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公开(公告)号：US20170311894A1
公开(公告)日：2017-11-02
申请号：US15498268
申请日：2017-04-26
Inventor： Phillip Nadeau , Dina El-Damak , Dean Glettig , Yong Lin Kong , Niclas Roxhed , Robert Langer , Anantha P. Chandrakasan , Carlo Giovanni Traverso
IPC: A61B5/00 , A61B5/01 , A61B5/024 , A61B1/04 , H01M6/04 , A61B5/03 , H01M4/06 , A61B5/145 , A61B5/08 , A61B5/07 , H01M6/34 , H01M4/38
CPC classification number: A61B5/6861 , A61B1/00027 , A61B1/041 , A61B5/01 , A61B5/024 , A61B5/036 , A61B5/073 , A61B5/08 , A61B5/14503 , A61B5/14539 , A61B2503/40 , A61B2560/0214 , H01M2/1022 , H01M4/06 , H01M4/38 , H01M6/045 , H01M6/34 , H01M2220/30 , H01M2300/0005
Abstract: Aspects disclosed in the detailed description include an ingestible power harvesting device and related applications. An ingestible power harvesting device includes a cathode electrode and an anode electrode that can catalyze a power generating reaction to generate a direct current (DC) power when surrounded by an acidic electrolyte. The cathode electrode and the anode electrode are coupled to an encapsulated electronic device that includes power harvesting circuitry configured to harvest the DC power and output a DC supply voltage for a prolonged period. In examples discussed herein, the prolonged period is at least five days. The DC supply voltage powers an electronic circuit in the encapsulated electronic device to support a defined in vivo operation (e.g., controlled drug delivery, in vivo vital signs monitoring, etc.). As such, the ingestible power harvesting device can operate in vivo for the prolonged period without requiring an embedded conventional battery.
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公开(公告)号：US20220378363A1
公开(公告)日：2022-12-01
申请号：US17730075
申请日：2022-04-26
Applicant: Massachusetts Institute of Technology , Trustees of Boston University , The Brigham and Women's Hospital, Inc.
Inventor： Timothy Kuan-Ta Lu , Rabia Tugce Yazicigil Kirby , Carlo Giovanni Traverso , Jenna Ahn , Maria Eugenia Inda , Miguel Jimenez , Qijun Liu , Phillip Nadeau , Christoph Winfried Johannes Steiger , Adam Wentworth
IPC: A61B5/00 , C12Q1/6897 , A61B5/145 , A61B5/1459
Abstract: Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 μL of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication. The wireless detection of short-lived, disease-associated molecules may support earlier diagnosis of disease than is currently possible, more accurate tracking of disease progression, and more timely communication between patient and their care team supporting remote personalized care.
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公开(公告)号：US20190313942A1
公开(公告)日：2019-10-17
申请号：US15955080
申请日：2018-04-17
Applicant: Massachusetts Institute of Technology
Inventor： TIMOTHY KUAN-TA LU , Mark K. Mimee , Phillip Nadeau , Anantha P. Chandrakasan
Abstract: Disclosed herein are novel devices comprising small, ultra-low power microelectronic components. In some instances, the microelectronic components is combined with a biosensor component that enables in situ detection of biomolecules. Also disclosed herein are methods of detecting signal analytes and methods of monitoring the health of a patient using these novel devices.
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