公开(公告)号：US20090312409A1

公开(公告)日：2009-12-17

申请号：US12549102

申请日：2009-08-27

申请人： Masaaki Yasue ,  Mari Yamamoto

发明人： Masaaki Yasue ,  Mari Yamamoto

IPC分类号： A61K31/352 ,  A61P3/06

CPC分类号： A61K36/82 ,  A23F3/18 ,  A23L33/105 ,  A23V2002/00 ,  C07D311/62 ,  A23V2200/332 ,  A23V2200/326 ,  A23V2250/214

摘要： A lipopexia inhibitor which inhibits fat accumulation, comprising an effective amount of any methylated catechin having the following chemical formula (1) obtained by extraction of green tea or Pouchung tea, in which each of R1, R2, R3 and R4 independently is a hydrogen atom or methyl; and each of X1 and X2 independently is a hydrogen atom or hydroxyl.

摘要翻译： 抑制脂肪蓄积的脂质体抑制剂，其包含有效量的通过提取绿茶或Pouchung茶获得的具有以下化学式（1）的任何甲基化儿茶素，其中R1，R2，R3和R4各自独立地为氢原子 或甲基; X1和X2各自独立地为氢原子或羟基。

公开(公告)号：US20080319052A1

公开(公告)日：2008-12-25

申请号：US11911711

申请日：2006-04-13

申请人： Masaaki Yasue ,  Mari Yamamoto

发明人： Masaaki Yasue ,  Mari Yamamoto

IPC分类号： A61K31/352 ,  C07D311/02 ,  A61P3/04

CPC分类号： A61K36/82 ,  A23F3/18 ,  A23L33/105 ,  A23V2002/00 ,  C07D311/62 ,  A23V2200/332 ,  A23V2200/326 ,  A23V2250/214

摘要： [Problems] To provide a lipopexia inhibitor being effective for the inhibition of fat accumulation.[Means for Solving Problems] There is provided a lipopexia inhibitor comprising an effective amount of any of methylated catechins of the following chemical formula (1) obtained by extraction of green tea or Pouchung tea. (1) wherein each of R1, R2, R3 and R4 independently is a hydrogen atom or methyl; and each of X1 and X2 independently is a hydrogen atom or hydroxyl.

摘要翻译： [问题]提供对抑制脂肪蓄积有效的脂质代谢抑制剂。 [解决问题的方法]提供一种脂质体抑制剂，其含有有效量的通过提取绿茶或Pouchung茶获得的以下化学式（1）的甲基化儿茶素类。 （1）其中R1，R2，R3和R4各自独立地为氢原子或甲基; X1和X2各自独立地为氢原子或羟基。

公开(公告)号：US20070128299A1

公开(公告)日：2007-06-07

申请号：US10588428

申请日：2005-02-04

申请人： Hiroshi Nagai ,  Masaaki Yasue ,  Mari Yamamoto

发明人： Hiroshi Nagai ,  Masaaki Yasue ,  Mari Yamamoto

IPC分类号： A61K36/82 ,  A61K31/353

CPC分类号： A23F3/163 ,  A23F3/16 ,  A23L2/52 ,  A23L33/11 ,  A23L33/30 ,  A61K8/498 ,  A61K9/0095 ,  A61K31/353 ,  A61Q1/02 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/10 ,  C07D311/62

摘要： Functional beverages and compositions are provided that suppress allergic rhinitis and prevent and treat hyperlipemia and related diseases thereof i.e. arteriosclerosis, obesity and liver diseases. The O-methylated catechin expressed by the chemical formula (1) shown below is included in a constitutive effective amount as an allergic rhinitis-suppressing drug and a lipid-lowering drug; [in which R1, R2, R3 and R4 are each independently a hydrogen atom or a methyl group, X1 and X2 are each independently a hydrogen atom or a hydroxy group.]

摘要翻译： 提供功能饮料和组合物，其抑制过敏性鼻炎并预防和治疗高脂血症及其相关疾病，即动脉硬化，肥胖症和肝脏疾病。 由下述化学式（1）表示的O-甲基化儿茶素作为过敏性鼻炎抑制药和降脂药含有组成有效量; [其中R 1，R 2，R 3和R 4各自独立地为氢原子或甲基，X 1和X 2各自独立地为氢原子或羟基。

公开(公告)号：US09012482B2

公开(公告)日：2015-04-21

申请号：US13287375

申请日：2011-11-02

申请人： Yukihiko Aikawa ,  Kimiko Morimoto ,  Mari Yamamoto ,  Shunichi Shiozawa

发明人： Yukihiko Aikawa ,  Kimiko Morimoto ,  Mari Yamamoto ,  Shunichi Shiozawa

IPC分类号： A61K31/423 ,  A61P19/10 ,  C07D261/20

CPC分类号： C07D261/20 ,  A61K31/423

摘要： Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: wherein the each substituent is as defined in the specification, or salts thereof have suppressive effect on RANKL production, suppressive effect on OPG reduction and inhibitory effects on differentiation/activation of osteoclasts, and are extremely useful for treating, for example therapy and/or prevention, of various diseases in which differentiation/activation of osteoclast are involved, such as osteoporosis.

摘要翻译： 其特征在于含有以下通式表示的二苯甲酮衍生物：其中各取代基如说明书中所定义，或其盐对RANKL产生具有抑制作用，对OPG降低的抑制作用以及对破骨细胞分化/活化的抑制作用，以及 对于治疗和/或预防涉及破骨细胞分化/活化的各种疾病如骨质疏松症是非常有用的。

公开(公告)号：US08784702B2

公开(公告)日：2014-07-22

申请号：US13058681

申请日：2009-08-06

申请人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

发明人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

IPC分类号： H01B1/02 ,  H01B1/12

CPC分类号： B22F1/0062 ,  B22F1/0018 ,  B22F9/18 ,  B22F9/30 ,  B22F2999/00 ,  B82Y30/00 ,  C01G3/02 ,  C01P2002/72 ,  C01P2002/88 ,  C01P2004/04 ,  C01P2004/51 ,  C01P2004/64 ,  C07F1/005 ,  C09C1/622 ,  Y10T428/12181 ,  Y10T428/2991 ,  B22F2201/02

摘要： Copper-containing nanoparticles with excellent oxidation resistance is provided. The present invention relates to a method for manufacturing copper-containing nanoparticles including obtaining copper-containing nanoparticles that contain an organic component by heat treating an organic copper compound at a temperature equal to or higher than a decomposition initiation temperature of the compound and lower than a complete decomposition temperature of the compound in a non-oxidative atmosphere in the presence of an organic material containing a 1,2-alkanediol having 5 or more carbon atoms and/or a derivative thereof.

摘要翻译： 提供了具有优异抗氧化性的含铜纳米粒子。 本发明涉及一种制造含铜纳米粒子的方法，其包括通过在等于或高于化合物的分解引发温度的温度下热处理有机铜化合物而获得含有有机成分的含铜纳米粒子，并低于 在含有具有5个或更多个碳原子的1,2-链烷二醇和/或其衍生物的有机材料存在下，在非氧化性气氛中化合物的完全分解温度。

公开(公告)号：US20110193034A1

公开(公告)日：2011-08-11

申请号：US13058681

申请日：2009-08-06

申请人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

发明人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

IPC分类号： H01B1/22 ,  B82Y30/00

CPC分类号： B22F1/0062 ,  B22F1/0018 ,  B22F9/18 ,  B22F9/30 ,  B22F2999/00 ,  B82Y30/00 ,  C01G3/02 ,  C01P2002/72 ,  C01P2002/88 ,  C01P2004/04 ,  C01P2004/51 ,  C01P2004/64 ,  C07F1/005 ,  C09C1/622 ,  Y10T428/12181 ,  Y10T428/2991 ,  B22F2201/02

摘要： Copper-containing nanoparticles with excellent oxidation resistance is provided. The present invention relates to a method for manufacturing copper-containing nanoparticles including obtaining copper-containing nanoparticles that contain an organic component by heat treating an organic copper compound at a temperature equal to or higher than a decomposition initiation temperature of the compound and lower than a complete decomposition temperature of the compound in a non-oxidative atmosphere in the presence of an organic material containing a 1,2-alkanediol having 5 or more carbon atoms and/or a derivative thereof.

摘要翻译： 提供了具有优异抗氧化性的含铜纳米粒子。 本发明涉及一种制造含铜纳米粒子的方法，其包括通过在等于或高于化合物的分解引发温度的温度下热处理有机铜化合物而获得含有有机成分的含铜纳米粒子，并低于 在含有具有5个或更多个碳原子的1,2-链烷二醇和/或其衍生物的有机材料存在下，在非氧化性气氛中化合物的完全分解温度。

公开(公告)号：US09414487B2

公开(公告)日：2016-08-09

申请号：US14005618

申请日：2012-03-06

申请人： Nobutaka Fujimoto ,  Tomoki Kawakita ,  Ryou Miyabara ,  Masami Nakamoto ,  Toshinobu Ohno ,  Mari Yamamoto ,  Yukiyasu Kashiwagi

发明人： Nobutaka Fujimoto ,  Tomoki Kawakita ,  Ryou Miyabara ,  Masami Nakamoto ,  Toshinobu Ohno ,  Mari Yamamoto ,  Yukiyasu Kashiwagi

IPC分类号： H01B1/22 ,  C08K5/109 ,  H05K1/09 ,  C08K5/3415 ,  C08K3/08

CPC分类号： H05K1/092 ,  C08K3/08 ,  C08K5/109 ,  C08K5/3415 ,  H01B1/22 ,  H05K1/095

摘要： The present invention provides a metal paste composition which can obtain the calcined bodies having low volume resistivity in a wiring substrate after calcining. More specifically, the present invention provides a metal paste composition comprising a metal, an aliphatic polycarbonate, and an organic solvent.

摘要翻译： 本发明提供一种金属糊剂组合物，其可以在煅烧后得到在布线基板中具有低体积电阻率的煅烧体。 更具体地，本发明提供了包含金属，脂族聚碳酸酯和有机溶剂的金属膏组合物。

公开(公告)号：US08809371B2

公开(公告)日：2014-08-19

申请号：US13730000

申请日：2012-12-28

申请人： Hideyasu Fujiwara ,  Kimihiko Sato ,  Shinsuke Mizumoto ,  Yuichiro Sato ,  Hideki Kurihara ,  Yohei Kubo ,  Hiyoku Nakata ,  Yasutaka Baba ,  Takashi Tamura ,  Hidenobu Kuniyoshi ,  Shinji Hagiwara ,  Mari Yamamoto

发明人： Hideyasu Fujiwara ,  Kimihiko Sato ,  Shinsuke Mizumoto ,  Yuichiro Sato ,  Hideki Kurihara ,  Yohei Kubo ,  Hiyoku Nakata ,  Yasutaka Baba ,  Takashi Tamura ,  Hidenobu Kuniyoshi ,  Shinji Hagiwara ,  Mari Yamamoto

IPC分类号： C07D213/82

摘要： An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents a C1-12 alkyl group, a C2-12 alkenyl group, a C2-12 alkynyl group, a C3-8 cycloalkyl group, an aryl group, an ar-C1-6 alkyl group or a heterocyclic group, each optionally having at least one substituent; R3 represents an aryl group or a heterocyclic group each optionally having at least one substituent; and R4 and R5 each independently represent a hydrogen atom; and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

公开(公告)号：US20110193033A1

公开(公告)日：2011-08-11

申请号：US13058674

申请日：2009-08-06

申请人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

发明人： Masami Nakamoto ,  Mari Yamamoto ,  Yukiyasu Kashiwagi ,  Yukio Yoshida ,  Hiroshi Kakiuchi ,  Shinsuke Matsumura

IPC分类号： H01B1/12 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： B22F1/0018 ,  B22F9/18 ,  B22F9/30 ,  B82Y30/00 ,  C22C1/0425 ,  C22C1/0466 ,  Y10S977/773 ,  Y10S977/896 ,  Y10T428/2991

摘要： Metal nanoparticles having improved migration resistance are provided. The present invention relates to a method for manufacturing composite nanoparticles including obtaining composite nanoparticles containing at least silver and copper in a single particle by heat treating a mixture containing an organic silver compound and an organic copper compound at a temperature of 150° C. or more in a non-oxidative atmosphere in the presence of a tertiary amine compound represented by the general formula R1R2R3N (wherein R1 through R3 are optionally substituted alkyl groups or aryl groups that may be the same or different, R1 through R3 may be linked in a ring, and the number of carbon atoms in each of R1 through R3 is 5 through 18 and may be the same or different).

摘要翻译： 提供了具有改善的耐迁移性的金属纳米粒子。 本发明涉及一种制造复合纳米粒子的方法，其包括通过在150℃以上的温度下热处理含有机银化合物和有机铜化合物的混合物，获得单粒子中至少含有银和铜的复合纳米粒子 在由通式R 1 R 2 R 3 N表示的叔胺化合物（其中R 1至R 3是任选取代的烷基或可以相同或不同的芳基）存在下的非氧化性气氛中，R 1至R 3可以连接在环中 ，R 1〜R 3各自的碳原子数为5〜18，可以相同也可以不同。

公开(公告)号：US06899893B2

公开(公告)日：2005-05-31

申请号：US10417254

申请日：2003-04-17

申请人： Kenkou Tsuji ,  Mari Yamamoto ,  Keiko Kawamoto ,  Hirofumi Tachibana

发明人： Kenkou Tsuji ,  Mari Yamamoto ,  Keiko Kawamoto ,  Hirofumi Tachibana

IPC分类号： A23G3/34 ,  A23G4/00 ,  A23L1/30 ,  A61K8/00 ,  A61K8/60 ,  A61K8/97 ,  A61K9/00 ,  A61K31/05 ,  A61K31/7024 ,  A61K31/7032 ,  A61P29/00 ,  A61P37/08 ,  A61Q19/10 ,  C07H13/08 ,  C12N15/09 ,  A61K47/00

CPC分类号： A61K31/05 ,  A61K8/60 ,  A61K8/97 ,  A61K9/0056 ,  A61Q19/10 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/847 ,  Y10S514/848

摘要： This invention is to provide an agent for therapy and prevention of allergic diseases which has no adverse action, shows a high safety even by administration for a long period and is able to be utilized to food and/or beverage, cosmetics, etc. which are used daily. To be specific, it provides antiallergic agent and anti-inflammatory agent characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient; a method for the addition of an antiallergic agent for oral administration or an anti-inflammatory agent for oral administration which is characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient to food and/or beverage for prevention, suppression and mitigation of allergic symptoms or inflammatory symptoms.

摘要翻译： 本发明提供一种治疗和预防过敏性疾病的药剂，其不会产生不良反应，即使长时间施用也能显示高安全性，并且能够用于食品和/或饮料，化妆品等 每天使用 具体而言，提供抗变应性剂和抗炎剂，其特征在于含有至少一种选自严格菌素及其甲基化衍生物的多酚作为有效成分; 用于口服给药的抗过敏剂或口服抗炎剂的添加方法，其特征在于，含有至少一种选自其严格抑制素和甲基化衍生物的多酚作为有效成分用于预防食品和/或饮料， 抑制和缓解过敏症状或炎症症状。