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公开(公告)号:US5808144A
公开(公告)日:1998-09-15
申请号:US875284
申请日:1997-07-23
申请人: Masaichi Hasegawa , Takumi Takeyasu , Naoki Tsuchiya , Naoki Hase , Katsushi Takahashi , Takashi Kamimura
发明人: Masaichi Hasegawa , Takumi Takeyasu , Naoki Tsuchiya , Naoki Hase , Katsushi Takahashi , Takashi Kamimura
IPC分类号: C07C235/38 , C07C229/00 , C07C321/00
CPC分类号: C07C235/38 , C07C2101/14
摘要: Novel benzene derivatives of the formula (I) shown below, pharmacological salts thereof, pharmacological solvates of the above-mentioned benzene derivatives and salts, pharmaceutical compositions including, as active ingredients, the above-mentioned compounds, and especially, prophylactic or therapeutic medicines for allergic diseases. ##STR1## wherein R.sup.1 =H, C.sub.1 -C.sub.12 cyclic or straight or branched chain alkyl group (which may be substituted by one or more C.sub.6 -C.sub.10 aryloxy groups), C.sub.7 -C.sub.12 aralkyl group (of which the aryl group may be substituted one or more of halogen, methyl and methoxy, or C.sub.3 -C.sub.10 alkenyl which may be substituted by one or more phenyl groups; A=O, S or CH.sub.2 group, B=CO or CZ.sub.2 CO group (Z=H or F), R.sup.2 =H or C.sub.1 -C.sub.4 alkyl group, X=halogen or methyl group, and Y=H, NO.sub.2 or CN group.
摘要翻译: PCT No.PCT / JP96 / 03456 Sec。 371日期1997年7月23日 102(e)日期1997年7月23日PCT提交1995年11月27日PCT公布。 第WO97 / 19910号公报 日期:1997年5月6日下述式(I)的新型苯衍生物,其药理学盐,上述苯衍生物和盐的药理学溶剂化物,作为活性成分的上述化合物,特别是预防性 或用于过敏性疾病的治疗药物。 (I)其中R1 = H,C1-C12环状或直链或支链烷基(其可被一个或多个C 6 -C 10芳氧基取代),C 7 -C 12芳烷基(其芳基可以 取代一个或多个卤素,甲基和甲氧基,或可被一个或多个苯基取代的C 3 -C 10链烯基; A = O,S或CH 2基团,B = CO或CZ 2 CO基团(Z = H或F) ,R2 = H或C1-C4烷基,X =卤素或甲基,Y = H,NO2或CN基团。
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公开(公告)号:US5945450A
公开(公告)日:1999-08-31
申请号:US737991
申请日:1996-11-22
申请人: Kazuya Takenouchi , Katsushi Takahashi , Masaichi Hasegawa , Takahiro Takeuchi , Keiji Komoriya
发明人: Kazuya Takenouchi , Katsushi Takahashi , Masaichi Hasegawa , Takahiro Takeuchi , Keiji Komoriya
IPC分类号: C07C233/11 , C07C233/22 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/81 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/20 , C07C237/44 , C07C255/60 , C07C311/46 , C07C323/29 , C07C323/60 , C07C323/62 , C07D257/04 , A61K31/24 , C07C229/00
CPC分类号: C07D257/04 , C07C233/11 , C07C233/22 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/81 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/20 , C07C237/44 , C07C255/60 , C07C311/46 , C07C323/29 , C07C323/60 , C07C323/62
摘要: Naphthalene derivatives represented by formula �I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C.sub.7 -C.sub.11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C.sub.1 -C.sub.12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the allyl may be substituted with a C.sub.6 -C.sub.10 allyloxy group; Q represents O, S, CH.sub.2, O--CH.sub.2, S--CH.sub.2, CO, or CHOR.sup.1 ; L represents CO, CR.sup.2 R.sup.3 CO, CH.sub.2 CH.sub.2 CO, or CH.dbd.CHCO; D represents a hydrogen atom, NO.sub.2, NH.sub.2, CO.sub.2 R.sup.4, or a group having the following formula �II!: ##STR2## (wherein G represents. a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.6, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.5, CN, or a tetrazol-5-yl group; M represents a hydrogen atom, a C.sub.1 -C.sub.4 lower alkyl group, a nitro group, or a halogen atom; and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently each other, a hydrogen atom or a C.sub.1 -C.sub.4 lower alkyl group);pharmacologically acceptable salts thereof, or pharmacologically acceptable solvates thereof, which have, for example, an inhibitory effect on the production of IgE antibodies, and will be useful for prophylaxis and/or treatment of allergic diseases.
摘要翻译: PCT No.PCT / JP95 / 01035 Sec。 371日期:1996年11月22日 102(e)日期1996年11月22日PCT提交1995年5月30日PCT公布。 第WO95 / 32943号公报 日期:1995年12月7日由式[I]表示的萘衍生物:其中A为氢原子,羟基,C7-C11芳烷氧基或由氧基和C1-C12脂族或脂环族 饱和或不饱和的烃基,其中烯丙基可以被C 6 -C 10烯丙氧基取代; Q代表O,S,CH2,O-CH2,S-CH2,CO或CHOR1; L代表CO,CR2R3CO,CH2CH2CO或 CH = CHCO; D表示氢原子,NO 2,NH 2,CO 2 R 4或具有下式[II]的基团:(其中G表示氢原子,OH,SO 2 NH 2,CO 2 R 6,CN或四唑-5-基) E表示氢原子,OH,SO 2 NH 2,CO 2 R 5,CN或四唑-5-基; M表示氢原子,C1-C4低级烷基,硝基或卤素原子; R1,R2,R3,R4,R5和R6彼此独立地为氢原子或C1-C4低级烷基)。 其药理学上可接受的盐或其药学上可接受的溶剂化物,其具有例如对IgE抗体产生的抑制作用,并且可用于预防和/或治疗过敏性疾病。
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公开(公告)号:US20090035185A1
公开(公告)日:2009-02-05
申请号:US12180798
申请日:2008-07-28
IPC分类号: B01L11/00
CPC分类号: B01L9/06 , B01L2200/025 , B01L2200/143 , B01L2200/18 , B01L2300/021 , G01N35/026 , G01N2035/0405 , Y10T436/2575
摘要: A specimen preprocessing system including a specimen rack which supports a specimen container with its opening sealed with a plug for storing the specimen, a carrier line for carrying the specimen rack, a preprocessing unit to which the specimen rack is carried by the carrier line, and a control unit for controlling the carrier line and the preprocessing unit is provided with a plug opening unit which is capable of opening plugs of the specimen containers each having a different height (different plug configuration or diameter) mounted in the same specimen rack.
摘要翻译: 一种样本预处理系统,包括:样本架,其支撑具有用于存储样本的插头开封的检体容器,用于承载标本架的载体线,载体线承载所述检体架的预处理单元; 用于控制载体线和预处理单元的控制单元设置有插头开口单元,该插头开口单元能够打开安装在同一样本架中的具有不同高度(不同插头构型或直径)的样本容器的插头。
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公开(公告)号:US06764650B2
公开(公告)日:2004-07-20
申请号:US09929053
申请日:2001-08-15
IPC分类号: B32B2704
CPC分类号: G01N35/026 , G01N2035/00326 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要: A rack transportation assembly having a projecting member projecting forward is fixed onto a floor by a plurality of adjusters so that its rack transportation surface is brought to a desired level. The projecting member has a first reference surface facing upward. A treatment unit structure having a rack transferring area has a second reference surface in its lower surface. The treatment unit structure is pushed toward the rack transportation assembly under a condition that the second reference surface is lifted upward using height-adjustable casters so as to not become higher than the first reference surface. Then, the treatment unit structure is lowered so that the second reference surface is mounted onto the first reference surface, and a height in the front side of the treatment unit structure is adjusted using the plurality of adjusters.
摘要翻译: 通过多个调节器将具有向前突出的突出部件的机架运输组件固定在地板上,使其齿条运送面达到期望的水平。 突出构件具有面向上的第一参考表面。 具有支架转移区域的处理单元结构在其下表面具有第二参考表面。 处理单元结构在使用高度可调的脚轮向上举起的条件下被推向机架运输组件,使得不会变得高于第一参考表面。 然后,降低处理单元结构,使第二基准面安装在第一基准面上,利用多个调整器调整处理单元结构的前侧的高度。
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公开(公告)号:US08309026B2
公开(公告)日:2012-11-13
申请号:US12180798
申请日:2008-07-28
IPC分类号: G01N21/00
CPC分类号: B01L9/06 , B01L2200/025 , B01L2200/143 , B01L2200/18 , B01L2300/021 , G01N35/026 , G01N2035/0405 , Y10T436/2575
摘要: A specimen preprocessing system includes a determination section for determining with respect to a height of a specimen container; a specimen container lifting mechanism for lifting an opening portion of the specimen container held in a specimen rack to a same predetermined level based on determination information data of the determination section; and a plug opening mechanism for opening a plug of the specimen container lifted to the same predetermined level by the specimen container lifting mechanism.
摘要翻译: 样品预处理系统包括:确定部,用于相对于检体容器的高度进行判定; 标本容器提升机构,用于基于确定部分的确定信息数据将保持在样架中的样本容器的开口部分提升到相同的预定水平; 以及插头打开机构,用于打开由检体容器提升机构提升到相同的预定水平的检体容器的塞子。
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公开(公告)号:US06337050B1
公开(公告)日:2002-01-08
申请号:US09292990
申请日:1999-04-16
IPC分类号: G01N3502
CPC分类号: G01N35/026 , G01N2035/00326 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要: A rack transportation assembly having a projecting member projecting forward is fixed onto a floor by a plurality of adjusters so that its rack transportation surface is brought to a desired level. The projecting member has a first reference surface facing upward. A treatment unit structure having a rack transferring area has a second reference surface in its lower surface. The treatment unit structure is pushed toward the rack transportation assembly under a condition that the second reference surface is lifted upward using height-adjustable casters so as to not become higher than the first reference surface. Then, the treatment unit structure is lowered so that the second reference surface is mounted onto the first reference surface, and a height in the front side of the treatment unit structure is adjusted using the plurality of adjusters.
摘要翻译: 通过多个调节器将具有向前突出的突出部件的机架运输组件固定在地板上,使其齿条运送面达到期望的水平。 突出构件具有面向上的第一参考表面。 具有支架转移区域的处理单元结构在其下表面具有第二参考表面。 处理单元结构在使用高度可调的脚轮向上举起的条件下被推向机架运输组件,使得不会变得高于第一参考表面。 然后,降低处理单元结构,使第二基准面安装在第一基准面上,利用多个调整器调整处理单元结构的前侧的高度。
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公开(公告)号:US06290907B1
公开(公告)日:2001-09-18
申请号:US09150931
申请日:1998-09-10
IPC分类号: G01N3502
CPC分类号: G01N35/026 , G01N35/00712 , G01N35/0092 , G01N2035/00326 , G01N2035/00752 , Y10T436/108331 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831
摘要: A sample handling system comprising: a transportation line including a combination of plural partitive line units; and a plurality of handling units, wherein each of the plural partitive line units and each of the plurality of handling units form a pair, and each handling unit is installed removably from its corresponding partitive line unit. Each handling unit transmits inoperative information to the transportation line when it becomes inoperative. The transportation line transmits this inoperative information to the central controller. The central controller monitors handling units at which the sample rack can stop over. The sample rack avoids stopover at the inoperative handling unit, but is allowed to advance to the subsequent handling unit passing through the partitive line unit which makes a pair with the inoperative handling unit.
摘要翻译: 一种样本处理系统,包括:包括多个分支线单元的组合的输送线; 以及多个处理单元,其中所述多个分立线单元和所述多个处理单元中的每一个形成一对,并且每个处理单元可拆卸地安装在其相应的部分线单元上。 每个处理单元在不工作时将不起作用的信息传送到运输线。 运输线将此无效信息传送给中央控制器。 中央控制器监控样品架可以停止的处理单元。 样品架避免在不操作处理单元中停留,但允许前进到后续的处理单元通过与不操作处理单元成对的部分单元。
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公开(公告)号:US4308778A
公开(公告)日:1982-01-05
申请号:US154079
申请日:1980-05-28
申请人: Katsushi Takahashi
发明人: Katsushi Takahashi
CPC分类号: B26D1/11 , Y10T83/6895
摘要: An improvement on a slicer of the type, for slicing foodstuff into slices of uniform size by causing one group of knife blades supported side by side on respective blade holders to be reciprocated within grooves defined between blade holders having the other group of knife blades supported side by side thereon, wherein all hook members are vertically mounted on the respective blade holders so as to be in the extension of each knife blade.
摘要翻译: 这种类型的切片机的改进是通过使一组刀片并排地支撑在相应的刀片保持器上来将食品切成均匀尺寸的切片,以便在具有另一组刀片支撑侧的刀片保持器之间限定的槽内往复运动 其中所有钩构件垂直地安装在相应的刀片保持器上,以便处于每个刀片的延伸部分中。
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