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    VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
    1.
    发明申请
    VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
    用于治疗阿尔茨海默病的疫苗

    公开(公告)号：US20110002949A1

    公开(公告)日：2011-01-06

    申请号：US12496823

    申请日：2009-07-02

    申请人： Mary J. Savage ,  Gene G. Kinney ,  Xiaoping Liang ,  Michael Citron ,  Laura B. Rosen

    发明人： Mary J. Savage ,  Gene G. Kinney ,  Xiaoping Liang ,  Michael Citron ,  Laura B. Rosen

    IPC分类号： A61K39/00 ,  G01N33/53

    CPC分类号： A61K39/0007 ,  A61K47/646 ,  A61K2039/55577 ,  A61K2039/6068 ,  A61K2039/627 ,  A61K2039/64

    摘要： The invention provides a method for the treatment of a patient having a more severe form of Alzheimer's disease (AD), where the severe form of AD is characterized by pathogenic deposits of amyloid beta peptide (Aβ), comprising the administration of an immunogenic fragment of Aβ capable of inducing an immune response in the form of antibodies to specific to the pathogenic deposits of Aβ and, in particular, to neurotoxic forms of Aβ including N-terminally truncated forms of Aβ. The invention further provides a method for selecting a suitable immunogenic fragment of Aβ for the treatment of a more severe form of AD.

    摘要翻译： 本发明提供了一种治疗患有更严重形式的阿尔茨海默病（AD）的患者的方法，其中严重形式的AD的特征在于淀粉样蛋白β肽（A＆bgr）的病原性沉积物，其包括施用免疫原性片段 的A＆BGR 能够诱导针对A＆bgr的致病性沉积物特异性的抗体形式的免疫应答; 特别是A＆BGR的神经毒性形式; 包括N末端截短形式的A＆bgr。 本发明还提供了一种选择A＆bgr的合适的免疫原性片段的方法; 用于治疗更严重的AD形式。

    Polynucleotide vaccines expressing codon optimized HIV-1 Nef and modified HIV-1 Nef
    3.
    发明申请
    Polynucleotide vaccines expressing codon optimized HIV-1 Nef and modified HIV-1 Nef 审中-公开
    表达密码子优化的HIV-1 Nef和修饰的HIV-1 Nef的多核苷酸疫苗

    公开(公告)号：US20050215508A1

    公开(公告)日：2005-09-29

    申请号：US11081244

    申请日：2005-03-16

    申请人： John Shiver ,  Xiaoping Liang ,  Tong-Ming Fu

    发明人： John Shiver ,  Xiaoping Liang ,  Tong-Ming Fu

    IPC分类号： A61K48/00 ,  C07K14/16

    CPC分类号： C07K14/005 ,  A61K2039/53 ,  C12N2740/16322

    摘要： Pharmaceutical compositions which comprise HIV Nef DNA vaccines are disclosed, along with the production and use of these DNA vaccines. The nef-based DNA vaccines of the invention are administered directly introduced into living vertebrate tissue, preferably humans, and express the HIV Nef protein or biologically relevant portions thereof, inducing a cellular immune response which specifically recognizes human immunodeficiency virus-1 (HIV-1). The DNA molecules which comprise the open reading frame of these DNA vaccines are synthetic DNA molecules encoding codon optimized HIV-1 Nef and derivatives of optimized HIV-1 Nef, including nef modifications comprising amino terminal leader peptides, removal of the amino terminal myristylation site, and/or modification of the Nef dileucine motif. These modifications may effect wild type characteristics of Nef, such as myristylation and down regulation of host CD4.

    摘要翻译： 公开了包含HIV Nef DNA疫苗的药物组合物以及这些DNA疫苗的生产和使用。 将本发明的基于nef的DNA疫苗直接施用于活的脊椎动物组织，优选人，并且表达HIV Nef蛋白或其生物相关部分，诱导特异性识别人免疫缺陷病毒-1（HIV-1 ）。 构成这些DNA疫苗的开放阅读框架的DNA分子是编码密码子优化的HIV-1 Nef和优化的HIV-1 Nef的衍生物的合成DNA分子，包括包含氨基末端前导肽的nef修饰，氨基末端的肉豆蔻酰化位点的去除， 和/或Nef二氨基酸基序的修饰。 这些修饰可能会影响Nef的野生型特征，如主要病毒的肉豆蔻酰化和下调。

    ANTI-POLLUTION ELECTROCATALYSIS COMPOSITE MEMBRANE AND MEMBRANE REACTOR
    4.
    发明申请
    ANTI-POLLUTION ELECTROCATALYSIS COMPOSITE MEMBRANE AND MEMBRANE REACTOR 有权
    抗污染电解质复合膜和膜反应器

    公开(公告)号：US20120090988A1

    公开(公告)日：2012-04-19

    申请号：US13322474

    申请日：2009-10-20

    申请人： Jianxin Li ,  Tonghua Wang ,  Jun Ma ,  Xiaoping Liang ,  Yang Yang ,  Hong Wang

    发明人： Jianxin Li ,  Tonghua Wang ,  Jun Ma ,  Xiaoping Liang ,  Yang Yang ,  Hong Wang

    IPC分类号： C25B13/04 ,  C25B15/02

    CPC分类号： C02F1/469 ,  B01D67/0048 ,  B01D69/145 ,  B01D71/021 ,  B01D71/022 ,  B01D71/024 ,  B01D71/027 ,  B01D2313/345 ,  B01D2315/08 ,  B01D2315/10 ,  B01D2325/10 ,  B01J19/2475 ,  B01J2219/00247 ,  C02F1/444 ,  C02F1/4672 ,  Y02W10/37

    摘要： The present invention relates an antifouling electrocatalytic composite membrane and a membrane reactor. The electrocatalytic composite membrane (3) consists of a substrate and a catalytic coating, wherein the substrate is selected from a conductive substrate or a nonconductive substrate coated with a conductive coating, and the substrate is a porous support having supporting, conducting and separating functions. The catalytic coating is supported or coated on the surface and in the pores of the conductive substrate or the conductive coating so as to increase the electrocatalytic activity of the substrate. The membrane reactor provides a trans-membrane pressure as the membrane separation power generated by a pump (7) and dead-end filtration or cross-flow filtration is applied, then the feed liquid permeates through the membrane from one side to the other to achieve the separation of the liquid; meanwhile, an electrocatalytic composite membrane (3) as anode and an auxiliary electrode (4) as cathode are connected to a power supply (1) separately by conducting wires (2) so that an electrolysis apparatus is formed. The electrocatalytic composite membrane (3) has a self-cleaning function and achieves the pollution-free operation during the membrane separation.

    摘要翻译： 本发明涉及一种防污电催化复合膜和膜反应器。 所述电催化复合膜（3）由基材和催化涂层组成，其中所述基材选自涂覆有导电涂层的导电基材或非导电基材，并且所述基材是具有支撑，导电和分离功能的多孔载体。 催化涂层被支撑或涂覆在导电基底或导电涂层的表面和孔中，以增加基底的电催化活性。 膜反应器提供跨膜压力作为由泵（7）产生的膜分离功率，并施加死端过滤或交叉流过滤，然后进料液体从一侧渗透到膜中以实现 分离液体; 同时，作为阳极的电催化复合膜（3）和作为阴极的辅助电极（4）分别通过导线（2）与电源（1）连接，形成电解装置。 电催化复合膜（3）具有自清洁功能，在膜分离过程中实现无污染的操作。

    Anti-pollution electrocatalysis composite membrane and membrane reactor
    8.
    发明授权
    Anti-pollution electrocatalysis composite membrane and membrane reactor 有权
    防污电解复合膜和膜反应器

    公开(公告)号：US09162905B2

    公开(公告)日：2015-10-20

    申请号：US13322474

    申请日：2009-10-20

    申请人： Jianxin Li ,  Tonghua Wang ,  Jun Ma ,  Xiaoping Liang ,  Yang Yang ,  Hong Wang

    发明人： Jianxin Li ,  Tonghua Wang ,  Jun Ma ,  Xiaoping Liang ,  Yang Yang ,  Hong Wang

    IPC分类号： C02F1/46 ,  B01D67/00 ,  B01D69/12 ,  C02F1/467 ,  C02F1/469 ,  B01D69/14 ,  B01D71/02 ,  B01J19/24 ,  C02F1/44

    CPC分类号： C02F1/469 ,  B01D67/0048 ,  B01D69/145 ,  B01D71/021 ,  B01D71/022 ,  B01D71/024 ,  B01D71/027 ,  B01D2313/345 ,  B01D2315/08 ,  B01D2315/10 ,  B01D2325/10 ,  B01J19/2475 ,  B01J2219/00247 ,  C02F1/444 ,  C02F1/4672 ,  Y02W10/37

    摘要： The present invention relates an antifouling electrocatalytic composite membrane and a membrane reactor. The electrocatalytic composite membrane (3) consists of a substrate and a catalytic coating, wherein the substrate is selected from a conductive substrate or a nonconductive substrate coated with a conductive coating, and the substrate is a porous support having supporting, conducting and separating functions. The catalytic coating is supported or coated on the surface and in the pores of the conductive substrate or the conductive coating so as to increase the electrocatalytic activity of the substrate. The membrane reactor provides a trans-membrane pressure as the membrane separation power generated by a pump (7) and dead-end filtration or cross-flow filtration is applied, then the feed liquid permeates through the membrane from one side to the other to achieve the separation of the liquid; meanwhile, an electrocatalytic composite membrane (3) as anode and an auxiliary electrode (4) as cathode are connected to a power supply (1) separately by conducting wires (2) so that an electrolysis apparatus is formed. The electrocatalytic composite membrane (3) has a self-cleaning function and achieves the pollution-free operation during the membrane separation.

    摘要翻译： 本发明涉及一种防污电催化复合膜和膜反应器。 所述电催化复合膜（3）由基材和催化涂层组成，其中所述基材选自涂覆有导电涂层的导电基材或非导电基材，并且所述基材是具有支撑，导电和分离功能的多孔载体。 催化涂层被支撑或涂覆在导电基底或导电涂层的表面和孔中，以增加基底的电催化活性。 膜反应器提供跨膜压力作为由泵（7）产生的膜分离功率，并施加死端过滤或交叉流过滤，然后进料液体从一侧渗透到膜中以实现 分离液体; 同时，作为阳极的电催化复合膜（3）和作为阴极的辅助电极（4）分别通过导线（2）与电源（1）连接，形成电解装置。 电催化复合膜（3）具有自清洁功能，在膜分离过程中实现无污染的操作。