公开(公告)号：US20220378363A1

公开(公告)日：2022-12-01

申请号：US17730075

申请日：2022-04-26

申请人： Massachusetts Institute of Technology ,  Trustees of Boston University ,  The Brigham and Women's Hospital, Inc.

发明人： Timothy Kuan-Ta Lu ,  Rabia Tugce Yazicigil Kirby ,  Carlo Giovanni Traverso ,  Jenna Ahn ,  Maria Eugenia Inda ,  Miguel Jimenez ,  Qijun Liu ,  Phillip Nadeau ,  Christoph Winfried Johannes Steiger ,  Adam Wentworth

IPC分类号： A61B5/00 ,  C12Q1/6897 ,  A61B5/145 ,  A61B5/1459

摘要： Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 μL of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication. The wireless detection of short-lived, disease-associated molecules may support earlier diagnosis of disease than is currently possible, more accurate tracking of disease progression, and more timely communication between patient and their care team supporting remote personalized care.

公开(公告)号：US12059562B2

公开(公告)日：2024-08-13

申请号：US17512156

申请日：2021-10-27

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal

IPC分类号： A61N1/05 ,  A61L31/02 ,  A61N1/36 ,  A61N1/372 ,  A61M25/01

CPC分类号： A61N1/0509 ,  A61L31/022 ,  A61N1/36007 ,  A61N1/37223 ,  A61M25/0116

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one 5 or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissue 10 interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

公开(公告)号：US12016901B2

公开(公告)日：2024-06-25

申请号：US17118521

申请日：2020-12-10

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Junwei Li ,  Thomas Wang ,  Ameya R. Kirtane ,  Yunhua Shi

IPC分类号： A61K38/17 ,  A61K31/495 ,  A61K45/06 ,  A61L24/04 ,  A61L24/06 ,  A61L24/08 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  C12N9/08

CPC分类号： A61K38/1787 ,  A61K31/495 ,  A61K45/06 ,  A61L24/046 ,  A61L24/06 ,  A61L24/08 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  C12N9/0065 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/438 ,  A61L2400/04 ,  A61L2430/06 ,  A61L2430/16 ,  C12Y111/01006

摘要： The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

公开(公告)号：US20240091384A1

公开(公告)日：2024-03-21

申请号：US18325332

申请日：2023-05-30

申请人： President and Fellows of Harvard College ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  The General Hospital Corporation

发明人： Denitsa M. Milanova ,  George M. Church ,  Noah Davidsohn ,  Carl Schoellhammer ,  Robert S. Langer ,  Anna I. Mandinova ,  Carlo Giovanni Traverso

IPC分类号： A61K48/00 ,  A61K47/69 ,  A61N7/00 ,  C12N15/86

CPC分类号： A61K48/0075 ,  A61K47/6901 ,  A61N7/00 ,  C12N15/86 ,  A61K9/7023

摘要： A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

公开(公告)号：US11712421B2

公开(公告)日：2023-08-01

申请号：US16614177

申请日：2018-05-17

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158 ,  A61N1/05

CPC分类号： A61K9/4808 ,  A61B5/14503 ,  A61B5/14539 ,  A61B10/02 ,  A61J3/07 ,  A61K9/0002 ,  A61K9/0012 ,  A61K9/0021 ,  A61K9/0065 ,  A61K9/0092 ,  A61K9/4866 ,  A61K38/28 ,  A61M5/14276 ,  A61M5/158 ,  A61M5/2033 ,  A61M5/329 ,  A61M5/3295 ,  A61M31/002 ,  A61M37/0015 ,  A61N1/325 ,  A61N1/36007 ,  A61B10/0233 ,  A61B2010/0208 ,  A61M2005/14284 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2205/0238 ,  A61M2205/21 ,  A61M2210/106 ,  A61M2210/1053 ,  A61N1/0509

摘要： Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

公开(公告)号：US11648381B2

公开(公告)日：2023-05-16

申请号：US16684638

申请日：2019-11-15

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Sahab I Babaee ,  Simo Pajovic ,  Jiuyun | Shi

IPC分类号： A61M31/00 ,  A61M5/142 ,  A61L31/16

CPC分类号： A61M31/002 ,  A61L31/16 ,  A61M5/14276

摘要： Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken and/or disassemble the residence device.

公开(公告)号：US20230050912A1

公开(公告)日：2023-02-16

申请号：US17826799

申请日：2022-05-27

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61N1/36 ,  A61K9/00 ,  A61N1/32 ,  A61M5/32 ,  A61B5/145 ,  A61B10/02 ,  A61M5/20 ,  A61M31/00 ,  A61M5/142 ,  A61M5/158 ,  A61M37/00 ,  A61K38/28 ,  A61N1/05

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20220175681A1

公开(公告)日：2022-06-09

申请号：US17497849

申请日：2021-10-08

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20220151940A1

公开(公告)日：2022-05-19

申请号：US17530585

申请日：2021-11-19

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  David Dellal ,  Robert S. Langer

IPC分类号： A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158

摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20210361919A1

公开(公告)日：2021-11-25

申请号：US17055905

申请日：2019-05-17

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal ,  Christoph Winfried Johannes Steiger ,  Niclas Roxhed ,  Ester Caffarel Salvador ,  Vance Soares ,  Daniel Minahan ,  Morten Revsgaard Frederiksen

IPC分类号： A61M31/00 ,  A61M37/00

摘要： Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component h contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.