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    Purine derivatives as purinergic receptor antagonists
    7.
    发明申请
    Purine derivatives as purinergic receptor antagonists 审中-公开

    公开(公告)号：US20060270691A1

    公开(公告)日：2006-11-30

    申请号：US11488750

    申请日：2006-07-19

    申请人： Roger Gillespie ,  Joanne Lerpiniere ,  Claire Dawson ,  Suneel Gaur ,  Robert Pratt ,  Gemma Stratton ,  Scott Weiss

    发明人： Roger Gillespie ,  Joanne Lerpiniere ,  Claire Dawson ,  Suneel Gaur ,  Robert Pratt ,  Gemma Stratton ,  Scott Weiss

    IPC分类号： A61K31/52 ,  A61K31/522

    CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/28 ,  C07D473/32 ,  C07D473/36 ,  C07D473/40

    摘要： Use of a compound of formula (I) wherein R1 is selected from alkyl, aryl, alkoxy, aryloxy, 0thioalkyl, thioaryl, CN, halo, NR5R6, NR4COR5, NR4CONR5R6, NR4CO2R7 and NR4SO2R7; R2 is selected from N, O or S-containing heteroaryl groups, wherein the heteroaryl group is attached via an unsaturated carbon atom which is adjacent to one or two N, O or S-heteroatom(s), other than ortho, ortho-disubstituted heteroaryl groups; R3 is selected from H, alkyl, COR8, CONR9R10, CONR8NR9R10, CO2R11 and SO2R11; R4, R5 and R6 are independently selected from H, alkyl and aryl or where R5 and R6 are in an (NR5R6) group then R5 and R6 may be linked to form a heterocyclic ring; R7 is selected from alkyl and aryl; R8, R9 and R10 are independently selected from H, alkyl and aryl, or R9 and R10 may be linked to form a heterocyclic ring, or where R8, R9 and R10 are in a (CONR8NR9R10) group, R8 and R9 may be linked to form a heterocyclic group; and R1 is selected from alkyl and aryl, or a pharmaceutically acceptable salt thereof or prodrug thereof, in the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosine receptors and more particularly A2A receptors, may be beneficial, particularly wherein said disorder is a movement disorder such as Parkinson's disease or said disorder is depression, cognitive or memory impairment, acute or chronic pain, ADHD or narcolepsy, or for neuroprotection in a subject; compounds of formula (I) for use in therapy; and novel compounds of formula (I) per se.

    Memorial year round flower display
    9.
    发明授权
    Memorial year round flower display 失效
    纪念年圆花展示

    公开(公告)号：US06092330A

    公开(公告)日：2000-07-25

    申请号：US156591

    申请日：1998-09-18

    申请人： Robert Pratt

    发明人： Robert Pratt

    IPC分类号： A47G7/06 ,  A01G5/00 ,  A01G1/00 ,  E02D19/00

    CPC分类号： A47G7/06

    摘要： A memorial flower display has a receptacle shaped to receive a flower vase. The flower vase has a plurality of engagement studs that engage mating stud receiving channels in the receptacle. The stud receiving channels each have a top slot. When the engagement studs are in the top slots, the flower vase in held in a raised position. When the user twists the flower vase with an upwardly extending handle integral with the flower vase, the engagement studs are twisted out of the top slots, allowing the engagement studs to slide down the stud receiving channels, thereby allowing the flower vase to be lowered into the receptacle to a lowered position. The memorial flower display preferably is covered with a base plate to secure the memorial flower display against theft. The base plate preferably further includes a pair of closure plates that can be moved to cover the memorial flower display for protection.

    摘要翻译： 纪念花展示具有容纳形状以容纳花瓶的容器。 花瓶具有多个接合柱，其接合插座中的配合螺柱接收通道。 螺柱接收通道各自具有顶部槽。 当接合柱头在顶部槽口中时，花瓶保持在升高的位置。 当用户用花瓶与花瓶一体地向上延伸的手柄扭曲花瓶时，将接合柱从顶部槽中扭出，从而允许接合柱沿着螺柱接收通道滑下，从而允许将花瓶降至 容器处于降低位置。 纪念花展示最好用底板覆盖，以保证纪念花展示不被盗窃。 基板优选地还包括一对封闭板，其可以移动以覆盖纪念花卉显示器用于保护。