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公开(公告)号：US20190313942A1
公开(公告)日：2019-10-17
申请号：US15955080
申请日：2018-04-17
Applicant: Massachusetts Institute of Technology
Inventor： TIMOTHY KUAN-TA LU , Mark K. Mimee , Phillip Nadeau , Anantha P. Chandrakasan
Abstract: Disclosed herein are novel devices comprising small, ultra-low power microelectronic components. In some instances, the microelectronic components is combined with a biosensor component that enables in situ detection of biomolecules. Also disclosed herein are methods of detecting signal analytes and methods of monitoring the health of a patient using these novel devices.
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Patent Agency Ranking
公开(公告)号：US20180163216A1
公开(公告)日：2018-06-14
申请号：US15580859
申请日：2016-06-10
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee , Christopher Voigt , Alex C. Tucker
IPC: C12N15/74 , A61K48/00 , A61K35/741 , C12N15/90 , C12N9/12 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/67
CPC classification number: C12N15/74 , A61K35/741 , A61K48/0066 , C07K14/195 , C12N9/12 , C12N9/16 , C12N9/22 , C12N9/93 , C12N9/96 , C12N15/11 , C12N15/63 , C12N15/67 , C12N15/902 , C12N2310/14 , C12N2310/20 , C12N2800/80 , C12N2840/203
Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
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公开(公告)号：US20170145061A1
公开(公告)日：2017-05-25
申请号：US15355809
申请日：2016-11-18
Applicant: Massachusetts Institute of Technology
Inventor： TIMOTHY KUAN-TA LU , Mark K. Mimee , Juliane Ripka
CPC classification number: C07K14/195 , A61K35/74 , A61K38/164 , A61K38/2066 , A61K39/0216 , A61K2035/11 , C07K14/5428 , C07K2319/00 , C07K2319/035 , C07K2319/50 , C12N15/03 , C12N15/62 , C12N15/74
Abstract: The present disclosure provides, in some aspects, versatile intestinal protein delivery systems deploying engineered human gut commensals of the Bacteroides species to secrete heterologous, therapeutic proteins via outer membrane vesicles (OMVs).
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公开(公告)号：US11591604B2
公开(公告)日：2023-02-28
申请号：US15580859
申请日：2016-06-10
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee , Christopher Voigt , Alex C. Tucker
IPC: A61K35/741 , C12N15/74 , A61K48/00 , C12N9/12 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/67 , C12N15/90
Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
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公开(公告)号：US20210071159A1
公开(公告)日：2021-03-11
申请号：US16936881
申请日：2020-07-23
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Robert James Citorik , Mark K. Mimee
Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
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公开(公告)号：US20170058282A1
公开(公告)日：2017-03-02
申请号：US15205625
申请日：2016-07-08
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Mark K. Mimee
CPC classification number: C12N15/70 , A61K35/74 , A61K49/0013 , A61K49/0017 , A61K49/0069 , C07K14/245 , C07K14/31 , C07K14/335 , C12N15/635 , C12N15/746 , C12Q1/02 , C12Q1/6897 , G01N2800/22
Abstract: Provided herein are microorganisms engineered with heme-responsive transcription factors and genetic circuits. Also provided are methods for using engineered microorganisms to sense bleeding events and treat bleeding in vivo.
Abstract translation: 本文提供了用血红素反应转录因子和遗传回路工程化的微生物。 还提供了使用工程微生物感测出血事件和治疗体内出血的方法。
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