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16 条记录 (耗时 0.029 秒)

    Quinoline-N-oxide derivative and pharmaceutical composition
    2.
    发明授权
    Quinoline-N-oxide derivative and pharmaceutical composition 失效
    喹啉-N-氧化物衍生物和药物组合物

    公开(公告)号：US4657916A

    公开(公告)日：1987-04-14

    申请号：US772693

    申请日：1985-09-05

    申请人： Masayuki Teranishi ,  Koji Suzuki ,  Hiroshi Kase ,  Shigeto Kitamura ,  Katsuichi Shuto ,  Kenji Omori

    发明人： Masayuki Teranishi ,  Koji Suzuki ,  Hiroshi Kase ,  Shigeto Kitamura ,  Katsuichi Shuto ,  Kenji Omori

    IPC分类号： A61K31/47 ,  A61P43/00 ,  C07D215/60 ,  C07D405/12 ,  C07F7/18

    CPC分类号： C07D405/12 ,  C07D215/60

    摘要： A quinoline-N-oxide derivative represented by the formula: ##STR1## wherein X is hydroxy, lower alkoxy, lower alkylthio, unsubstituted or substituted aralkyloxy, or unsubstituted or substituted aralkylthio; Y is a hydrogen atom or halogen atom; R.sub.1 is alkylene or alkenylene having 3 to 15 carbon atom; Z is hydroxymethyl, lower alkoxymethyl, unsubstituted or substituted aryloxymethyl, tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, unsubstituted or substituted arylsulfonyloxymethyl, lower alkylthiomethyl, unsubstituted or substituted arylthiomethyl, lower alkylsulfinylmethyl, unsubstituted or substituted arylsulfinylmethyl, lower alkylsulfonylmethyl, unsubstituted or substituted arylsulfonylmethyl, aminomethyl, --CH.sub.2 NHR.sub.2 (wherein R.sub.2 is lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 NR.sub.3 R.sub.4 (wherein R.sub.3 and R.sub.4 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 N.sup.+ R.sub.5 R.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl, where the counterion is an anion of acid or a hydroxyl ion), --COR.sub.8 (wherein R.sub.8 is a hydrogen atom, lower alkyl or hydroxy), --CH(OR.sub.9).sub.2 (wherein R.sub.9 is lower alkyl), iminomethyl, hydroxyiminomethyl, or a halogen atom and its salts, can very strongly inhibit the lipoxygenase and considerably suppress production and release of its metabolites, and thus are useful as preventive and healing agents for the diseases caused by the lipoxygenase metabolites.

    摘要翻译： 由下式表示的喹啉-N-氧化物衍生物：其中X为羟基，低级烷氧基，低级烷硫基，未取代或取代的芳烷氧基，或未取代或取代的芳烷硫基; Y是氢原子或卤素原子; R1是具有3至15个碳原子的亚烷基或亚烯基; Z是羟甲基，低级烷氧基甲基，未取代或取代的芳氧基甲基，四氢吡喃氧基甲基，四氢呋喃氧基甲基，未取代或取代的芳基磺酰氧基甲基，低级烷硫基甲基，未取代或取代的芳基硫代甲基，低级烷基亚磺酰基甲基，未取代或取代的芳基亚磺酰基甲基，低级烷基磺酰基甲基，未取代或取代的芳基磺酰基甲基，氨基甲基，-CH2NHR2（ 其中R 2是低级烷基，未取代或取代的芳烷基或未取代或取代的芳基），-CH 2 NR 3 R 4（其中R 3和R 4是低级烷基，未取代或取代的芳烷基，或未取代或取代的芳基），-CH 2 N + R 5 R 6 R 7（其中R 5，R 6 ，R 7为低级烷基，未取代或取代的芳烷基或未取代或取代的芳基，其中抗衡离子为酸或羟基离子的阴离子），-COR8（其中R8为氢原子，低级烷基或羟基），-CH （OR 9）2（其中R 9为低级烷基），亚氨基甲基，羟基亚氨基甲基或卤素 原子及其盐可以非常强烈地抑制脂氧合酶，并显着抑制其代谢物的产生和释放，因此可用作由脂氧合酶代谢物引起的疾病的预防和治疗剂。

    Treating convulsions with dihydrouracil derivatives
    4.
    发明授权
    Treating convulsions with dihydrouracil derivatives 失效
    用二氢尿嘧啶衍生物治疗惊厥

    公开(公告)号：US4588729A

    公开(公告)日：1986-05-13

    申请号：US734607

    申请日：1985-05-16

    申请人： Masayuki Teranishi ,  Chikara Murakata ,  Ikuo Matsukuma ,  Katsuichi Shuto ,  Shunji Ichikawa

    发明人： Masayuki Teranishi ,  Chikara Murakata ,  Ikuo Matsukuma ,  Katsuichi Shuto ,  Shunji Ichikawa

    IPC分类号： A61K31/505 ,  A61P25/08 ,  C07D239/22 ,  A61K31/52

    CPC分类号： C07D239/22 ,  A61K31/505

    摘要： Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.

    摘要翻译： 提供的是抗惊厥组合物，其包含有效量的由下式表示的二氢尿嘧啶衍生物：其中A和B之一为（其中Y1，Y2和Y3为氢原子，低级烷基，卤素原子 硝基，氨基，羧基，低级烷氧基羰基或三氟甲基），萘基或二苯基甲基，另一个是氢原子，低级烷基，低级链烯基，环戊基，环己基 基团或（其中Z1，Z2和Z3是氢原子，低级烷基，卤素原子或三氟甲基），R1，R2和R3是氢原子或低级烷基，X是氧原子或硫原子 ]和至少一种药学上可接受的载体。

    Hypotensive piperidine derivatives
    7.
    发明授权
    Hypotensive piperidine derivatives 失效
    低血压哌啶衍生物

    公开(公告)号：US4410528A

    公开(公告)日：1983-10-18

    申请号：US264810

    申请日：1981-05-18

    申请人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    发明人： Masayuki Teranishi ,  Hiroyuki Obase ,  Nobuhiro Nakamizo ,  Kazuhiro Kubo ,  Yutaka Kasuya

    IPC分类号： C07D211/58 ,  A61K31/505 ,  C07D401/04

    CPC分类号： C07D211/58

    摘要： A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.

    摘要翻译： 由下式表示的新的哌啶衍生物：其中X是氧，硫，羰基，羟基亚甲基或亚甲基; R1是具有或不具有低级烷基取代基的具有1-4个碳原子的直链亚烷基; （A）m和R 2通常是取代基; （1）其中当p为0时，B为-N = N-，，当p为1时，B为 （3）其中（R3）n是通常使用的取代基，具有降血压作用。

    Flame retardant for halogen-containing vinyl resins
    10.
    发明授权
    Flame retardant for halogen-containing vinyl resins 失效
    含卤乙烯基树脂的阻燃剂

    公开(公告)号：US5190700A

    公开(公告)日：1993-03-02

    申请号：US574606

    申请日：1990-08-29

    申请人： Yoshitane Watanabe ,  Keitaro Suzuki ,  Kouji Shishido ,  Masayuki Teranishi ,  Masuo Shindo

    发明人： Yoshitane Watanabe ,  Keitaro Suzuki ,  Kouji Shishido ,  Masayuki Teranishi ,  Masuo Shindo

    IPC分类号： C08K3/16 ,  C08K3/22 ,  C08K13/02

    CPC分类号： C08K3/2279 ,  C08K13/02 ,  C08K3/16

    摘要： The present invention provides a power flame retardant for a halogen-containing vinyl resin, which comprises the following Components A, B and C. (A) 5 to 30 parts by weight of at least one of alkali metal compound of lithium, sodium and potassium calculated as the formula M.sub.2 O where M is an alkali metal; (B) 0.2 to 10 parts by weight of a perchloric acid radical in the form of the acid or a salt or amine thereof, calculated as perchloric acid radical; and (C) 1 to 50 parts by weight of a hydrophobic dispersing agent having a boiling point or a decomposition temperature of 200.degree. C. or higher. All the parts by weight are based on 100 parts by weight of antimony pentoxide (Sb.sub.2 O.sub.5). The flame retardant of the present invention does not impair transparency of the halogen-containing vinyl resin, and also does not worsen various physical properties such as thermal stability and weathering resistance. The invention also provides (1) flame retardant halogen containing resins and (2) a process for preparing the powdered flame retardant.

    摘要翻译： 本发明提供含卤乙烯基树脂的电力阻燃剂，其包含以下组分A，B和C.（A）5至30重量份的锂，钠和钾的碱金属化合物 按公式M2O计算，其中M为碱金属; （B）0.2至10重量份以酸或其盐或胺形式的高氯酸基团，其计为高氯酸根; 和（C）1〜50重量份的沸点或分解温度为200℃以上的疏水性分散剂。 所有重量份均基于100重量份的五氧化二锑（Sb 2 O 5）。 本发明的阻燃剂不会损害含卤乙烯基树脂的透明性，也不会使各种物理性质如热稳定性和耐候性恶化。 本发明还提供（1）阻燃卤素树脂和（2）制备阻燃剂的方法。