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    Process for producing optically active amino alcohols and intermediates therefore
    4.
    发明授权
    Process for producing optically active amino alcohols and intermediates therefore 失效
    因此制造光学活性氨基醇和中间体的方法

    公开(公告)号：US06686505B2

    公开(公告)日：2004-02-03

    申请号：US10285164

    申请日：2002-10-31

    申请人： Masahito Watanabe ,  Kunihiko Murata ,  Takao Ikariya

    发明人： Masahito Watanabe ,  Kunihiko Murata ,  Takao Ikariya

    IPC分类号： C07C21302

    CPC分类号： C07C253/30 ,  C07B2200/07 ,  C07C201/12 ,  C07C213/02 ,  C07D333/24 ,  C07C215/30 ,  C07C255/36 ,  C07C205/16 ,  C07C205/26

    摘要： A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.

    摘要翻译： 提供了一种制备光学活性氨基醇的方法，其包括在具有光学活性的氮原子的过渡金属化合物催化剂存在下，使硝基酮或氰基酮与供氢有机或无机化合物反应的步骤， 含有化合物作为不对称配体，得到光学活性硝基醇或光学活性氰基醇，以及进一步还原上述光学活性醇以有效制备光学活性氨基醇的步骤。

    Ruthenium complexes and process for preparing alcoholic compounds using these
    6.
    发明授权
    Ruthenium complexes and process for preparing alcoholic compounds using these 有权
    钌络合物及其制备方法

    公开(公告)号：US06790973B2

    公开(公告)日：2004-09-14

    申请号：US10330501

    申请日：2002-12-27

    申请人： Kunihiko Tsutsumi ,  Kunihiko Murata ,  Takeshi Ota ,  Takao Ikariya

    发明人： Kunihiko Tsutsumi ,  Kunihiko Murata ,  Takeshi Ota ,  Takao Ikariya

    IPC分类号： C07F1500

    CPC分类号： C07F15/0053

    摘要： The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand. In a preferred embodiment, the invention provides an optically active ruthenium complex represented by the general formula (1) wherein X and Y, which can be identical to or different from each other, represent a hydrogen atom or an anion group, R1 and R2, which can be identical to or different from each other, represent a chain or cyclic hydrocarbon group of carbon number 1 to 20, which can be substituted, R3 and R4, which can be identical to or different from each other, represent a hydrogen atom or a hydrocarbon group of carbon number 1 to 3, and R5, R6, R7 and R8, which can be identical to or different from one another, represent a hydrocarbon group of carbon number 1 to 30, which can be substituted, with the proviso that when X and Y are bromine, R1 and R2 are a methyl group, and when R3 and R4 are a hydrogen atom, at least one of R5, R6, R7 and R8 is not a phenyl group.

    摘要翻译： 本发明提供具有光学活性二膦化合物的新型钌络合物，其具有碳不对称性并易于合成，作为配体，以及使用所述络合物作为催化剂制备光学活性醇化合物的方法，其中所述方法是 制备光学活性醇类化合物，与具有轴向手性或碳不对称性的光学活性二膦化合物作为配体的常规钌络合物催化剂相比，在羰基化合物的不对称氢化方面具有优异的反应性，选择性等优异性。 在优选的实施方案中，本发明提供由通式（1）表示的光学活性钌络合物，其中X和Y彼此相同或不同，表示氢原子或阴离子基团，R 1， 和R 2可以相同或不同，表示链或环 可以被取代的碳数1〜20的可以相同或不同的碳原子数为1〜20的烃基表示碳原子数1〜3的氢原子或烃基 ，R 5，R 6，R 7和R 8可以相同或不同，表示可以被取代的碳原子数为1〜30的烃基， 条件是当X和Y为溴时，R 1和R 2为甲基，当R 3和R 4为氢原子时，R 5，R <6>，R 7和R 8不是苯基。

    Practical Method for Reducing Esters or Lactones
    7.
    发明申请
    Practical Method for Reducing Esters or Lactones 有权
    降低酯或内酯的实用方法

    公开(公告)号：US20110092747A1

    公开(公告)日：2011-04-21

    申请号：US12991073

    申请日：2009-06-26

    申请人： Takao Ikariya ,  Masato Ito ,  Akira Shiibashi ,  Takashi Ootsuka

    发明人： Takao Ikariya ,  Masato Ito ,  Akira Shiibashi ,  Takashi Ootsuka

    IPC分类号： C07C29/149

    CPC分类号： C07C29/149 ,  C07B31/00 ,  C07B2200/07 ,  C07C31/38 ,  C07C33/22 ,  C07C33/26 ,  C07C31/20

    摘要： Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.

    摘要翻译： 在第8（VIII）族过渡金属络合物，碱和氢气（H2）的存在下，酯和内酯可以分别还原为醇和二醇。 可以通过组8（VIII）过渡金属络合物，碱，碱的使用量，氢气的压力和反应温度的优选组合来提供非常实用的还原方法。 该方法用于代替氢化物还原，并且是可以相对容易地制备高活性催化剂的设计的有用方法，同时可以预期高生产率。