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公开(公告)号：US07544781B2
公开(公告)日：2009-06-09
申请号：US11878724
申请日：2007-07-26
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide: (1) X-(Pro-Y-Gly)n-OH, wherein: X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Y represents Pro or Hyp, and n denotes an integer of 1 to 20; (2) X-(Z)r—OH, wherein X represents H or the group HOOC—(CH2)m—CO— and m denotes an integer of 1 to 18, Z represents a peptide chain comprising 1 to 10 amino acid residue(s), and r denotes an integer of 1 to 20; and (3) H2N—R—NH2, wherein R represents a linear or branched alkylene group; and further wherein the ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %); provided that in the case where X represents the group HOOC—(CH2)m—CO— and m has the same meaning as defined above in formula (1) and/or (2), the amount of compound (C) is substantially 1 mol relative to 1 mol of the total molar amount of peptide component (A) and/or peptide component (B); and in the case where X represents H in the formula (1) and/or (2), the reaction is conducted without compound (C).
摘要翻译： 通过使下述式（1）表示的肽组分（A）与下式（2）表示的肽组分（B）和任选的下述式（3）表示的化合物（C）反应来制备多肽的方法 ，得到所述多肽：（1）X-（Pro-Y-Gly）n -OH，其中：X表示H或HOOC-（CH 2）m -CO-，m表示1〜18的整数，Y 表示Pro或Hyp，n表示1〜20的整数， （2）X-（Z）r-OH，其中X表示H或HOOC-（CH 2）m -CO-基团，m表示1至18的整数，Z表示包含1至10个氨基酸残基的肽链 （s），r表示1〜20的整数， 和（3）H 2 N-R-NH 2，其中R表示直链或支链亚烷基; 并且其中所述肽组分（A）相对于肽组分（B）的比例为100/0至30/70（摩尔％）; 条件是在X表示基团HOOC-（CH 2）m -CO-和m具有与上述式（1）和/或（2）中所定义相同的含义的情况下，化合物（C）的量基本上为1 相对于肽组分（A）和/或肽组分（B）的总摩尔量的1mol; 在式（1）和/或（2）中X表示H的情况下，反应不进行化合物（C）。
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公开(公告)号：US5770229A
公开(公告)日：1998-06-23
申请号：US826097
申请日：1997-03-24
申请人： Masao Tanihara , Hisao Kinoshita
发明人： Masao Tanihara , Hisao Kinoshita
IPC分类号： A61K47/48 , A61L15/44 , A61L15/60 , A61L26/00 , A61L27/54 , A61L31/14 , A61L31/16 , A61K9/10
CPC分类号： A61L31/145 , A61K47/48784 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L27/54 , A61L31/16 , A61L2300/00 , A61L2300/602 , Y10S514/944
摘要： A medical polymer gel produced by immobilizing a drug onto a water swelling polymer gel through a cleavable group with the main chain to be cleaved via an enzymatic reaction and a spacer, and a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. Because the medical polymer gel exerts a drug releasing property depending on the level of an enzyme, the gel can release a therapeutically effective dose of a drug only at a focal lesion generating the enzyme. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.
摘要翻译： 一种医用聚合物凝胶，其通过可裂解的基团将药物固定在水溶胀性聚合物凝胶上，通过酶反应和间隔物将待裂解的主链和通过共价交联具有羧基的多糖而产生的水溶性聚合物凝胶 在分子内具有二氨基烷烃衍生物作为交联剂。 由于医用聚合物凝胶根据酶的水平发挥药物释放性质，所以凝胶只能在产生酶的局灶性病变处释放治疗有效剂量的药物。 医用聚合物凝胶可用作伤口敷料的结构组分，用于生物组织的粘合剂，防粘连剂，骨增强剂和药物释放基材。 包含本发明的水溶性聚合物凝胶的结构材料的伤口敷料可以应用于患有伤口，烧伤和褥疮的患者，以促进患者的伤口的愈合。
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公开(公告)号：US5679371A
公开(公告)日：1997-10-21
申请号：US569351
申请日：1995-12-08
摘要： The present invention provides a wound dressing composed of a hydrogel with the principal component being a vinyl alcohol polymer of a viscosity average polymerization degree of 300 or more, wherein the vinyl alcohol polymer contains 5 to 50 mol % of one or more vinyl ester units represented by the following formula (I): ##STR1## and the vinyl alcohol polymer has a block character (.eta.) of 0.6 or less, the block character being represented by the following mathematical formula (II); .eta.=�OH, VES!/2�OH!�VES! (II) Because the wound dressing of the present invention is excellent in terms of transparency, flexibility, hot water resistance, water absorption, and safety, the dressing is useful for the treatment and promotion of the healing of wounds including general wounds such as abrasions, cuts and acne; surgery wounds such as excision wounds and dermabrasions; burns; ulcers; and pressure sores.
摘要翻译： 本发明提供一种由水凝胶构成的伤口敷料，主要成分为粘均聚合度为300以上的乙烯醇聚合物，其中乙烯醇聚合物含有5〜50摩尔％的一种或多种乙烯基酯单元 通过下式（I）表示：乙烯醇聚合物的嵌段特性（η）为0.6以下，嵌段特征由下述数学式（II）表示。 eta = [OH，VES] / 2 [OH] [VES]（II）因为本发明的伤口敷料在透明性，柔韧性，耐热水性，吸水性和安全性方面优异，所以该敷料可用于 治疗和促进伤口愈合，包括一般伤口如擦伤，切口和痤疮; 手术伤口如切口伤口和皮肤损伤; 烧伤 溃疡 和压疮。
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公开(公告)号：US20080009604A1
公开(公告)日：2008-01-10
申请号：US11878724
申请日：2007-07-26
IPC分类号： C07K1/02
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where “X” represents HOOC—(CH2)m—CO— in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol %), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B). X-(Pro-Y-Gly)n-OH (1a), X—(Z)r—OH (2a), H2N—R—NH2 (3a) Wherein “X” represents H or the group HOOC—(CH2)m—CO— (“m”=1 to 18), “Y” represents Pro or Hyp, “n”=1 to 20, “Z” represents a peptide chain comprising 1 to 10 amino acid residue(s), “r”=1 to 20, and “R” represents a linear or branched alkylene group. The present invention provides a collagenous polypeptide which is free from a risk of an infection by a pathogenic organism (or a causative factor) or an undesirable side effect, and which has a high safety.
摘要翻译： 将由下式（1a）表示的肽成分（B）表示的肽成分（A）和下述式（3a）表示的化合物（C））作为任意成分进行 在脱水缩合剂和冷凝助剂的存在下进行缩合反应; 条件是在“X”表示式（1a）和/或（2a）中的HOOC-（CH 2）m - CO-）的情况下，反应是 与化合物（C）进行反应。 肽成分（A）相对于肽成分（B）的比例为100/0〜30/70（摩尔％），化合物（C）相对于肽成分的总摩尔量 A）和/或肽组分（B）。 X-（Pro-Y-Gly）n -OH（1a），X-（Z）-OH（2a），H 2 其中，“X”表示H或HOOC-（CH 2）m -CO-（“ m“= 1〜18），”Y“表示Pro或Hyp，”n“= 1〜20，”Z“表示包含1〜10个氨基酸残基，”r“= 1〜20， “R”表示直链或支链亚烷基。 本发明提供一种胶原多肽，其不具有致病生物（或致病因子）感染的风险或不期望的副作用，并且具有高安全性。
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公开(公告)号：US20070224251A1
公开(公告)日：2007-09-27
申请号：US11385750
申请日：2006-03-22
CPC分类号： A61K38/4833 , A61L15/225 , A61L15/32 , A61L24/043 , A61L24/10 , A61L2400/04
摘要： The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5×104 to 100×104 in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.
摘要翻译： 本发明提供止血性，生物降解性和生物吸收性，质量的均匀性和稳定性优异的止血材料，并且降低了来自动物的病原体的污染的风险。 止血材料包含能够形成三重螺旋结构的凝血酶和合成多肽。 多肽可以在分子量分布中显示分子量在5×10 4至100×10 4范围内的峰。 多肽可以至少含有由下式表示的肽单元：-Pro-X-Gly-（在该式中，X表示Pro或Hyp）。 凝血酶可以是重组体。 在止血材料中，相对于1mg多肽，凝血酶的比例可以为约0.1至500单位（U）。 止血材料还可以包含具有生物降解性和生物吸收性的粘合剂组分。 止血材料可以形成在基底上。
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6.发明授权Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane 失效羧基多糖和二氨基烷烃的医用交联聚合物凝胶
公开(公告)号：US5658592A
公开(公告)日：1997-08-19
申请号：US571976
申请日：1996-01-16
申请人： Masao Tanihara , Hisao Kinoshita
发明人： Masao Tanihara , Hisao Kinoshita
IPC分类号： A61K47/48 , A61L15/44 , A61L15/60 , A61L26/00 , A61L27/54 , A61L31/14 , A61L31/16 , A61K9/10
CPC分类号： A61L31/145 , A61K47/48784 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L27/54 , A61L31/16 , A61L2300/00 , A61L2300/602 , Y10S514/944
摘要： A water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.
摘要翻译： PCT No.PCT / JP95 / 00873 Sec。 371日期1996年1月16日 102（e）日期1996年1月16日PCT提交1995年5月8日PCT公布。 WO95 / 31223 PCT出版物 日期：1995年11月23日通过在分子内共价交联具有羧基的多糖与二氨基烷烃衍生物作为交联剂而制得的水溶胀性聚合物凝胶。 医用聚合物凝胶可用作伤口敷料的结构组分，用于生物组织的粘合剂，防粘连剂，骨增强剂和药物释放基材。 包含本发明的水溶性聚合物凝胶的结构材料的伤口敷料可以应用于患有伤口，烧伤和褥疮的患者，以促进患者的伤口的愈合。
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7.发明申请Synthetic polypeptide-containing bioapplicable material and film-forming material 审中-公开含合成多肽的生物应用材料和成膜材料公开(公告)号：US20070207180A1
公开(公告)日：2007-09-06
申请号：US11365832
申请日：2006-03-02
CPC分类号： A61K38/16 , C07K5/0823
摘要： The present invention provides a bioapplicable material (or composition) or film-forming material (or composition), which is free from a risk of an infection by a pathogenic organism or a transmission of a causative factor, has a high safety. The material (or composition) comprises a collagen-like synthetic polypeptide having at least an amino acid sequence represented by the formula -Pro-Y-Gly- (wherein Y represents Pro or Hyp). The polypeptide may show positive Cotton effect at a wavelength in range of 220 to 230 nm and negative Cotton effect at a wavelength in range of 195 to 205 nm in a circular dichroism spectrum. At least part of the polypeptide may be capable of forming a triple helical structure. The polypeptide may be degradable with a collagenase.
摘要翻译： 本发明提供了一种生物应用材料（或组合物）或成膜材料（或组合物），其不具有病原体感染或致病因子的传播的风险，具有高安全性。 材料（或组合物）包含至少具有由式-Pro-Y-Gly-（其中Y表示Pro或Hyp）表示的氨基酸序列的胶原样合成多肽。 多肽可以在波长为220-230nm的范围内显示出正的棉花效应，在圆二色谱中在195至205nm的波长范围内显示出负的棉花效应。 多肽的至少一部分可能能够形成三重螺旋结构。 多肽可以用胶原酶降解。
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公开(公告)号：US07262275B2
公开(公告)日：2007-08-28
申请号：US10372994
申请日：2003-02-26
CPC分类号： C07K7/08 , C07K14/001 , C07K14/78
摘要： The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a; (2) [—(OC—(CH2)m—CO)q-(Z)r-]b; and (3) [—HN—R—NH—]c, wherein “m” is 1-18 , “p” and “q” are identical or different, and each is 0 or 1 , “Y” is Pro or Hyp, and “n”1-20 ; “Z” is a peptide chain comprising 1-10 amino acids, “r”1-20 , and “R” is a linear or branched alkylene group; the molar ratio of “a” to “b”[a/b] is 100/0 to 30/70 ; when p=1 and q=0, c=a, when p=0 and q=1, c=b, when p=1 and q=1, c=a+b, and when p=0 and q=0, c=0; and the polypeptide shows a peak of molecular weight in a range from 1×104 to 100×104 in the molecular weight distribution.
摘要翻译： 本发明提供了可用作生物材料并且不感染的多肽。 多肽包含式（1）的肽单元和任选的一个或多个式（2）至（3）的单元：（1）[ - （OC-（CH 2） m-CO）p - （Pro-Y-Gly）n - - - - - - - - （2）[ - （OC-（CH 2）m -CO）q - （Z） - ] 和（3）[-HN-R-NH-] C，其中“m”为1-18，“p”和“q”相同或不同，并且各自为0或1， “Y”是Pro或Hyp，“n”1-20; “Z”是包含1-10个氨基酸“r”1-20的肽链，“R”是直链或支链亚烷基; “a”与“b”[a / b]的摩尔比为100/0至30/70; 当p = 1和q = 0时，c = a，当p = 0和q = 1时，c = b，当p = 1和q = 1时，c = a + b，当p = 0且q = 0时 ，c = 0; 并且多肽在分子量分布中显示分子量在1×10 4至100×10 4范围内的峰。
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公开(公告)号：US07217680B2
公开(公告)日：2007-05-15
申请号：US11032072
申请日：2005-01-11
申请人： Isao Teshigahara , Hisao Kinoshita
发明人： Isao Teshigahara , Hisao Kinoshita
IPC分类号： B01J23/00 , C07C51/235
CPC分类号： B01J23/8885 , B01J23/002 , B01J23/8877 , B01J27/228 , B01J35/002 , B01J37/0009 , B01J37/0045 , B01J37/0236 , B01J2523/00 , C07C51/252 , C07C57/04 , B01J2523/17 , B01J2523/41 , B01J2523/53 , B01J2523/55 , B01J2523/56 , B01J2523/68
摘要： A method for producing a composite oxide catalyst for gas phase catalytic oxidation of an unsaturated aldehyde with a molecular oxygen-containing gas to produce the corresponding unsaturated carboxylic acid in good yield, is presented. A method for producing a composite oxide catalyst, which is a method for producing a composite oxide catalyst having the following formula (I), characterized in that Sb2O3 of isometric system is used as at least a part of an antimony-supplying source compound: Mo12XaVbSbcCudSieCfOg (I) (wherein the respective components and variables have the following meanings: X is at least one element selected from the group consisting of Nb and W; a, b, c, d, e, f and g represent atomic ratios of the respective elements, and against 12 of molybdenum atom, 0
摘要翻译： 提出了一种用含有分子氧的气体制备不饱和醛的气相催化氧化复合氧化物催化剂的方法，以产生相当的不饱和羧酸，产率良好。 一种复合氧化物催化剂的制造方法，其为具有下述式（I）的复合氧化物催化剂的制造方法，其特征在于，将Sb 2 O 3 O 3 系统用作锑供应源化合物的至少一部分：<？in-line-formula description =“In-line Formulas”end =“lead”？> Mo 12
>>>>> SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>（其中各个组件和变量具有以下含义：X在 选自Nb和W中的至少一种元素; a，b，c，d，e，f和g表示各元素的原子比，对于钼原子的12，0 -
公开(公告)号：US20050261521A1
公开(公告)日：2005-11-24
申请号：US11032072
申请日：2005-01-11
申请人： Isao Teshigahara , Hisao Kinoshita
发明人： Isao Teshigahara , Hisao Kinoshita
IPC分类号： B01J23/88 , B01J27/228 , B01J37/00 , C07B61/00 , C07C51/16 , C07C51/235 , C07C51/25 , C07C57/055
CPC分类号： B01J23/8885 , B01J23/002 , B01J23/8877 , B01J27/228 , B01J35/002 , B01J37/0009 , B01J37/0045 , B01J37/0236 , B01J2523/00 , C07C51/252 , C07C57/04 , B01J2523/17 , B01J2523/41 , B01J2523/53 , B01J2523/55 , B01J2523/56 , B01J2523/68
摘要： A method for producing a composite oxide catalyst for gas phase catalytic oxidation of an unsaturated aldehyde with a molecular oxygen-containing gas to produce the corresponding unsaturated carboxylic acid in good yield, is presented. A method for producing a composite oxide catalyst, which is a method for producing a composite oxide catalyst having the following formula (I), characterized in that Sb2O3 of isometric system is used as at least a part of an antimony-supplying source compound: Mo12XaVbSbcCudSieCfOg (I) (wherein the respective components and variables have the following meanings: X is at least one element selected from the group consisting of Nb and W; a, b, c, d, e, f and g represent atomic ratios of the respective elements, and against 12 of molybdenum atom, 0
摘要翻译： 提出了一种用含有分子氧的气体制备不饱和醛的气相催化氧化复合氧化物催化剂的方法，以产生相当的不饱和羧酸，产率良好。 一种复合氧化物催化剂的制造方法，其为具有下述式（I）的复合氧化物催化剂的制造方法，其特征在于，将Sb 2 O 3 O 3 系统用作锑供应源化合物的至少一部分：<？in-line-formula description =“In-line Formulas”end =“lead”？> Mo 12
>>>>> SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB SUB （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>（其中各个组件和变量具有以下含义：X在 选自Nb和W中的至少一种元素; a，b，c，d，e，f和g表示各元素的原子比，对于钼原子的12，0
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