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    Catalyst for cross-coupling reaction comprising unsubstituted or substituted bisphosphinobenzenes
    1.
    发明授权
    Catalyst for cross-coupling reaction comprising unsubstituted or substituted bisphosphinobenzenes 有权
    包含未取代或取代的双膦基苯的交叉偶联反应的催化剂

    公开(公告)号：US08637710B2

    公开(公告)日：2014-01-28

    申请号：US12737288

    申请日：2009-03-10

    申请人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

    发明人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

    IPC分类号： G07F9/02

    CPC分类号： C07F9/650994 ,  B01J31/2419 ,  B01J2231/4233 ,  B01J2531/842 ,  C07B37/04 ,  C07C1/325 ,  C07C1/327 ,  C07F9/5027 ,  C07F15/025

    摘要： The present invention provides a process for efficiently producing an alkylated aromatic compound in good yield, by a cross-coupling reaction between an alkyl halide and an aromatic magnesium reagent. A process for producing an aromatic compound represented by Formula (1): R—Ar′  (1) wherein R is a hydrocarbon group, and Ar′ is an aryl group; the process comprising: reacting a compound represented by Formula (2): R—X  (2) wherein X is a halogen atom, and R is as defined above, with a magnesium reagent represented by Formula (3): Ar′—MgY  (3) wherein Y is a halogen atom, and Ar′ is as defined above, in the presence of a catalyst for cross-coupling reactions comprising an iron compound and a bisphosphine compound represented by Formula (4): wherein Q is a divalent group derived from an aromatic ring by removing two hydrogen (H) atoms on adjacent carbon atoms; and each Ar is independently an aryl group.

    摘要翻译： 本发明提供了通过烷基卤和芳族镁试剂之间的交叉偶联反应，以高产率有效地制备烷基化芳族化合物的方法。 一种由式（1）表示的芳族化合物的制备方法：R-Ar'（1）其中R是烃基，Ar'是芳基; 该方法包括：使由式（2）表示的化合物：其中X是卤素原子的RX（2）和R如上所定义，与式（3）表示的镁试剂反应：Ar'-MgY（3） 其中Y是卤原子，Ar'如上定义，在含有铁化合物和由式（4）表示的双膦化合物的交叉偶联反应催化剂存在下，其中Q是衍生自 通过除去相邻碳原子上的两个氢原子; 并且每个Ar独立地为芳基。

    CATALYST FOR CROSS-COUPLING REACTION, AND PROCESS FOR PRODUCTION OF AROMATIC COMPOUND USING THE SAME
    2.
    发明申请
    CATALYST FOR CROSS-COUPLING REACTION, AND PROCESS FOR PRODUCTION OF AROMATIC COMPOUND USING THE SAME 有权
    用于交联反应的催化剂和使用它们的芳族化合物的生产方法

    公开(公告)号：US20110152523A1

    公开(公告)日：2011-06-23

    申请号：US12737288

    申请日：2009-03-10

    申请人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

    发明人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

    IPC分类号： C07F9/6509 ,  B01J31/30 ,  C07F9/50 ,  C07C1/20

    CPC分类号： C07F9/650994 ,  B01J31/2419 ,  B01J2231/4233 ,  B01J2531/842 ,  C07B37/04 ,  C07C1/325 ,  C07C1/327 ,  C07F9/5027 ,  C07F15/025

    摘要： The present invention provides a process for efficiently producing an alkylated aromatic compound in good yield, by a cross-coupling reaction between an alkyl halide and an aromatic magnesium reagent. A process for producing an aromatic compound represented by Formula (1): R—Ar′  (1) wherein R is a hydrocarbon group, and Ar′ is an aryl group; the process comprising: reacting a compound represented by Formula (2): R—X  (2) wherein X is a halogen atom, and R is as defined above, with a magnesium reagent represented by Formula (3): Ar′—MgY  (3) wherein Y is a halogen atom, and Ar′ is as defined above, in the presence of a catalyst for cross-coupling reactions comprising an iron compound and a bisphosphine compound represented by Formula (4): wherein Q is a divalent group derived from an aromatic ring by removing two hydrogen (H) atoms on adjacent carbon atoms; and each Ar is independently an aryl group.

    摘要翻译： 本发明提供了通过烷基卤和芳族镁试剂之间的交叉偶联反应，以高产率有效地制备烷基化芳族化合物的方法。 一种由式（1）表示的芳族化合物的制备方法：R-Ar'（1）其中R是烃基，Ar'是芳基; 该方法包括：使由式（2）表示的化合物：其中X是卤素原子的R-X（2）和R如上所定义，与式（3）表示的镁试剂反应：Ar'-MgY（ 3）其中Y是卤素原子，Ar'如上定义，在含有铁化合物和由式（4）表示的双膦化合物的交叉偶联反应催化剂存在下，其中Q是二价基团衍生物 通过在相邻碳原子上除去两个氢（H）原子而从芳香环; 并且每个Ar独立地为芳基。