公开(公告)号：US06884821B1

公开(公告)日：2005-04-26

申请号：US10088916

申请日：2000-09-29

申请人： Masanobu Shinoda ,  Eita Emori ,  Fumiyoshi Matsuura ,  Toshihiko Kaneko ,  Norihito Ohi ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Sadakazu Miyashita ,  Taro Hibara ,  Takashi Seiki ,  Richard Clark ,  Hitoshi Harada

发明人： Masanobu Shinoda ,  Eita Emori ,  Fumiyoshi Matsuura ,  Toshihiko Kaneko ,  Norihito Ohi ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Sadakazu Miyashita ,  Taro Hibara ,  Takashi Seiki ,  Richard Clark ,  Hitoshi Harada

IPC分类号： C07C59/66 ,  C07C59/68 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C235/60 ,  C07C235/78 ,  C07C235/84 ,  C07C255/57 ,  C07D209/14 ,  C07D209/42 ,  C07D213/30 ,  C07D213/55 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D215/04 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/52 ,  C07D241/24 ,  C07D261/18 ,  C07D263/26 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/56 ,  C07D307/54 ,  C07D307/79 ,  C07D333/24 ,  C07D401/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  A61K31/192 ,  C07C59/64

CPC分类号： C07D213/30 ,  C07C59/66 ,  C07C59/68 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C235/60 ,  C07C235/78 ,  C07C235/84 ,  C07C255/57 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/14 ,  C07D209/42 ,  C07D213/55 ,  C07D213/56 ,  C07D213/81 ,  C07D213/82 ,  C07D215/04 ,  C07D217/26 ,  C07D231/14 ,  C07D233/90 ,  C07D239/52 ,  C07D241/24 ,  C07D261/18 ,  C07D263/26 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/56 ,  C07D307/54 ,  C07D307/79 ,  C07D333/24 ,  C07D401/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(RW1)RW2, or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.

摘要翻译： 通式（I）的新型羧酸衍生物，它们的盐，它们的酯，或它们的水合物，其可用作胰岛素抵抗性改良剂; 和含有衍生物作为活性成分的药物。 在所述式中，R 1是氢，羟基，烷基等; L是单键，双键，亚烷基等; M是单键，亚烷基等; T是单键，亚烷基等; W是羧基，-CON（R W1），W 2，W 2等; <？img id =“CUSTOM-CHARACTER-00001”he =“2.46mm”wi =“6.01mm”file =“US06884821-20050426-P00900.TIF”alt =“custom character”img-content =“character”img- format =“tif”？>表示单键或双键; X是氧，亚烯基等; Y是可以含有杂原子的芳族烃基等; Z是可以含有杂原子的芳族烃基。

公开(公告)号：US20100168014A1

公开(公告)日：2010-07-01

申请号：US12591105

申请日：2009-11-09

申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Toru Arai

发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Toru Arai

IPC分类号： A61K38/22 ,  G01N33/53

CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

摘要翻译： 本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等 在管理之后。 根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。

公开(公告)号：US07638490B2

公开(公告)日：2009-12-29

申请号：US10588542

申请日：2005-02-09

申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

IPC分类号： A61K38/00 ,  A01N37/18

CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

摘要： Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

摘要翻译： 发现松弛素-3在给予松弛素-3后，通过观察饲喂量，体重和脂肪重量，通过大鼠脑室内施用，具有摄食刺激活性，体重增加活性和脂肪增加活性。 本发明包括：具有刺激喂养，增加体重和育肥的有效作用的多肽; 含有该多肽的治疗剂; 筛选活化或抑制多肽受体的化合物，物质或其盐的方法; 一套筛选工具; 以及具有抑制多肽表达的物质，例如进食抑制剂，治疗肥胖症的治疗剂和用于治疗糖尿病的治疗剂的药剂。

公开(公告)号：US20070122845A1

公开(公告)日：2007-05-31

申请号：US11522025

申请日：2006-09-15

申请人： Tetsu Kawano ,  Junro Kuromitsu ,  Akiko Hamaguchi ,  Keiko Yamaguchi ,  Takashi Seiki ,  Kazuma Takase

发明人： Tetsu Kawano ,  Junro Kuromitsu ,  Akiko Hamaguchi ,  Keiko Yamaguchi ,  Takashi Seiki ,  Kazuma Takase

IPC分类号： C40B30/06 ,  C40B40/02 ,  C40B40/04 ,  A01K67/027

CPC分类号： G01N33/505 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/04

摘要： The present invention provides methods for identifying a GPR83 agonist capable of stimulating a regulatory T cell function and methods for identifying a GPR83 antagonist capable of suppressing a regulatory T cell function.

摘要翻译： 本发明提供鉴定能够刺激调节性T细胞功能的GPR83激动剂的方法以及鉴定能够抑制调节性T细胞功能的GPR83拮抗剂的方法。

公开(公告)号：US20070054850A1

公开(公告)日：2007-03-08

申请号：US10588542

申请日：2005-02-09

申请人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

发明人： Takayuki Hida ,  Tomoko Sekiya ,  Toru Sawai ,  Takashi Seiki ,  Eiki Takahashi ,  Michiko Kosasa ,  Kokichi Harada ,  Tohru Arai

IPC分类号： A61K38/22 ,  G01N33/53

CPC分类号： A61K38/17 ,  G01N33/566 ,  G01N2500/04 ,  Y02A50/406

摘要： The present inventors have found that relaxin-3 has a feeding-stimulating activity, a body weight increasing activity, and fat weight increasing activity by intracerebroventricularly administering relaxin-3 to rats and observing the amount of feeding, body weight and fat weight, and so on after the administration. According to the present invention, a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing said polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of said polypeptide; a kit for said screening; and an agent which comprises a substance which inhibits expression of said polypeptide, such as a feeding-surpressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

摘要翻译： 本发明人已经发现松弛素-3具有喂养刺激活性，体重增加活性和通过脑内给予松弛素-3对大鼠的体重增加活性，观察喂养量，体重和脂肪重量等 在管理之后。 根据本发明，具有刺激进食，增加体重和育肥的有效作用的多肽; 含有所述多肽的治疗剂; 筛选活化或抑制所述多肽受体的化合物，物质或其盐的方法; 用于筛选的试剂盒; 以及包含抑制所述多肽表达的物质的试剂，例如饲料抑制剂，治疗肥胖症的治疗剂和治疗糖尿病的治疗剂。