公开(公告)号：US06844453B2

公开(公告)日：2005-01-18

申请号：US10798338

申请日：2004-03-12

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

IPC分类号： C07D321/00 ,  C07D493/04 ,  C07F7/18 ,  C07D305/14

CPC分类号： C07D493/04 ,  C07D321/00 ,  C07F7/1804

摘要： A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R4R5R6) (wherein each of R4, R5 and R6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R7R8)— (wherein each of R7 and R8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R9R10)SiO— (wherein each of R9 and R10 which are independent of each other, is an alkyl group or an aryl group), each of R1 and R2 is an alkyl group or an aryl group, and R3 is a spacer.

摘要翻译： 式（I）的1,2-二氧杂环丁烷衍生物：其中Ar是可以具有烷基，芳基，卤素原子，烷氧基，羧基，甲酰基，烷基酯的芳基 ，芳基酯，烷基酮，芳基酮或与其结合的杂环，X是能够标记有机化合物或生物分子的取代基或酯，Y是氢原子，酰基或基团的基团 式-Si（R4R5R6）（其中R4，R5和R6各自独立地为烷基或芳基），Z为烷基，芳基，氧原子，硫原子， 羰基， - （CO）-O-，-O-（CO） - ， - NH - ， - NH-CO - ， - CO-NH-，-OSi（R7R8） - （其中R7和R8各自 相互独立，为烷基或芳基）或式 - （R9R10）SiO - （其中R 9和R 10各自独立地为烷基或芳基）的基团， R 1和R 2各自是烷基或芳基，R 3 是间隔物。

公开(公告)号：US06982336B2

公开(公告)日：2006-01-03

申请号：US10091447

申请日：2002-03-07

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

IPC分类号： G01N21/76 ,  C07D261/08 ,  C07D275/02 ,  C07D417/14 ,  C07F7/18

CPC分类号： C07F9/6561 ,  C07F9/65586 ,  G01N33/582 ,  Y10T436/142222

摘要： A 1,2-dioxetane derivative of the formula (I): wherein R1–R3 and Ar are defined in the claims is provided.

摘要翻译： 提供了式（I）的1,2-二氧杂环丁烷衍生物：其中R 1〜R 3和Ar定义在权利要求中。

公开(公告)号：US20050153365A1

公开(公告)日：2005-07-14

申请号：US11000269

申请日：2004-12-01

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

IPC分类号： C07D321/00 ,  C07D493/04 ,  C07F7/18 ,  G01N33/53 ,  C07K16/46 ,  C07D493/02

CPC分类号： C07D493/04 ,  C07D321/00 ,  C07F7/1804

摘要： A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R4R5R6) (wherein each of R4, R5 and R6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R7R8)— (wherein each of R7 and R8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R9R10)SiO— (wherein each of R9 and R10 which are independent of each other, is an alkyl group or an aryl group), each of R1 and R2 is an alkyl group or an aryl group, and R3 is a spacer.

摘要翻译： 式（I）的1,2-二氧杂环丁烷衍生物：其中Ar是可以具有烷基，芳基，卤素原子，烷氧基，羧基，甲酰基，烷基酯的芳基 ，芳基酯，烷基酮，芳基酮或与其结合的杂环，X是能够标记有机化合物或生物分子的取代基或酯，Y是氢原子，酰基或基团的基团 式-Si（R 4 R 5 R 6 R 6）（其中R 4，R 3， 5和R 6彼此独立的是烷基或芳基），Z是烷基，芳基，氧原子，硫原子， 羰基， - （CO）-O-，-O-（CO） - ， - NH - ， - NH-CO - ， - CO-NH-，-OSi（R 7 R' （其中彼此独立的R 7和R 8中的每一个是烷基或芳基）或基团 的式 - （R 9 R 10）SiO - （其中每个R 9

公开(公告)号：US06747160B2

公开(公告)日：2004-06-08

申请号：US10382853

申请日：2003-03-07

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

IPC分类号： C07D40514

CPC分类号： C07D493/04 ,  C07D321/00 ,  C07F7/1804

摘要： A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R4R5R6) (wherein each of R4, R5 and R6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R7R8)— (wherein each of R7 and R8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R9R10)SiO— (wherein each of R9 and R10 which are independent of each other, is an alkyl group or an aryl group), each of R1 and R2 is an alkyl group or an aryl group, and R3 is a spacer.

摘要翻译： 式（I）的1,2-二氧杂环丁烷衍生物：其中Ar是可以具有烷基，芳基，卤素原子，烷氧基，羧基，甲酰基，烷基酯的芳基 ，芳基酯，烷基酮，芳基酮或与其结合的杂环，X是能够标记有机化合物或生物分子的取代基或酯，Y是氢原子，酰基或基团的基团 式-Si（R4R5R6）（其中R4，R5和R6各自独立地为烷基或芳基），Z为烷基，芳基，氧原子，硫原子， 羰基， - （CO）-O-，-O-（CO） - ， - NH - ， - NH-CO - ， - CO-NH-，-OSi（R7R8） - （其中R7和R8各自 相互独立，为烷基或芳基）或式 - （R9R10）SiO - （其中R 9和R 10各自独立地为烷基或芳基）的基团， R 1和R 2各自是烷基或芳基，R 3 是间隔物。

公开(公告)号：US07115757B2

公开(公告)日：2006-10-03

申请号：US11000269

申请日：2004-12-01

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Masashi Yamada

IPC分类号： C07D307/93

CPC分类号： C07D493/04 ,  C07D321/00 ,  C07F7/1804

摘要： A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R4R5R6) (wherein each of R4, R5 and R6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R7R8)— (wherein each of R7 and R8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R9R10)SiO— (wherein each of R9 and R10 which are independent of each other, is an alkyl group or an aryl group), each of R1 and R2 is an alkyl group or an aryl group, and R3 is a spacer.

摘要翻译： 式（I）的1,2-二氧杂环丁烷衍生物：其中Ar是可以具有烷基，芳基，卤素原子，烷氧基，羧基，甲酰基，烷基酯的芳基 ，芳基酯，烷基酮，芳基酮或与其结合的杂环，X是能够标记有机化合物或生物分子的取代基或酯，Y是氢原子，酰基或基团的基团 式-Si（R 4 R 5 R 6 R 6）（其中R 4，R 3， 5和R 6彼此独立的是烷基或芳基），Z是烷基，芳基，氧原子，硫原子， 羰基， - （CO）-O-，-O-（CO） - ， - NH - ， - NH-CO - ， - CO-NH-，-OSi（R 7 R' （其中彼此独立的R 7和R 8中的每一个是烷基或芳基）或基团 的式 - （R 9 R 10）SiO - （其中每个R 9

公开(公告)号：US06228653B1

公开(公告)日：2001-05-08

申请号：US09524003

申请日：2000-03-13

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe

IPC分类号： G01N3300

CPC分类号： C07D493/04 ,  C07F7/1804 ,  Y10T436/142222

摘要： A 1,2-dioxetane derivative represented by the general formula: wherein R1, R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, an alkyl group, or an aryl group, or one or more than one pair of R2 and R3, R4 and R5, and R6 and R7 can together form a cyclic alkyl group. The compound is easily handled because the compound itself is very stable, and it is capable of emitting light with a very high efficiency.

摘要翻译： 由以下通式表示的1,2-二氧环乙烷衍生物：其中R1，R2，R3，R4，R5，R6和R7各自独立地表示氢原子，烷基或芳基，或一个或多于一个 R2和R3，R4和R5，R6和R7可以一起形成环烷基。 化合物易于处理，因为化合物本身非常稳定，并且能够以非常高的效率发光。

公开(公告)号：US5393780A

公开(公告)日：1995-02-28

申请号：US217566

申请日：1994-03-25

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Eiko Mori ,  Miwa Ishihara ,  Tetsuaki Yamaura ,  Misao Aoyama ,  Hiroshi Ikawa ,  Hisako Kobayashi

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Eiko Mori ,  Miwa Ishihara ,  Tetsuaki Yamaura ,  Misao Aoyama ,  Hiroshi Ikawa ,  Hisako Kobayashi

IPC分类号： C07C45/44 ,  C07C47/277 ,  C07C59/64 ,  C07C69/734 ,  C07D213/30 ,  C07D309/12 ,  C07D309/30 ,  A01N37/10

CPC分类号： C07D213/30 ,  C07C45/44 ,  C07C47/277 ,  C07C59/64 ,  C07C69/734 ,  C07D309/12 ,  C07D309/30

摘要： A 4-fluorobiphenyl derivative of formula (I): ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group of formula (II): ##STR2## wherein R.sup.2 is a hydrogen atom, an alkyl group, an alkaline metal or an alkaline earth metal; a tetrahydropyranyl group of formula (III): ##STR3## or a .omega.-oxycarbonyl-3-oxobutyl group of formula (IV): ##STR4## wherein R.sup.3 is an alkyl group; R.sup.1 is an alkyl group. This 4-fluorobiphenyl derivative is useful as an effective component for a cholesterol or lipid lowering agent.

摘要翻译： 式（I）的4-氟联苯衍生物：其中A是式（II）的ω-氧羰基二羟基丁基：其中R 2是氢原子，烷基，碱 金属或碱土金属; 式（Ⅳ）的四氢吡喃基：式（Ⅳ）的化合物：其中R 3为烷基; R1是烷基。 该4-氟联苯衍生物可用作胆固醇或降脂剂的有效成分。

公开(公告)号：US06218135B1

公开(公告)日：2001-04-17

申请号：US09267604

申请日：1999-03-15

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe

IPC分类号： G01N33535

CPC分类号： C07D493/04 ,  Y10S436/805

摘要： The present invention has its objects to provide a compound not only which is easy to handle, thermally stable, and high in emission efficiency, but also which can show high emission efficiency without coexisting enhancer in the system even in a protic solvent. The present invention is related to a 1,2-dioxetane derivative of general formula (I). [wherein R1, R2, R3, R4 and R5 each independently represents hydrogen, alkyl or aryl; a pair of R2 and R3 and a pair of R4 and R5 may respectively be joined to each other to form a cycloalkyl group.

摘要翻译： 本发明的目的是提供一种化合物，其不仅易于处理，热稳定，发光效率高，而且即使在质子溶剂中也可以在体系中即使在共存​​增强剂中也能显示高发射效率。本发明 与通式（I）的1,2-二氧环乙烷衍生物有关。[其中R1，R2，R3，R4和R5各自独立地表示氢，烷基或芳基; 一对R 2和R 3以及一对R 4和R 5可以分别彼此连接以形成环烷基。

公开(公告)号：US5266707A

公开(公告)日：1993-11-30

申请号：US946533

申请日：1992-09-17

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Eiko Mori ,  Tetsuaki Yamaura ,  Misao Aoyama

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe ,  Eiko Mori ,  Tetsuaki Yamaura ,  Misao Aoyama

IPC分类号： C07D307/79 ,  C07D405/04 ,  C07D405/14 ,  C07D407/06 ,  C07D309/30 ,  C07D307/80

CPC分类号： C07D307/79 ,  C07D405/04 ,  C07D405/14 ,  C07D407/06

摘要： 4-hydroxytetrahydropyran-2-one and 3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: ##STR1## wherein R.sup.1 represents hydrogen, a nitro group, or -N(R.sup.4)R.sup.5 in which R.sup.4 and R.sup.5 each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R.sup.4 and R.sup.5 may be combined to form a cyclic amino group; and R.sup.2 and R.sup.3 each represent hydrogen or an alkyl group; and R.sup.6 represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.

公开(公告)号：US4558143A

公开(公告)日：1985-12-10

申请号：US520519

申请日：1983-08-04

申请人： Masakatsu Matsumoto ,  Nobuko Watanabe

发明人： Masakatsu Matsumoto ,  Nobuko Watanabe

IPC分类号： C07D307/77 ,  C07D307/79

CPC分类号： C07D307/79

摘要： A 4-oxo-4,5,6,7-tetrahydrobenzofuran derivative is prepared by reacting a 1,3-cyclohexanedione derivative with chloroacetaldehyde in the presence of a base while maintaining the reaction mixture at a pH of from 4 to 10, and treating the reaction mixture with an acid. The 4-oxo-4,5,6,7-tetrahydrobenzofuran derivatives are useful as an intermediate for synthesis of various kinds of drugs.

摘要翻译： 4-氧代-4,5,6,7-四氢苯并呋喃衍生物通过使1,3-环己二酮衍生物与氯乙醛在碱的存在下反应而制备，同时保持反应混合物的pH为4至10，并处理 反应混合物与酸反应。 4-氧代-4,5,6,7-四氢苯并呋喃衍生物可用作合成各种药物的中间体。