公开(公告)号：US20060067910A1

公开(公告)日：2006-03-30

申请号：US10532670

申请日：2003-10-29

申请人： Masayuki Kitagawa ,  Kazuya Okamoto

发明人： Masayuki Kitagawa ,  Kazuya Okamoto

IPC分类号： A61K31/785 ,  C08G63/91

CPC分类号： C07D491/22 ,  A61K31/4745 ,  A61K47/60 ,  A61K47/645

摘要： It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.

公开(公告)号：US07495099B2

公开(公告)日：2009-02-24

申请号：US10532670

申请日：2003-10-29

申请人： Masayuki Kitagawa ,  Kazuya Okamoto

发明人： Masayuki Kitagawa ,  Kazuya Okamoto

IPC分类号： C07D491/22 ,  A61K31/4745

CPC分类号： C07D491/22 ,  A61K31/4745 ,  A61K47/60 ,  A61K47/645

摘要： It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.

摘要翻译： 旨在提供治疗效果优异且适合癌症化疗的喜树碱水溶性衍生物。 即，通过将聚乙二醇 - 多元羧酸聚合物的羧酸基团与苯酚羟丁酸的酚羟基进行酯键化而获得的缓释性优异的营then素的水溶性高分子量衍生物。

公开(公告)号：US06820166B2

公开(公告)日：2004-11-16

申请号：US09757314

申请日：2001-01-09

申请人： Masayuki Kitagawa

发明人： Masayuki Kitagawa

IPC分类号： G06F1300

CPC分类号： G06F13/4068

摘要： The present invention relates to a method and system for selecting one of the two functions. The system in accordance with one embodiment of the invention includes a first entity that has a host function and a device function, and a second entity that has at least one of the two functions. The system further includes a detector and a selecting mechanism. The detector detects the second entity when the first entity is connected to the second entity. The selecting mechanism responds to an output of the detector and selects one out of the host and device functions of the first entity.

摘要翻译： 本发明涉及一种用于选择两个功能之一的方法和系统。 根据本发明的一个实施例的系统包括具有主机功能和设备功能的第一实体以及具有两个功能中的至少一个功能的第二实体。 该系统还包括检测器和选择机构。 当第一实体连接到第二实体时，检测器检测第二实体。 选择机制响应于检测器的输出，并从第一实体的主机和设备功能中选出一个。

公开(公告)号：US5179084A

公开(公告)日：1993-01-12

申请号：US504393

申请日：1990-04-04

申请人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Katsutoshi Takahashi ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

发明人： Seiichi Saito ,  Shigeru Hasegawa ,  Masayuki Kitagawa ,  Nobuyoshi Shimada ,  Katsutoshi Takahashi ,  Jun-ichi Seki ,  Hiroo Hoshino ,  Yukihiro Nishiyama ,  Kenichi Matsubara ,  Takemitsu Nagahata

IPC分类号： C07H19/02

CPC分类号： C07H19/02

摘要： The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.

公开(公告)号：US20120116051A1

公开(公告)日：2012-05-10

申请号：US13319175

申请日：2010-05-12

申请人： Masayuki Kitagawa ,  Chieko Seno ,  Keiko Ebara ,  Kazutoshi Takashio

发明人： Masayuki Kitagawa ,  Chieko Seno ,  Keiko Ebara ,  Kazutoshi Takashio

IPC分类号： C08H1/00 ,  A61P9/10 ,  A61P17/14 ,  A61P29/00 ,  A61P35/00

CPC分类号： C08G69/10 ,  A61K31/167 ,  A61K31/19 ,  A61K31/195 ,  A61K31/337 ,  A61K31/365 ,  A61K31/4745 ,  A61K31/52 ,  A61K31/573 ,  A61K31/704 ,  A61K31/7052 ,  A61K31/7068 ,  A61K47/60 ,  A61K47/645 ,  C08G69/40 ,  C08G69/48

摘要： A polymer conjugate of a physiologically active substance, which enables drug release independent of a biological enzyme and can be expected to have a high therapeutic effect, is demanded.Provided is a polymer conjugate of a physiologically active substance, comprising a block copolymer of a polyethylene glycol moiety and a polymer having two or more carboxy groups, in which a substituent represented by general formula (I) or general formula (II) is linked to at least one of the side-chain carboxy groups of the block copolymer via an amide bond [in the formula, R8 and R9 each independently are hydrogen atom or (C1-C6)alkyl which may have a substituent, R10 is hydrogen atom, (C1-C40)alkyl which may have a substituent, (C1-C40) aralkyl group which may have a substituent, an aromatic group which may have a substituent, an amino acid residue having a protected carboxy group, or a sugar residue which may have a substituent, CX—CY represents CH—CH or C═C (double bond), and A represents a residue obtained by removing, from a physiologically active substance having one or more hydroxy groups, one of the one or more hydroxy groups].

摘要翻译： 需要生物活性物质的聚合物缀合物，其使药物释放与生物酶无关并且可以预期具有高治疗效果。 提供了一种生理活性物质的聚合物缀合物，其包含聚乙二醇部分和具有两个或更多个羧基的聚合物的嵌段共聚物，其中由通式（I）或通式（II）表示的取代基与 嵌段共聚物中的至少一个侧链羧基通过酰胺键[在式中，R8和R9各自独立地为氢原子或可具有取代基的（C1-C6）烷基，R10为氢原子（ 可以具有取代基的C 1 -C 40的烷基，可以具有取代基的（C 1〜C 40）芳烷基，可以具有取代基的芳香族基，具有被保护的羧基的氨基酸残基， 取代基，CX-CY表示CH-CH或C = C（双键），A表示通过从具有一个或多个羟基的生理活性物质除去一个或多个羟基之一而获得的残基]。

公开(公告)号：US20100234537A1

公开(公告)日：2010-09-16

申请号：US12225230

申请日：2007-03-22

申请人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Takeshi Onda

发明人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Takeshi Onda

IPC分类号： C08G69/48

CPC分类号： C08G65/33324 ,  A61K31/337 ,  A61K47/60 ,  A61K47/645 ,  C08G65/329 ,  C08G69/10 ,  C08G69/40 ,  C08G69/48 ,  C08L2203/02

摘要： [Problems] To provide a novel taxane derivative which can release the medicinal substance in a bioenzyme-independent manner, is expected to have an effective therapeutic efficacy, and has a water-solubility.[Means for Solving Problems] Disclosed is a polymer conjugate of a taxane, which comprises a polymer having a polyethylene glycol moiety and two or more succinic acid monoamide moieties and a taxane, wherein a carboxylate group in the polymer and an alcoholic hydroxyl group in the taxane are bound to each other via an ester bonding.

摘要翻译： [问题]为了提供能够以不依赖生物酶的方式释放药物的新型紫杉烷衍生物，预期具有有效的治疗功效，并且具有水溶性。 解决问题的手段公开了紫杉烷的聚合物缀合物，其包含具有聚乙二醇部分和两个或多个琥珀酸单酰胺部分的聚合物和紫杉烷，其中聚合物中的羧酸酯基团和 紫杉烷通过酯键相互结合。

公开(公告)号：US4841076A

公开(公告)日：1989-06-20

申请号：US58105

申请日：1987-06-04

申请人： Masayuki Kitagawa ,  Makoto Tanaka

发明人： Masayuki Kitagawa ,  Makoto Tanaka

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/40 ,  A61K31/41 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P7/10 ,  A61P9/12 ,  A61P19/06 ,  C07D311/22 ,  C07D311/26 ,  C07D311/28 ,  C07D311/30 ,  C07D311/32 ,  C07D311/34 ,  C07D311/36 ,  C07D311/38 ,  C07D311/62 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D311/22 ,  C07D311/36 ,  C07D311/38

摘要： A benzopyran derivative represented by formula ##STR1## wherein: R.sub.1 and R.sub.2 each represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted cyclic alkyl group, a mono- or di-lower alkylamino group, a substituted or unsubsituted cyclic amino group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group;Y.sub.1 and Y.sub.2 each represents a hydrogen atom, a lower alkyl group, a halogen atom or a trihalomethyl group;Z represents a caroxyl group, a lower alkoxy-carbonyl group, a tetrazolyl group, a hydroxyl group or --CONR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 each represents a hydrogen atom or a lower alkyl group;n represents an integer of from 1 to 6; andthe bond between the 2- and 3-positions represents a single bond or a double bond;provided that a combination wherein Y.sub.1, Y.sub.2, and R.sub.2 each represents a hydrogen atom, R.sub.1 represents a phenyl group, n represents 1, Z represents a carboxyl group or an alkoxycarbonyl group, and the bond represents a double bond, and a combination wherein Y.sub.1, Y.sub.2, and R.sub.1 each represents a hydrogen atom, R.sub.2 represents a phenyl group, n represents 1, Z represents a carboxyl group or an alkoxy-carbonyl group, and the bond represents a double bond are excluded, and pharmaceutically acceptable salts thereof are disclosed. These compounds have uricosuric activity, diuretic activity and antihypertensive activity, and are useful as pharmaceuticals.

摘要翻译： 由式表示的苯并吡喃衍生物其中：R1和R2各自表示氢原子，低级烷基，取代或未取代的环状烷基，一或二低级烷基氨基，取代或未取代的环状氨基 取代或未取代的芳基或取代或未取代的芳烷基; Y1和Y2各自表示氢原子，低级烷基，卤素原子或三卤代甲基; Z表示羧酸基，低级烷氧基 - 羰基，四唑基，羟基或-CONR 3 R 4，其中R 3和R 4各自表示氢原子或低级烷基; n表示1〜6的整数， 并且2-和3-位之间的键表示单键或双键; 条件是其中Y1，Y2和R2各自表示氢原子，R1表示苯基，n表示1，Z表示羧基或烷氧基羰基，键表示双键的组合，其中Y1 ，Y2和R1各自表示氢原子，R2表示苯基，n表示1，Z表示羧基或烷氧基 - 羰基，并且该键代表双键，并且其公开的药学上可接受的盐被公开 。 这些化合物具有尿酸活性，利尿活性和抗高血压活性，并且可用作药物。

公开(公告)号：US20130330090A1

公开(公告)日：2013-12-12

申请号：US14001075

申请日：2012-02-24

申请人： Akira Obika ,  Masayuki Kitagawa

发明人： Akira Obika ,  Masayuki Kitagawa

IPC分类号： H04B10/50

CPC分类号： H04B10/503 ,  H01S5/005 ,  H01S5/02228 ,  H01S5/0228 ,  H01S5/02296 ,  H01S5/0683 ,  H01S5/183

摘要： A communication module according to the present invention includes a substrate, a laser element and a light receiving element provided on a front surface of the substrate and separating from each other, a transparent resin package collectively sealing the laser element and the light receiving element, and a diffusion unit provided to be opposed to a light emitting surface of the laser element at a prescribed distance for diffusing a laser beam emitted by the laser element, while the distance T between the laser element and the light receiving element satisfies the following formula (1): T≧t1·tan θ+(t1+t2)·tan θ′ . . . (1) (in the formula (1), t1 represents the distance between the light emitting surface of the laser element and the diffusion unit, θ represents the maximum angle of emission of the laser element, t2 represents the difference between the height from the front surface of the substrate up to the light emitting surface and the height up to alight receiving surface of the light receiving element, and θ′ represents the maximum diffusion angle of the diffusion unit.)

摘要翻译： 根据本发明的通信模块包括：基板，激光元件和设置在基板的前表面上的光接收元件，彼此分离，一体地密封激光元件和光接收元件的透明树脂封装;以及 扩散单元，设置成与激光元件的发光面相对规定距离，用于扩散由激光元件发射的激光束，而激光元件和光接收元件之间的距离T满足下式（1 ）：T> = t1·tanθ+（t1 + t2）·tanθ'。 。 。 （1）（式（1）中，t1表示激光元件的发光面与扩散单元之间的距离，θ表示激光元件的最大发射角，t2表示与 衬底的前表面直到发光表面和高度接近光接收元件的接收表面，θ'表示扩散单元的最大扩散角。）

公开(公告)号：US20100004403A1

公开(公告)日：2010-01-07

申请号：US12309061

申请日：2007-07-13

申请人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Akira Masuda ,  Kazutoshi Takashio

发明人： Masayuki Kitagawa ,  Keizou Ishikawa ,  Akira Masuda ,  Kazutoshi Takashio

IPC分类号： C08L71/02

CPC分类号： C08G73/1092 ,  A61K47/60 ,  A61K47/645

摘要： A novel derivative of combretastatins which has water solubility and is capable of releasing the drug independent of biological enzymes likely to cause individual differences and whose effective therapeutic effect can be expected has been demanded. A high-molecular weight conjugate of combretastatins, characterized by having a structure in which a hydroxyl group of a combretastatin is linked via an ester bond to a carboxylic acid group of the polymer moiety in a block copolymer of a polyethylene glycol moiety with the polymer moiety having two or more carboxylic acid groups such as polyaspartic acid or polyglutamic acid is provided.

摘要翻译： 已经要求具有水溶性并且能够释放药物的新型衍生物，其独立于可能导致个体差异的生物酶，并且可以预期其有效的治疗效果。 考布斯他汀的高分子量缀合物，其特征在于具有以下结构：考布他汀的羟基通过酯键与聚乙烯部分与聚合物部分的嵌段共聚物中的聚合物部分的羧酸基团连接 提供具有两个或更多个羧酸基团，例如聚天冬氨酸或聚谷氨酸。

公开(公告)号：US06708231B1

公开(公告)日：2004-03-16

申请号：US09372485

申请日：1999-08-12

申请人： Masayuki Kitagawa

发明人： Masayuki Kitagawa

IPC分类号： G06F1136

CPC分类号： G06F8/65

摘要： The present invention provides systems and methods for performing a firmware update. In one embodiment, a peripheral reset signal is masked in response to a peripheral firmware update command. The firmware update is loaded into a peripheral's nonvolatile memory while the reset signal is masked.

摘要翻译： 本发明提供了用于执行固件更新的系统和方法。 在一个实施例中，响应于外围固件更新命令掩蔽外围复位信号。 当复位信号被屏蔽时，固件更新被加载到外设的非易失性存储器中。