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公开(公告)号：US08207147B2
公开(公告)日：2012-06-26
申请号：US10584025
申请日：2004-12-23
申请人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , John King-Underwood , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Gerard Hugh Thomas
发明人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , John King-Underwood , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Gerard Hugh Thomas
IPC分类号： A61K31/66 , A61K31/497 , A61K31/4523 , C07D401/14 , C07F9/02 , C07D211/00 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/14
摘要： Compounds of Formula (I), R1-A-V—B—R2; or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.
摘要翻译： 式（I）的化合物，R1-A-V-B-R2; 或其药学上可接受的盐是GPR116的激动剂，并且可用作饱腹感的调节剂，例如， 用于治疗肥胖症和治疗糖尿病。
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公开(公告)号：US07214681B2
公开(公告)日：2007-05-08
申请号：US10776584
申请日：2004-02-10
申请人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
发明人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
IPC分类号： A61K31/502 , C07D43/02
CPC分类号： C07D231/12 , C07D211/34 , C07D213/55 , C07D233/56 , C07D249/08 , C07D277/30 , C07D277/40 , C07D277/46 , C07D307/54 , C07D309/04 , C07D309/08 , C07D333/24 , C07D333/28 , C07D335/02 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/10 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/08
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US07582632B2
公开(公告)日：2009-09-01
申请号：US11735685
申请日：2007-04-16
申请人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
发明人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Karen Lesley Schofield , Vilasben Kanji Shah , Kosuke Yasuda
IPC分类号： A61K31/4433 , A61P3/00 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/12 , C07D211/34 , C07D213/55 , C07D233/56 , C07D249/08 , C07D277/30 , C07D277/40 , C07D277/46 , C07D307/54 , C07D309/04 , C07D309/08 , C07D333/24 , C07D333/28 , C07D335/02 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/10 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/08
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US07262196B2
公开(公告)日：2007-08-28
申请号：US10776559
申请日：2004-02-10
申请人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Geoffrey Martyn Williams , David Witter , Arlindo Castelhano , Kosuke Yasuda
发明人： Matthew Colin Thor Fyfe , Lisa Sarah Gardner , Maseo Nawano , Martin James Procter , Chrystelle Marie Rasamison , Geoffrey Martyn Williams , David Witter , Arlindo Castelhano , Kosuke Yasuda
IPC分类号： A61K31/498 , A61K31/506 , C07D43/14
CPC分类号： C07D401/04 , C07D213/55 , C07D213/61 , C07D213/70 , C07D213/75 , C07D239/38 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts or N-oxides thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐或N-氧化物可用于预防和治疗高血糖症和糖尿病。
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公开(公告)号：US20090221644A1
公开(公告)日：2009-09-03
申请号：US11922830
申请日：2006-06-29
申请人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
发明人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
IPC分类号： A61K31/443 , C07D405/12 , A61P3/10
CPC分类号： C07D471/04 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US20120172358A1
公开(公告)日：2012-07-05
申请号：US13396193
申请日：2012-02-14
申请人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse , Simon Andrew Swain , Geoffrey Martyn Williams
发明人： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse , Simon Andrew Swain , Geoffrey Martyn Williams
IPC分类号： A61K31/445 , C07D401/10 , C07D413/12 , C07D401/04 , A61K31/454 , A61P3/06 , A61K31/496 , A61K31/5377 , A61K31/506 , A61P3/00 , A61P3/04 , A61P3/10 , C07D211/34 , A61K31/4545
CPC分类号： C07D401/14 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/34 , C07D211/48 , C07D401/04 , C07D401/10 , C07D401/12
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US20090325924A1
公开(公告)日：2009-12-31
申请号：US11922765
申请日：2006-06-29
申请人： Stuart Edward , Graham John Dawson , Matthew Colin Thor Fyfe Oxford , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Neela Sumit Mistry , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse
发明人： Stuart Edward , Graham John Dawson , Matthew Colin Thor Fyfe Oxford , Lisa Sarah Bertram , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Neela Sumit Mistry , Martin James Procter , Chrystelle Marie Rasamison , Philip John Rushworth , Colin Peter Sambrook-Smith , David French Stonehouse
IPC分类号： A61K31/4245 , C07D413/14 , C07D413/12 , C07D271/06 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/506 , A61P3/00
CPC分类号： C07D271/06 , C07D401/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US20110212939A1
公开(公告)日：2011-09-01
申请号：US13003571
申请日：2009-07-10
申请人： Lisa Sarah Bertram , Philip Graham Clarke , Graham John Dawson , Peter Timothy Fry , Matthew Colin Thor Fyfe , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Thomas Martin Krulle , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Simon Andrew Swain
发明人： Lisa Sarah Bertram , Philip Graham Clarke , Graham John Dawson , Peter Timothy Fry , Matthew Colin Thor Fyfe , William Gattrell , Revathy Perpetua Jeevaratnam , John Keily , Thomas Martin Krulle , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Simon Andrew Swain
IPC分类号： A61K31/397 , C07D401/04 , A61K31/506 , C07D401/14 , A61K31/4965 , A61K31/454 , A61K31/4725 , A61K31/4709 , A61K31/517 , A61P3/00
CPC分类号： C07D401/12 , C07D295/205 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR（GPR119）激动剂，可用于治疗糖尿病和肥胖症。
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公开(公告)号：US20090203676A1
公开(公告)日：2009-08-13
申请号：US11922826
申请日：2006-06-30
申请人： Oscar Barba , Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Simon Andrew Swain
发明人： Oscar Barba , Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Simon Andrew Swain
IPC分类号： A61K31/496 , C07D401/06 , C07D401/14 , C07D413/14 , C07D497/08 , A61K31/551 , A61K31/454 , A61P3/04 , A61P3/10 , A61P3/00
CPC分类号： C07D401/04 , C07D211/20 , C07D211/26 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D487/08
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译： 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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公开(公告)号：US20120214808A1
公开(公告)日：2012-08-23
申请号：US13399517
申请日：2012-02-17
申请人： Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Simon Andrew Swain , Philippe Wong-Kai-In
发明人： Jason Bloxham , Matthew Colin Thor Fyfe , James Horswill , Revathy Perpetua Jeevaratnam , John Keily , Martin James Procter , Karen Lesley Schofield , Salam Shaaban , Simon Andrew Swain , Philippe Wong-Kai-In
IPC分类号： A61K31/5377 , C07D277/38 , A61K31/381 , C07D333/50 , C07D333/36 , A61K31/17 , C07C275/42 , A61K31/4164 , C07D233/56 , A61K31/428 , C07D277/82 , A61K31/44 , C07D213/72 , A61K31/5375 , C07D295/12 , A61K31/505 , C07D239/02 , C07D413/04 , A61P3/04 , A61P25/18 , A61P25/24 , A61P3/00 , A61P25/08 , A61P25/00 , A61K31/426
CPC分类号： A61K31/381 , A61K31/341 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/455
摘要： A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.
摘要翻译： 通过向需要这种治疗的受试者施用有效量的芳基脲CB-1受体调节化合物来治疗与CB-1受体相关的病症，特别是肥胖症的方法。
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