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    GENERATING METHOD AND GENERATOR FOR GENERATING MIST OR FINE-BUBBLE BY USING SURFACE ACOUSTIC WAVE
    1.
    发明申请
    GENERATING METHOD AND GENERATOR FOR GENERATING MIST OR FINE-BUBBLE BY USING SURFACE ACOUSTIC WAVE 审中-公开
    通过使用表面声波产生雾化器或微泡的产生方法和发生器

    公开(公告)号：US20120097752A1

    公开(公告)日：2012-04-26

    申请号：US13379358

    申请日：2010-06-02

    申请人： Masanori Okano ,  Shigeki Fujiwara ,  Youhei Ishigami

    发明人： Masanori Okano ,  Shigeki Fujiwara ,  Youhei Ishigami

    IPC分类号： B05B17/00 ,  B05B1/08

    CPC分类号： B01F11/0258 ,  B01F3/0407 ,  B01F3/04978 ,  B05B17/0607 ,  B05B17/0615 ,  B06B1/0644 ,  B08B3/10 ,  H01L41/09

    摘要： In a generating method and a generator of mist or fine-bubble, with a simple and small configuration, application into a wide range kind of liquid is enabled, and generating stably the mist or the fine-bubbles or both is enabled. The generator is provided with a piezoelectric substrate which equips two or more comb-like electrodes on a surface and arranged so that the surface may intersect the mutual interface of the gas and the liquid and a part of piezoelectric substrate is put in a liquid, and a surface acoustic wave excited on the surface with the electrode is made to propagate along the surface so that may exist in the upper and lower sides of an interface. The surface acoustic wave generates mist in the gas side which is above the interface, and generates fine-bubbles in the liquid side which is below the interface. Since the mist and the fine-bubbles are generated with the surface acoustic wave, without being based on mechanical operation for generating a turning stream, the mist and the fine-bubbles can be stably generated in the simple and small configuration.

    摘要翻译： 在雾化或微细气泡的发生方法和发生器中，具有简单且小型的构造，能够应用于宽范围的液体，并且能够稳定地产生雾或微小气泡或两者。 发电机设置有压电基板，其在表面上配置两个或更多个梳状电极，并且布置成使得该表面可以与气体和液体的相互接口相交，并且一部分压电基板被放入液体中，并且 使在电极表面激发的表面声波沿着表面传播，从而可能存在于界面的上侧和下侧。 表面声波在界面上方的气体侧产生雾，并在界面下方的液体侧产生微小气泡。 由于通过表面声波产生雾和微小气泡，而不是基于用于产生转向流的机械操作，所以能够以简单且小型的结构稳定地产生雾和微小气泡。

    DRIVE DEVICE, AND MOVEMENT MECHANISM USING DRIVE DEVICE
    2.
    发明申请
    DRIVE DEVICE, AND MOVEMENT MECHANISM USING DRIVE DEVICE 审中-公开
    驱动装置和使用驱动装置的运动机构

    公开(公告)号：US20130038145A1

    公开(公告)日：2013-02-14

    申请号：US13577545

    申请日：2011-02-16

    申请人： Shigeki Fujiwara ,  Youhei Ishigami ,  Yoshio Mitsutake ,  Satoshi Suzuki

    发明人： Shigeki Fujiwara ,  Youhei Ishigami ,  Yoshio Mitsutake ,  Satoshi Suzuki

    IPC分类号： H02K33/16 ,  H02K33/18

    CPC分类号： H02K33/16 ,  H01F7/066 ,  H01F7/122 ,  H01F7/14 ,  H01F7/1646

    摘要： A drive device which provides an electromagnetic impact and a movement mechanism using the drive device to achieve a reciprocating movement with a compact and simple configuration. A drive device provides an impact to an object-to-be-moved supported by a friction surface and moves the object-to-be-moved, and includes an electromagnetic coil, a permanent magnet, a stopper, and a control device which controls the electromagnetic coil. The permanent magnet relatively moves to the electromagnetic coil by an action caused by an electrical current supply to the electromagnetic coil. When the electrical current is supplied to the electromagnetic coil, the permanent magnet collides with the electromagnetic coil or the stopper, which forms the collided-body, and generates the impact. The impact can be generated in any direction, then a reciprocating movement of the object-to-be-moved can be achieved.

    摘要翻译： 提供电磁冲击的驱动装置和使用该驱动装置的移动机构以紧凑且简单的结构实现往复运动。 驱动装置对由摩擦表面支撑的被移动体提供冲击并移动待移动物体，并且包括电磁线圈，永磁体，止动器和控制装置 电磁线圈。 永磁体通过由电磁线圈的电流供给引起的动作相对地移动到电磁线圈。 当向电磁线圈提供电流时，永久磁铁与形成碰撞体的电磁线圈或塞子碰撞并产生冲击。 可以在任何方向上产生冲击，然后可以实现待移动物体的往复运动。

    DRIVE DEVICE, AND MOVEMENT MECHANISM USING DRIVE DEVICE
    3.
    发明申请
    DRIVE DEVICE, AND MOVEMENT MECHANISM USING DRIVE DEVICE 审中-公开
    驱动装置和使用驱动装置的运动机构

    公开(公告)号：US20130009492A1

    公开(公告)日：2013-01-10

    申请号：US13577524

    申请日：2011-02-16

    申请人： Shigeki Fujiwara ,  Youhei Ishigami ,  Yoshio Mitsutake ,  Satoshi Suzuki

    发明人： Shigeki Fujiwara ,  Youhei Ishigami ,  Yoshio Mitsutake ,  Satoshi Suzuki

    IPC分类号： H02K41/02

    CPC分类号： H02K33/16 ,  H02K33/12

    摘要： A drive device includes two integrated electromagnetic coils separated on an axis, an elastic body, and two movable electric conductors. An object-to-be-moved is moved to left with an operation of a left group which includes one electromagnetic coil and one conductor. A first conductor is repulsively moved to right by a repulsion force caused by an eddy current generated on the first conductor with an electrical current-supply to a first electromagnetic coil and then, the elastic body is compressed by the first conductor and subsequently pushes back the first conductor. At this time, the electrical current-supply to the first electromagnetic coil is turned off, and the first conductor collides with the first electromagnetic coil, and this collision generates a leftward impact. The left and right groups enable a left-right reciprocating movement.

    摘要翻译： 驱动装置包括在轴上分离的两个集成电磁线圈，弹性体和两个可移动导电体。 用左电子线的操作将待移动的物体移动到左侧，其中包括一个电磁线圈和一个导体。 第一导体通过由在第一导体上产生的涡流引起的排斥力向第一导体排斥，向第一电磁线圈提供电流供应，然后弹性体被第一导体压缩并随后推回 第一指挥 此时，关闭第一电磁线圈的电流供应，并且第一导体与第一电磁线圈碰撞，并且该碰撞产生向左的冲击。 左右组可进行左右往复运动。

    Benzotriazines having adenosine uptake inhibitor activity
    5.
    发明授权
    Benzotriazines having adenosine uptake inhibitor activity 失效
    具有腺苷摄取抑制剂活性的苯并三嗪

    公开(公告)号：US5605900A

    公开(公告)日：1997-02-25

    申请号：US430227

    申请日：1995-04-28

    申请人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    发明人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    IPC分类号： C07D401/14 ,  C07D491/04 ,  C07D401/04 ,  A61K31/445 ,  A61K31/50 ,  A61K31/53

    CPC分类号： C07D401/14 ,  C07D491/04

    摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C-R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.

    摘要翻译： 本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物： （I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级 烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

    Quinazoline derivatives
    6.
    发明授权
    Quinazoline derivatives 失效
    喹唑啉衍生物

    公开(公告)号：US5948784A

    公开(公告)日：1999-09-07

    申请号：US89255

    申请日：1998-06-03

    申请人： Shigeki Fujiwara ,  Yuko Okamura ,  Haruki Takai ,  Hiromi Nonaka ,  Takahiro Moriyama ,  Kozo Yao ,  Akira Karasawa

    发明人： Shigeki Fujiwara ,  Yuko Okamura ,  Haruki Takai ,  Hiromi Nonaka ,  Takahiro Moriyama ,  Kozo Yao ,  Akira Karasawa

    IPC分类号： A61K31/505 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D401/14

    CPC分类号： C07D401/14

    摘要： Disclosed are quinazoline derivatives represented by formula (I): wherein R.sup.1 represents hydrogen, lower alkyl, alkenyl, or aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, or the like; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 represent hydrogen, lower alkyl, lower alkoxy, aralkyloxy, or the like, or any adjoining two of them are combined to form methylenedioxy or the like; R.sup.10 represents hydrogen, lower alkyl, or the like; R.sup.11 and R.sup.12 represent hydrogen, lower alkyl, cycloalkyl, phenyl, or aralkyl, or R.sup.11 and R.sup.12 are combined together with N to form a heterocyclic group; and n represents 0, 1 or 2, and pharmaceutically acceptable salts thereof. These compounds have adenosine uptake inhibitory activity and are useful for the protection of myocardium and for the prevention or treatment of renal diseases such as nephritis and diabetic nephropathy.

    摘要翻译： 公开了由式（I）表示的喹唑啉衍生物：其中R1表示氢，低级烷基，烯基或芳烷基; R2，R3，R4和R5代表氢，低级烷基，低级烷氧基，低级烷酰基等; R 6，R 7，R 8和R 9表示氢，低级烷基，低级烷氧基，芳烷氧基等，或者其中任意相邻的两个相结合形成亚甲二氧基等; R 10表示氢，低级烷基等; R 11和R 12表示氢，低级烷基，环烷基，苯基或芳烷基，或R 11和R 12与N一起形成杂环基; 和n表示0,1或2，及其药学上可接受的盐。 这些化合物具有腺苷摄取抑制活性，可用于保护心肌和预防或治疗肾脏疾病如肾炎和糖尿病肾病。

    Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors
    7.
    发明授权
    Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors 失效
    哌啶基 - 二氧喹唑啉作为腺苷再摄取抑制剂

    公开(公告)号：US5624926A

    公开(公告)日：1997-04-29

    申请号：US318876

    申请日：1994-10-17

    申请人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    发明人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    IPC分类号： C07D401/14 ,  C07D491/04 ,  A61K31/50 ,  A61K31/505

    CPC分类号： C07D401/14 ,  C07D491/04

    摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.

    摘要翻译： PCT No.PCT / JP94 / 00229 Sec。 371日期：1994年10月17日 102（e）日期1994年10月17日PCT 1994年2月16日PCT PCT。 WO94 / 19342 PCT公开号 日期：1994年9月1日本发明涉及一种腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物 式（I）：其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级 烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

    Quinazolines and phthalazines having adenosine uptake inhibitor activity
    9.
    发明授权
    Quinazolines and phthalazines having adenosine uptake inhibitor activity 失效
    喹唑啉和具有腺苷摄取抑制剂活性的酞嗪酮

    公开(公告)号：US5648353A

    公开(公告)日：1997-07-15

    申请号：US446235

    申请日：1995-05-22

    申请人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    发明人： Shigeki Fujiwara ,  Daisuke Machii ,  Haruki Takai ,  Hiromi Nonaka ,  Hiroshi Kase ,  Kozo Yao ,  Michiyo Kawakage ,  Hideaki Kusaka ,  Akira Karasawa

    IPC分类号： C07D401/14 ,  C07D491/04 ,  C07D401/04 ,  A61K31/445 ,  A61K31/50 ,  A61K31/505

    CPC分类号： C07D401/14 ,  C07D491/04

    摘要： The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),or a pharmaceutically acceptable salt thereof as an active ingredient.

    摘要翻译： 本发明涉及腺苷摄取抑制剂和用于心肌保护或预防或治疗炎性水肿的药剂，其包含由式（I）表示的1,2,3,4-四氢-2,4-二氧代喹唑啉衍生物： （I）其中R 1表示氢，取代或未取代的低级烷基，烯基或取代或未取代的芳烷基; R2，R3，R4和R5独立地表示氢，卤素，氨基，一或二（低级烷基）氨基，低级烷酰基氨基，硝基，氰基，取代或未取代的低级烷基，羟基，低级烷氧基，低级烷硫基，羧基，低级 烷氧基羰基，低级烷酰基，芳烷氧基或低级烷酰氧基; R 6，R 7，R 8和R 9独立地表示氢，羟基，取代或未取代的低级烷氧基或芳烷氧基，或者它们中的任何相邻的两个被结合形成亚甲二氧基; R 10表示氢或低级烷基; 并且Y和Z独立地表示作为活性成分的N或C-R11（其中R11表示氢，取代或未取代的低级烷基或卤素）或其药学上可接受的盐。

    Precision drilling method
    10.
    发明授权
    Precision drilling method 失效
    精密钻孔法

    公开(公告)号：US5336024A

    公开(公告)日：1994-08-09

    申请号：US018392

    申请日：1993-02-17

    申请人： Teruo Nakagawa ,  Shigeki Fujiwara

    发明人： Teruo Nakagawa ,  Shigeki Fujiwara

    IPC分类号： B23B35/00 ,  B23Q15/013

    CPC分类号： B23B35/00 ,  B23Q15/013 ,  G05B2219/41355 ,  G05B2219/45208 ,  G05B2219/49096 ,  G05B2219/49271 ,  Y10T408/03 ,  Y10T408/16 ,  Y10T408/175

    摘要： In a precision drilling method for drilling a straight hole in a work with a drill, a drill unit for rotating the drill is supported to a housing in suspension by an electromagnetic force consisting of separately controllable restoring and damping elements. The drill unit is supported by first restoring and damping elements such that a positional displacement of the drill unit is permitted to relieve a contacting pressure applied to the drill unit when the drill comes into contact with the work. The positional displacement of the drill unit is monitored by sensors. When a force applied to the drill unit, which is determined according to thus monitored displacement, is greater than a critical value, the first restoring element is increased to give a relatively strong support capable of rapidly restoring the position of the drill unit, and preferably the first damping element is also increased to rapidly damp a vibration of the drill unit induced by the positional displacement. Subsequently, the straight hole is drilled in the work with the drill by feeding the housing toward the work. As a result, it is possible to form the straight hole precisely at a desired position in the work without causing a breakage of the drill.

    摘要翻译： 在用钻头对工件进行钻孔的精密钻孔方法中，用于使钻头旋转的钻孔单元通过由单独可控的恢复和阻尼元件组成的电磁力支撑在悬挂的壳体中。 钻机单元由第一恢复和阻尼元件支撑，使得当钻头与工件接触时，允许钻机单元的位置偏移以减轻施加到钻机单元的接触压力。 钻机单元的位置位移由传感器监控。 当施加到根据如此监测的位移确定的钻机单元的力大于临界值时，第一恢复元件增加以提供能够快速恢复钻机单元的位置的相对较强的支撑件，并且优选地 第一阻尼元件也被增加以快速地抑制由位置偏移引起的钻孔单元的振动。 随后，通过将壳体朝向工件进给，在钻孔的工作中钻直孔。 结果，可以在工件中的期望位置处精确地形成直孔，而不会引起钻头的破损。