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1.发明授权Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效噻吩取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06753344B2
公开(公告)日：2004-06-22
申请号：US10317751
申请日：2002-12-12
Applicant: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
Inventor： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC: A61K3138
CPC classification number: C07D231/12 , C07D263/32
Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
Abstract translation: 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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公开(公告)号：US06750338B2
公开(公告)日：2004-06-15
申请号：US10268818
申请日：2002-10-10
Applicant: Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
Inventor： Matthew J. Graneto , Michael L. Vazquez , Susan J. Hartmann , Suzanne Metz , John J. Talley , David L. Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC: C07D40104
CPC classification number: C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
Abstract translation: 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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公开(公告)号：US06482955B2
公开(公告)日：2002-11-19
申请号：US09922819
申请日：2001-08-06
Applicant: Matthew J. Graneto , Susan J. Hartmann , Suzanne Metz , John J. Talley , Michael L. Vazquez , David Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
Inventor： Matthew J. Graneto , Susan J. Hartmann , Suzanne Metz , John J. Talley , Michael L. Vazquez , David Brown , Richard M. Weier , Michael A. Stealey , Xiangdong Xu
IPC: C07D2320
CPC classification number: C07D401/14 , C07D231/18 , C07D339/00 , C07D401/04 , C07D405/14 , C07D409/06
Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
Abstract translation: 本发明涉及制备用作p38激酶和COX-2抑制剂的选择的5-取代的吡唑的新方法。
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公开(公告)号：US08097733B2
公开(公告)日：2012-01-17
申请号：US12276779
申请日：2008-11-24
Applicant: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
Inventor： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd Michael Maddux , Matthew William Mahoney , Mark Alan Massa , Kirby Ray Sample , Michelle Ann Schmidt , Ronald Edward Seidel , Jon Gordon Selbo , Michael Brent Tollefson , Richard Alan Vonder Embse , Grace Mary Wagner , Scott Santford Woodard
IPC: C07D231/10
CPC classification number: C07D405/12 , C07D405/14
Abstract: The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及式（I）化合物的制备方法，它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。
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公开(公告)号：US20090227634A1
公开(公告)日：2009-09-10
申请号：US12276779
申请日：2008-11-24
Applicant: Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
Inventor： Edgardo Alvira , Matthew J. Graneto , Margaret Lanahan Grapperhaus , Kaliappan Iyanar , Todd M. Maddux , Matthew W. Mahoney , Mark A. Massa , Kirby R. Sample , Michelle A. Schmidt , Ronald E. Seidel , Jon G. Selbo , Michael B. Tollefson , Richard A. Vonder Embse , Grace M. Wagner , Scott S. Woodard
IPC: A61K31/4439 , A61K31/4178 , A61K31/4162 , C07D405/14 , C07D405/12
CPC classification number: C07D405/12 , C07D405/14
Abstract: The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及式（I）化合物的制备方法，它们作为5-脂肪氧合酶抑制剂的用途和含有它们的药物组合物。
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Patent Agency Ranking
6.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
Applicant: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
Inventor： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC: A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC classification number: C07D231/12 , C07D263/32
Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
Abstract translation: 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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公开(公告)号：US06617324B1
公开(公告)日：2003-09-09
申请号：US10114297
申请日：2002-04-02
Applicant: Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
Inventor： Ashok S. Naraian , Michael Clare , Paul W. Collins , Joyce Zuowu Crich , Rajesh Devraj , Daniel L. Flynn , Lifeng Geng , Matthew J. Graneto , Cathleen E. Hanau , Gunnar J. Hanson , Susan J. Hartmann , Michael Hepperle , He Huang , Francis J. Koszyk , Shuyuan Liao , Suzanne Metz , Richard A. Partis , Thao D. Perry , Shashidhar N. Rao , Shaun Raj Selness , Michael S. South , Michael A. Stealey , John Jeffrey Talley , Michael L. Vazquez , Richard M. Weier , Xiangdong Xi , Ish K. Khanna , Yi Yu
IPC: A61K31496
CPC classification number: C07D409/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D487/04
Abstract: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
Abstract translation: 一类描述用于治疗p38激酶介导的病症的吡唑衍生物。 特别感兴趣的化合物由式IA定义，其中R1，R2，R3和R4如说明书中所述。
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8.发明授权
公开(公告)号：US5563165A
公开(公告)日：1996-10-08
申请号：US457059
申请日：1995-06-01
Applicant: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
Inventor： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC: A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/535
CPC classification number: C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##
Abstract translation: 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：（I）
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公开(公告)号：US5504215A
公开(公告)日：1996-04-02
申请号：US458079
申请日：1995-06-01
Applicant: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
Inventor： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC: A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC classification number: C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
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10.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06696477B2
公开(公告)日：2004-02-24
申请号：US09997633
申请日：2001-11-29
Applicant: John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
Inventor： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas
IPC: C07D23110
CPC classification number: C07D231/12 , B60G17/018 , B60G2400/102 , B60G2400/206 , B60G2400/25 , B60G2400/60 , B60G2400/91 , B64C27/001 , B64C2027/004 , C07D263/32
Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
Abstract translation: 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。 特别感兴趣的化合物由式I定义，其中A，Y，R 1，R 2，R 3，R 4和R 5如说明书中所定义。
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