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    Process for producing optically active amino alcohols and intermediates therefore
    4.
    发明授权
    Process for producing optically active amino alcohols and intermediates therefore 失效
    因此制造光学活性氨基醇和中间体的方法

    公开(公告)号：US06686505B2

    公开(公告)日：2004-02-03

    申请号：US10285164

    申请日：2002-10-31

    申请人： Masahito Watanabe ,  Kunihiko Murata ,  Takao Ikariya

    发明人： Masahito Watanabe ,  Kunihiko Murata ,  Takao Ikariya

    IPC分类号： C07C21302

    CPC分类号： C07C253/30 ,  C07B2200/07 ,  C07C201/12 ,  C07C213/02 ,  C07D333/24 ,  C07C215/30 ,  C07C255/36 ,  C07C205/16 ,  C07C205/26

    摘要： A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.

    摘要翻译： 提供了一种制备光学活性氨基醇的方法，其包括在具有光学活性的氮原子的过渡金属化合物催化剂存在下，使硝基酮或氰基酮与供氢有机或无机化合物反应的步骤， 含有化合物作为不对称配体，得到光学活性硝基醇或光学活性氰基醇，以及进一步还原上述光学活性醇以有效制备光学活性氨基醇的步骤。

    Ruthenium complexes and process for preparing alcoholic compounds using these
    6.
    发明授权
    Ruthenium complexes and process for preparing alcoholic compounds using these 有权
    钌络合物及其制备方法

    公开(公告)号：US06790973B2

    公开(公告)日：2004-09-14

    申请号：US10330501

    申请日：2002-12-27

    申请人： Kunihiko Tsutsumi ,  Kunihiko Murata ,  Takeshi Ota ,  Takao Ikariya

    发明人： Kunihiko Tsutsumi ,  Kunihiko Murata ,  Takeshi Ota ,  Takao Ikariya

    IPC分类号： C07F1500

    CPC分类号： C07F15/0053

    摘要： The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand. In a preferred embodiment, the invention provides an optically active ruthenium complex represented by the general formula (1) wherein X and Y, which can be identical to or different from each other, represent a hydrogen atom or an anion group, R1 and R2, which can be identical to or different from each other, represent a chain or cyclic hydrocarbon group of carbon number 1 to 20, which can be substituted, R3 and R4, which can be identical to or different from each other, represent a hydrogen atom or a hydrocarbon group of carbon number 1 to 3, and R5, R6, R7 and R8, which can be identical to or different from one another, represent a hydrocarbon group of carbon number 1 to 30, which can be substituted, with the proviso that when X and Y are bromine, R1 and R2 are a methyl group, and when R3 and R4 are a hydrogen atom, at least one of R5, R6, R7 and R8 is not a phenyl group.

    摘要翻译： 本发明提供具有光学活性二膦化合物的新型钌络合物，其具有碳不对称性并易于合成，作为配体，以及使用所述络合物作为催化剂制备光学活性醇化合物的方法，其中所述方法是 制备光学活性醇类化合物，与具有轴向手性或碳不对称性的光学活性二膦化合物作为配体的常规钌络合物催化剂相比，在羰基化合物的不对称氢化方面具有优异的反应性，选择性等优异性。 在优选的实施方案中，本发明提供由通式（1）表示的光学活性钌络合物，其中X和Y彼此相同或不同，表示氢原子或阴离子基团，R 1， 和R 2可以相同或不同，表示链或环 可以被取代的碳数1〜20的可以相同或不同的碳原子数为1〜20的烃基表示碳原子数1〜3的氢原子或烃基 ，R 5，R 6，R 7和R 8可以相同或不同，表示可以被取代的碳原子数为1〜30的烃基， 条件是当X和Y为溴时，R 1和R 2为甲基，当R 3和R 4为氢原子时，R 5，R <6>，R 7和R 8不是苯基。

    NOVEL ORGANIC METAL COMPLEX AND PROCESS FOR PREPARING AMINE COMPOUND
    8.
    发明申请
    NOVEL ORGANIC METAL COMPLEX AND PROCESS FOR PREPARING AMINE COMPOUND 有权
    新的有机金属复合物和制备胺化合物的方法

    公开(公告)号：US20100234596A1

    公开(公告)日：2010-09-16

    申请号：US12722819

    申请日：2010-03-12

    申请人： Masahito Watanabe ,  Junichi Hori ,  Kunihiko Murata

    发明人： Masahito Watanabe ,  Junichi Hori ,  Kunihiko Murata

    IPC分类号： C07C209/28 ,  C07F15/00 ,  C07C253/30 ,  C07C227/18

    CPC分类号： B01J31/2295 ,  C07C209/78 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/008

    摘要： [Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups.[Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.

    摘要翻译： 本发明的目的在于提供一种新的有机金属化合物，其可以用作对官能团具有优异选择性的通用高活性催化剂。 解决问题的手段本发明涉及具有通式（1）的新特异性结构的有机金属化合物：和用于还原胺化反应中的一般用途的高活性催化剂，对包含所述有机金属的官能团具有优异的选择性 化合物，以及通过使用所述催化剂的还原胺化反应制备胺化合物的方法。