4烷基; 并且R 11在其中R 14，R 15，R 16和R 17各自独立地为氢或C 1 -C 4烷基，X为氧，硫或-NR 18 - ，其中R 18为氢或C 1 -C 4烷基，A为任选取代的单或多环芳基 或杂芳基，以及这些物质的制备以及包含这些化合物中的至少一种作为活性成分的农药组合物。 本发明还涉及组合物的制备以及化合物或组合物在通过植物病原微生物特别是真菌控制或预防植物感染中的用途。

公开(公告)号：US06469005B1

公开(公告)日：2002-10-22

申请号：US09903651

申请日：2001-07-11

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

IPC分类号： A01N4358

CPC分类号： A01N43/40 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/50 ,  A01N43/08 ,  A01N43/10 ,  A01N43/28 ,  A01N43/30 ,  A01N43/32 ,  A01N43/54 ,  A01N47/12 ,  C07C235/34 ,  C07C235/80 ,  C07C251/40 ,  C07C271/22 ,  C07C323/62

摘要： Propargylether derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl and R9 is a group R10 is optionally substituted aryl or optionally substituted heteroaryl, R11 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl, Z is hydrogen —CO—R16, —COOR16, —CO—COOR16 or —CONR16R17, R12 is hydrogen, or optionally substituted alkyl, alkenyl or alkynyl, R13 is hydrogen or alkyl, R14 is hydrogen, alkyl, cycloalkyl or cycloalkyl-alkyl, R15 is alkyl, alkenyl, alkynyl, optionally substituted aryl or optionally substituted aryl-alkyl, and R16 and R17 are independently of each other hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.

摘要翻译： 式I的丙酰醚衍生物包括其光学异构体和这些异构体的混合物，其中R 1是氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基，烯基或炔基，R 5，R 6，R 7 ，和R 8各自独立地为氢或烷基，R 9为基团R 10为任选取代的芳基或任选取代的杂芳基，R 11为氢或任选取代的烷基，烯基或炔基，Z为氢-CO-R 16，-COOR 16，-CO-COOR 16或 -CONR 16 R 17，R 12是氢或任选取代的烷基，烯基或炔基，R 13是氢或烷基，R 14是氢，烷基，环烷基或环烷基 - 烷基，R 15是烷基，烯基，炔基，任选取代的芳基或任选取代的芳基 - 烷基，R16和R17彼此独立地为氢，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基，已被发现是有用的 用于控制或防止由植物病原微生物，特别是真菌侵染植物。本发明涉及新化合物以及其制备方法以及本发明化合物用于植物保护的用途，以及适用于农业技术中的新型化合物的组合物 。

公开(公告)号：US07521579B2

公开(公告)日：2009-04-21

申请号：US10495257

申请日：2002-11-15

申请人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

发明人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

IPC分类号： C07C233/05 ,  C07C231/02

CPC分类号： C07C233/22

摘要： The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a α-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.

摘要翻译： 本发明涉及制备式（I）的2-苯基-2-羟基-N- [2-（3-烷氧基-4-羟基苯基） - 乙基] - 乙酰胺的新方法，其中R1是烷基，R2 和R 3各自独立地为氢或烷基，R 4为任选取代的芳基或任选取代的杂芳基，该方法包括使式（II）的2-（3-烷氧基-4-羟基苯基） - 乙胺反应，其中R1R2和R3 （III）的α-羟基羧酸酯或式（III）a的二氧戊环酮，其中R 4如上所定义，R 5，R 6和R 7彼此独立地为低级烷基。 式（I）化合物是衍生自扁桃酸酰胺的新型杀真菌剂组的重要中间体。

公开(公告)号：US07189873B2

公开(公告)日：2007-03-13

申请号：US10528668

申请日：2003-10-09

申请人： Clemens Lamberth ,  Martin Zeller

发明人： Clemens Lamberth ,  Martin Zeller

IPC分类号： C07C233/05 ,  C07C311/03 ,  A01N37/18 ,  A01N41/06

CPC分类号： A01N37/38 ,  A01N41/02 ,  A01N41/06 ,  C07C243/32 ,  C07C259/06

摘要： The invention relates to 4-propargyloxy-benzyl dervatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl; R2, R3, R5, R6, and R7 are each independently of each other hydrogen or optionally substituted alkyl; R4 is optionally substituted alkyl; X is O or N—R7; and R8 is a group R9 is optionally substituted aryl or optionally substituted heteroaryl; R10 and R11 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; R12 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl; R13 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl; and R14 is optionally substituted alkyl or optionally substituted amino. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi

摘要翻译： 本发明涉及通式（I）的4-炔丙氧基 - 苄基衍生物，包括其旋光异构体和这些异构体的混合物，其中R 1是氢，任选取代的烷基，任选取代的环烷基或任选地 取代芳基; R 2，R 3，R 5，R 6和R 7， 各自独立地为氢或任选取代的烷基; R 4是任选取代的烷基; X是O或N-R 7; 并且R 8是基团R 9是任选取代的芳基或任选取代的杂芳基; R 10和R 11各自独立地为氢，任选取代的烷基，任选取代的烯基或任选取代的炔基; R 12是任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基; R 13是氢或任选取代的烷基，烯基或炔基; 并且R 14是任选取代的烷基或任选取代的氨基。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止由植物病原微生物特别是真菌侵染植物

公开(公告)号：US20060167316A1

公开(公告)日：2006-07-27

申请号：US10528668

申请日：2003-10-09

申请人： Clemens Lamberth ,  Martin Zeller

发明人： Clemens Lamberth ,  Martin Zeller

IPC分类号： C07C239/14

CPC分类号： A01N37/38 ,  A01N41/02 ,  A01N41/06 ,  C07C243/32 ,  C07C259/06

摘要： The invention relates to 4-propargyloxy-benzyl dervatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl; R2, R3, R5, R6, and R7 are each independently of each other hydrogen or optionally substituted alkyl; R4 is optionally substituted alkyl; X is O or N—R7; and R8 is a group R9 is optionally substituted aryl or optionally substituted heteroaryl; R10 and R11, are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; R12 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl; R13 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl; and R14 is optionally substituted alkyl or optionally substituted amino. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及通式（I）的4-炔丙氧基 - 苄基衍生物，包括其旋光异构体和这些异构体的混合物，其中R 1是氢，任选取代的烷基，任选取代的环烷基或任选地 取代芳基; R 2，R 3，R 5，R 6和R 7， 各自独立地为氢或任选取代的烷基; R 4是任选取代的烷基; X是O或N-R 7; 并且R 8是基团R 9是任选取代的芳基或任选取代的杂芳基; R 10和R 11各自独立地为氢，任选取代的烷基，任选取代的烯基或任选取代的炔基; R 12是任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基; R 13是氢或任选取代的烷基，烯基或炔基; 并且R 14是任选取代的烷基或任选取代的氨基。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止植物病原微生物特别是真菌侵染植物。

公开(公告)号：US20050026785A1

公开(公告)日：2005-02-03

申请号：US10495153

申请日：2002-11-15

申请人： Martin Zeller ,  Clemens Lamberth

发明人： Martin Zeller ,  Clemens Lamberth

IPC分类号： C07D239/36 ,  A01N37/18 ,  A01N37/36 ,  A61P17/00 ,  C07B53/00 ,  C07C231/12 ,  C07C235/08 ,  C07C255/16 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D215/14 ,  C07D239/26 ,  C07D241/42 ,  C07D261/08 ,  C07D277/64 ,  C07D307/54 ,  C07D307/78 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D333/28 ,  C07D333/54 ,  C07D333/60 ,  A01N25/00 ,  A01N57/18

CPC分类号： C07D239/26 ,  A01N37/36 ,  C07C2601/02 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/18 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D241/42 ,  C07D261/08 ,  C07D277/64 ,  C07D307/54 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D333/28 ,  C07D333/54 ,  C07D333/60

摘要： The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenal or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkal, R9 is hydrogen, optionally substituted alkyl, optionnaly substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionaly substituted heteroaryl, and Z is optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy or optionally substituted alkynyloxy. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及通式I的苯基炔丙基醚衍生物，其包括其旋光异构体和这些通式的混合物，其中R 1是氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基 ，烯基或炔基，R 5，R 6，R 7和R 8各自独立地为氢或碱，R 9为氢，任选取代的烷基，选择性取代的烯基或任选取代的炔基，R 10为任选取代的芳基或任选取代的杂芳基，Z为任选的 取代的芳氧基，任选取代的烷氧基，任选取代的烯氧基或任选取代的炔氧基。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止植物病原微生物特别是真菌侵染植物。