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    Transdermal patches having ionized beam crosslinked polymers and improved release characteristics
    1.
    发明授权
    Transdermal patches having ionized beam crosslinked polymers and improved release characteristics 有权
    具有电离束交联聚合物的透皮贴剂和改善的释放特性

    公开(公告)号：US08911782B2

    公开(公告)日：2014-12-16

    申请号：US13444348

    申请日：2012-04-11

    申请人： Matthew Harriton ,  Gregory Robb ,  Ronald S. Harland

    发明人： Matthew Harriton ,  Gregory Robb ,  Ronald S. Harland

    IPC分类号： A61K9/14 ,  A61K31/167 ,  A61K9/06 ,  A61K9/70 ,  A61K47/36 ,  A61K47/10 ,  A61K47/32

    CPC分类号： A61K47/10 ,  A61K9/06 ,  A61K9/70 ,  A61K9/7053 ,  A61K31/167 ,  A61K47/32 ,  A61K47/36

    摘要： Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure. The transdermal patches here are particularly effective in delivering lidocaine to patients in need thereof.

    摘要翻译： 交联水凝胶基透皮药物制剂。 水凝胶透皮制剂。 透皮贴剂可用于向患者施用各种药物。 这里的透皮贴剂使用通过照射产生的交联水凝胶，从而消除与化学或UV基交联程序相关的任何残留效应。 透皮贴剂可以由多种高分子量聚合物形成，并且包括大量的水以改善患者的皮肤耐受性。 透皮贴剂还可以包括作为药物的溶剂的转酮醇，其被发现增加药物递送的有效性。 本公开还提供了在水凝胶交联后将药物装载到透皮制剂中的方法，从而通过避免药物暴露于交联程序中使用的辐射来提高稳定性和生物利用度。 这里的透皮贴剂特别有效地将利多卡因递送给有需要的患者。

    Transdermal Patches Having Ionized Beam Crosslinked Polymers and Improved Release Characteristics
    2.
    发明申请
    Transdermal Patches Having Ionized Beam Crosslinked Polymers and Improved Release Characteristics 有权
    具有电离束交联聚合物的透皮贴剂和改善的释放特性

    公开(公告)号：US20130078299A1

    公开(公告)日：2013-03-28

    申请号：US13444348

    申请日：2012-04-11

    申请人： Matthew HARRITON ,  Gregory Robb ,  Ronald S. Harland

    发明人： Matthew HARRITON ,  Gregory Robb ,  Ronald S. Harland

    IPC分类号： A61K47/10 ,  A61K9/70 ,  A61K47/36 ,  A61K31/167 ,  A61K47/32

    CPC分类号： A61K47/10 ,  A61K9/06 ,  A61K9/70 ,  A61K9/7053 ,  A61K31/167 ,  A61K47/32 ,  A61K47/36

    摘要： Crosslinked hydrogel-based transdermal pharmaceutical formulations. The hydrogel transdermal formulations. Transdermal patches are useful for administering a variety of drugs to patients. The transdermal patches here employ crosslinked-hydrogels generated through irradiation, thus eliminating any residual effects associated with chemical- or UV-based crosslinking procedures. The transdermal patches may be formed from a variety of high-molecular weight polymeric compounds and include substantial levels of water to improve skin tolerance by the patient. The transdermal patches may also include transcutol as a solvent for the drug, which has been found to increase the effectiveness of drug delivery. The present disclosure also provides for methods of loading a drug into a transdermal formulation after the crosslinking of the hydrogel, thus improving stability and bioavailability through avoiding exposure of the drug to the radiation used in the crosslinking procedure. The transdermal patches here are particularly effective in delivering lidocaine to patients in need thereof.

    摘要翻译： 交联水凝胶基透皮药物制剂。 水凝胶透皮制剂。 透皮贴剂可用于向患者施用各种药物。 这里的透皮贴剂使用通过照射产生的交联水凝胶，从而消除与化学或UV基交联程序相关的任何残留效应。 透皮贴剂可以由多种高分子量聚合物形成，并且包括大量的水以改善患者的皮肤耐受性。 透皮贴剂还可以包括作为药物的溶剂的转酮醇，其被发现增加药物递送的有效性。 本公开还提供了在水凝胶交联后将药物装载到透皮制剂中的方法，从而通过避免药物暴露于交联程序中使用的辐射来提高稳定性和生物利用度。 这里的透皮贴剂特别有效地将利多卡因递送给有需要的患者。

    Hydrogel having anti-microbial properties
    3.
    发明申请
    Hydrogel having anti-microbial properties 审中-公开
    水凝胶具有抗微生物特性

    公开(公告)号：US20060062854A1

    公开(公告)日：2006-03-23

    申请号：US11233339

    申请日：2005-09-22

    申请人： N. Chandra ,  William McNally ,  Joel Furey ,  Gregory Robb ,  Matthew Harriton

    发明人： N. Chandra ,  William McNally ,  Joel Furey ,  Gregory Robb ,  Matthew Harriton

    IPC分类号： A61K9/14 ,  A61K33/38

    CPC分类号： A61K33/38 ,  A61K9/06

    摘要： A method of making a hydrogel having antimicrobial properties. The hydrogel includes a hydrogel-forming polymer and an anti-microbial agent. The method includes mixing a hydrogel-forming polymer, such as a hydrophilic polymer, with water and cross-linking the polymer and water using an energy source. The method does not require any chemical additive to affect the cross-linking. The anti-microbial agent may be mixed with the hydrogel-forming polymer and water prior to cross-linking. Alternatively, the anti-microbial agent may be applied to a substrate onto which the hydrogel is placed such that the anti-microbial agent or the properties of the agent, or both, migrate into the hydrogel. The substrate may be a liner onto which the hydrogel is placed, a scrim located on or in the hydrogel, or other appropriate device.

    摘要翻译： 制备具有抗微生物性质的水凝胶的方法。 水凝胶包括形成水凝胶的聚合物和抗微生物剂。 该方法包括将形成水凝胶的聚合物如亲水性聚合物与水混合并使用能量源交联聚合物和水。 该方法不需要任何化学添加剂来影响交联。 交联前，抗微生物剂可与水凝胶形成聚合物和水混合。 或者，抗微生物剂可以施用到其上放置水凝胶的基底上，使得抗微生物剂或试剂或两者的性质迁移到水凝胶中。 衬底可以是其上放置水凝胶的衬垫，位于水凝胶上或其中的稀松布或其它合适的装置。