公开(公告)号：US20070191378A1

公开(公告)日：2007-08-16

申请号：US10568029

申请日：2004-08-13

申请人： Matthew Campbell ,  Richard Hatley ,  Jag Heer ,  Andrew Mason ,  Ivan Pinto ,  Shahzad Rahman ,  Ian Smith

发明人： Matthew Campbell ,  Richard Hatley ,  Jag Heer ,  Andrew Mason ,  Ivan Pinto ,  Shahzad Rahman ,  Ian Smith

IPC分类号： A61K31/498 ,  A61K31/47 ,  A61K31/195 ,  C07D217/12 ,  C07D215/08

CPC分类号： C07D209/18 ,  C07C233/55 ,  C07C235/24 ,  C07C235/38 ,  C07C237/22 ,  C07C2602/08 ,  C07C2602/10 ,  C07D217/12 ,  C07D217/24 ,  C07D317/60 ,  C07D333/60

摘要： Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.

摘要翻译： 式（I）的治疗活性邻氨基苯甲酸衍生物，所述衍生物的制备方法，含有该化合物的药物制剂以及该化合物在治疗中的用途，特别是用于治疗HM74A受体活化不足的疾病 所述疾病或所述受体的活化将是有益的。

公开(公告)号：US20050004119A1

公开(公告)日：2005-01-06

申请号：US10495586

申请日：2002-11-13

申请人： Alan Borthwick ,  Matthew Campbell ,  Chuen Chan ,  Henry Kelly ,  Nigel King ,  Savvas Kleanthous ,  Andrew Mason ,  Stefan Senger ,  Paul Smith ,  Nigel Watson ,  Robert Young

发明人： Alan Borthwick ,  Matthew Campbell ,  Chuen Chan ,  Henry Kelly ,  Nigel King ,  Savvas Kleanthous ,  Andrew Mason ,  Stefan Senger ,  Paul Smith ,  Nigel Watson ,  Robert Young

IPC分类号： A61K31/4015 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  A61K38/00 ,  A61K38/55 ,  A61P3/00 ,  A61P7/00 ,  A61P7/02 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/04 ,  A61P41/00 ,  A61P43/00 ,  C07D207/26 ,  C07D207/273 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07K1/02 ,  C07K5/06 ,  A61K31/535

CPC分类号： C07D207/273 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

摘要： The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a Factor Xa inhibitor using the same.

摘要翻译： 本发明涉及式（I）化合物，其含有相同的药物组合物，以及治疗患有易因因子Xa抑制剂改善的病症的患者的方法。

公开(公告)号：US20100144908A1

公开(公告)日：2010-06-10

申请号：US12329938

申请日：2008-12-08

申请人： Matthew Campbell ,  John Sarlis ,  Vijay Bhambhani Godhwani ,  Melina Infantino

发明人： Matthew Campbell ,  John Sarlis ,  Vijay Bhambhani Godhwani ,  Melina Infantino

IPC分类号： B01J49/00

CPC分类号： B01D53/1481 ,  B01D53/1425 ,  B01D2252/2041 ,  B01J49/53

摘要： A diamine absorbent that contains heat stable salts is regenerated using an ion exchange process wherein the cation exchange resin is regenerated using sulfurous acid reflux.

摘要翻译： 含有热稳定盐的二胺吸收剂使用离子交换方法再生，其中阳离子交换树脂使用亚硫酸回流再生。

公开(公告)号：US09127003B2

公开(公告)日：2015-09-08

申请号：US14416937

申请日：2012-07-26

申请人： Stephen John Atkinson ,  Michael David Barker ,  Matthew Campbell ,  Hawa Diallo ,  Clement Douault ,  Neil Stuart Garton ,  John Liddle ,  Robert John Sheppard ,  Ann Louise Walker ,  Christopher Wellaway ,  David Matthew Wilson

发明人： Stephen John Atkinson ,  Michael David Barker ,  Matthew Campbell ,  Hawa Diallo ,  Clement Douault ,  Neil Stuart Garton ,  John Liddle ,  Robert John Sheppard ,  Ann Louise Walker ,  Christopher Wellaway ,  David Matthew Wilson

IPC分类号： C07D471/04 ,  A61K31/407 ,  A61K31/4184

CPC分类号： A61K31/4545 ,  A61K31/407 ,  A61K31/4184 ,  C07D471/04

摘要： Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

摘要翻译： 式（I）的化合物：其中; R1是氢或C1-6烷基; R 2是氢，C 1-6烷基，全卤代甲基C 0-5烷基-O-或C 1-6烷氧基; R3是氢，C1-6烷基或C1-6烷氧基C1-6烷基; R 4是氢，C 1-6烷基，全卤代甲基C 1-6烷基; 或未取代的C 3-6环烷基C 1-6烷基; A为C-R5或N; B为C-R6或N; D为C-R7或N; 条件是A，B和D中的至少一个为N; R5是氢或C1-6烷基; R6是氢或C1-6烷基; R7是氢，C1-6烷基，C1-6烷氧基或羟基; R8是氢或C1-6烷基，条件是R4和R8中的一个是氢; R9是氢或羟基; R 10是氢或C 1-6烷基; 其盐是PAD4抑制剂，并且可用于治疗各种疾病，例如类风湿性关节炎，血管炎，系统性红斑狼疮，溃疡性结肠炎，癌症，囊性纤维化，哮喘，皮肤红斑狼疮和牛皮癣。

公开(公告)号：US20110064792A1

公开(公告)日：2011-03-17

申请号：US12682331

申请日：2008-10-13

申请人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia King

发明人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia King

IPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K38/00 ,  A61K38/43 ,  A61P25/28 ,  A61P25/00 ,  A61P35/00 ,  A61P27/02 ,  C12N5/071

CPC分类号： C12N15/1138 ,  A61K31/713 ,  A61K45/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

摘要翻译： 本发明涉及RNA干扰（RNAi）用于血脑屏障和/或血液视网膜屏障的紧密连接的瞬时，可逆和受控打开的方法和用途。 该方法可用于治疗需要开启血脑屏障和/或血液视网膜屏障的许多疾病和病症。 这样的方法通常涉及使用RNAi诱导剂，例如siRNA，miRNA，shRNA或RNAi诱导载体，其在细胞内的存在导致产生siRNA或shRNA，靶向紧密连接蛋白以打开血脑屏障 和/或血液视网膜屏障。

公开(公告)号：US20100126425A9

公开(公告)日：2010-05-27

申请号：US11428060

申请日：2006-06-30

申请人： Tyler Ortego ,  Robert Beine ,  Steven Hall ,  Matthew Campbell

发明人： Tyler Ortego ,  Robert Beine ,  Steven Hall ,  Matthew Campbell

IPC分类号： A01K61/00

CPC分类号： A01K61/70 ,  A01K61/54 ,  Y02A40/822 ,  Y02A40/83

摘要： Structures constructed from an artificial material facilitate the setting and growing of oysters, other mollusks, and other organisms for the purposes of food production, artificial reefs/breakwaters, and the like. The artificial material is a composite that acts as both an attractant and nutrient environment for mollusks and other aquatic organisms. The binder for the composite material includes both cement and an organic material. The organic material is selected to attract and feed the aquatic organisms.

摘要翻译： 由人造材料构成的结构有助于牡蛎，其他软体动物和其他生物体的设置和生长，用于粮食生产，人造珊瑚礁/防波堤等。 人造材料是软体动物和其他水生生物作为引诱剂和营养环境的复合材料。 用于复合材料的粘合剂包括水泥和有机材料。 选择有机材料来吸引和饲养水生生物。

公开(公告)号：US20070107663A1

公开(公告)日：2007-05-17

申请号：US11428060

申请日：2006-06-30

申请人： Tyler Ortego ,  Robert Beine ,  Steven Hall ,  Matthew Campbell

发明人： Tyler Ortego ,  Robert Beine ,  Steven Hall ,  Matthew Campbell

IPC分类号： A01K61/00

CPC分类号： A01K61/70 ,  A01K61/54 ,  Y02A40/822 ,  Y02A40/83

摘要： Structures constructed from an artificial material facilitate the setting and growing of oysters, other mollusks, and other organisms for the purposes of food production, artificial reefs/breakwaters, and the like. The artificial material is a composite that acts as both an attractant and nutrient environment for mollusks and other aquatic organisms. The binder for the composite material includes both cement and an organic material. The organic material is selected to attract and feed the aquatic organisms.

摘要翻译： 由人造材料构成的结构有助于牡蛎，其他软体动物和其他生物体的设置和生长，用于粮食生产，人造珊瑚礁/防波堤等。 人造材料是软体动物和其他水生生物作为引诱剂和营养环境的复合材料。 用于复合材料的粘合剂包括水泥和有机材料。 选择有机材料来吸引和饲养水生生物。

公开(公告)号：US20200312174A1

公开(公告)日：2020-10-01

申请号：US16853385

申请日：2020-04-20

申请人： Chantal Jandard ,  Matthew Campbell ,  Dana Marr ,  Rylan Cottrell ,  Joseph Wong ,  Claudia Peralta ,  Josh Cheung

发明人： Chantal Jandard ,  Matthew Campbell ,  Dana Marr ,  Rylan Cottrell ,  Joseph Wong ,  Claudia Peralta ,  Josh Cheung

IPC分类号： G09B5/08 ,  G09B5/06 ,  G09B7/02

摘要： A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

公开(公告)号：US10657835B2

公开(公告)日：2020-05-19

申请号：US14629098

申请日：2015-02-23

申请人： Chantal Jandard ,  Matthew Campbell ,  Dana Marr ,  Rylan Cottrell ,  Joseph Wong ,  Claudia Peralta ,  Josh Cheung

发明人： Chantal Jandard ,  Matthew Campbell ,  Dana Marr ,  Rylan Cottrell ,  Joseph Wong ,  Claudia Peralta ,  Josh Cheung

IPC分类号： G09B5/08 ,  G09B5/06 ,  G09B7/02

摘要： A method for completing a project using a content-generating device. The method includes receiving a task defining a content item to be generated, restricting operation of at least a first component of the content-generating device, operating at least a second component of the content-generating device to generate the content item, and making available the generated content item.

公开(公告)号：US09540649B2

公开(公告)日：2017-01-10

申请号：US12682331

申请日：2008-10-13

申请人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia Kiang

发明人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia Kiang

IPC分类号： C12N15/11 ,  C12N15/113 ,  C07H21/04

CPC分类号： C12N15/1138 ,  A61K31/713 ,  A61K45/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

摘要翻译： 本发明涉及RNA干扰（RNAi）用于血脑屏障和/或血液视网膜屏障的紧密连接的瞬时，可逆和受控打开的方法和用途。 该方法可用于治疗需要开启血脑屏障和/或血液视网膜屏障的许多疾病和病症。 这样的方法通常涉及使用RNAi诱导剂，例如siRNA，miRNA，shRNA或RNAi诱导载体，其在细胞内的存在导致产生siRNA或shRNA，靶向紧密连接蛋白以打开血脑屏障 和/或血液视网膜屏障。