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公开(公告)号：US12097307B2
公开(公告)日：2024-09-24
申请号：US17377124
申请日：2021-07-15
Inventor： Arturo Vegas , Joshua C. Doloff , Omid Veiseh , Minglin Ma , Robert S. Langer , Daniel G. Anderson
IPC: A61K9/50 , A61K9/00 , A61K9/48 , A61K35/39 , A61K47/36 , A61L29/08 , A61L31/10 , A61L33/08 , C07D487/04 , C08B37/00 , C12N5/00 , C12N5/071
CPC classification number: A61L29/085 , A61K9/0024 , A61K9/4816 , A61K9/5036 , A61K35/39 , A61K47/36 , A61L31/10 , A61L33/08 , C07D487/04 , C08B37/0084 , C12N5/0012 , C12N5/0677
Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
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公开(公告)号：US20240150413A1
公开(公告)日：2024-05-09
申请号：US18549951
申请日：2022-03-11
Applicant: Massachusetts Institute of Technology
Inventor： Alexi G. Choueiri , Yong Qian , Bowen Li , Robert S. Langer , Daniel G. Anderson , Edward S. Boyden
IPC: C07K14/005 , A61K38/16 , A61K38/46 , A61P31/14 , C12N9/22
CPC classification number: C07K14/005 , A61K38/162 , A61K38/465 , A61P31/14 , C12N9/22 , C07K2319/735 , C12N2770/20022 , C12N2770/20033
Abstract: In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.
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公开(公告)号：US20230130084A1
公开(公告)日：2023-04-27
申请号：US17749795
申请日：2022-05-20
Inventor： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
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公开(公告)号：US11337930B2
公开(公告)日：2022-05-24
申请号：US17080355
申请日：2020-10-26
Inventor： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
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公开(公告)号：US20220031913A1
公开(公告)日：2022-02-03
申请号：US17377124
申请日：2021-07-15
Inventor： Arturo Vegas , Joshua C. Doloff , Omid Veiseh , Minglin Ma , Robert S. Langer , Daniel G. Anderson
IPC: A61L29/08 , A61K47/36 , A61K9/48 , A61K35/39 , C08B37/00 , A61K9/00 , A61K9/50 , A61L31/10 , A61L33/08 , C07D487/04 , C12N5/00 , C12N5/071
Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
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Patent Agency Ranking
公开(公告)号：US20210371494A1
公开(公告)日：2021-12-02
申请号：US17384460
申请日：2021-07-23
Inventor： Alexander Wesselhoeft , Daniel G. Anderson , Shinichiro Fuse , Brian Goodman , Allen T. Horhota , Raffaella Squilloni
IPC: C07K14/725 , A61K35/17 , C07K16/28 , A61K9/51
Abstract: Circular RNA and transfer vehicles, along with related compositions and methods are described herein. In some embodiments, the inventive circular RNA comprises group I intron fragments, spacers, an IRES, duplex forming regions, and an expression sequence. In some embodiments, the expression sequence encodes a chimeric antigen receptor (CAR). In some embodiments, circular RNA of the invention has improved expression, functional stability, immunogenicity, ease of manufacturing, and/or half-life when compared to linear RNA. In some embodiments, inventive methods and constructs result in improved circularization efficiency, splicing efficiency, and/or purity when compared to existing RNA circularization approaches.
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公开(公告)号：US10786446B2
公开(公告)日：2020-09-29
申请号：US16200334
申请日：2018-11-26
Inventor： Minglin Ma , Daniel G. Anderson , Robert S. Langer , Omid Veiseh , Joshua Charles Doloff , Delai Chen , Christian J. Kastrup , Arturo Jose Vegas
Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
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公开(公告)号：US10730983B2
公开(公告)日：2020-08-04
申请号：US15621391
申请日：2017-06-13
Inventor： Omid Veiseh , Volkan Yesilyurt , Arturo Vegas , Joshua Doloff , Daniel G. Anderson , Robert S. Langer
IPC: C08F230/02 , A61L29/08 , A61L27/26 , A61L27/52 , A61L27/34 , A61L27/38 , A61L27/54 , A61K35/12 , A61K9/50 , A61L29/04 , A61L31/10 , A61L31/04 , A61L27/56 , A61L29/16 , A61L31/16 , C08F220/38 , C08F30/02 , C08F20/38 , A61B5/145
Abstract: Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.
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公开(公告)号：US10426735B2
公开(公告)日：2019-10-01
申请号：US14817084
申请日：2015-08-03
Inventor： Arturo J. Vegas , Joshua C. Doloff , Omid Veiseh , Minglin Ma , Robert S. Langer , Daniel G. Anderson
IPC: A61K35/39 , A61K9/50 , C08B37/00 , C12N5/00 , C12N5/071 , A61K9/00 , A61L29/08 , A61L31/10 , A61L33/08
Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
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公开(公告)号：US20190144845A9
公开(公告)日：2019-05-16
申请号：US16029273
申请日：2018-07-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Hao Yin , Wen Xue , Daniel G. Anderson , Joseph R. Dorkin , Tyler E. Jacks
Abstract: The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.
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