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    GENE KNOCKOUT MESOPHILIC AND THERMOPHILIC ORGANISMS, AND METHODS OF USE THEREOF
    4.
    发明申请
    GENE KNOCKOUT MESOPHILIC AND THERMOPHILIC ORGANISMS, AND METHODS OF USE THEREOF 失效
    基因克隆夫妇和热休克有机体及其使用方法

    公开(公告)号：US20100297721A1

    公开(公告)日：2010-11-25

    申请号：US12599458

    申请日：2008-05-09

    申请人： David Anthony Hogsett ,  Vineet Badriphrajad Rajgarhia

    发明人： David Anthony Hogsett ,  Vineet Badriphrajad Rajgarhia

    IPC分类号： C12P7/10 ,  C07H21/04 ,  C12N1/21 ,  C12N15/63

    CPC分类号： C12P7/10 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12N15/74 ,  C12P7/065 ,  C12P2203/00 ,  C12Y101/01002 ,  C12Y101/01027 ,  C12Y101/02003 ,  C12Y203/01008 ,  C12Y207/01017 ,  C12Y207/02001 ,  C12Y503/01005 ,  Y02E50/16 ,  Y02E50/17

    摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

    摘要翻译： 本发明的一个方面涉及经遗传修饰的嗜热或嗜温微生物，其中第一天然基因部分，基本上或完全缺失，沉默，失活或下调，所述第一天然基因编码参与 有机酸或其盐的代谢产生，从而增加所述嗜热或嗜温微生物产生乙醇作为发酵产物的天然能力。 在某些实施方案中，上述微生物还包含第一非天然基因，其第一非天然基因编码参与乙醇代谢产生的第一非天然酶。 本发明的另一方面涉及将木质纤维素生物质转化为乙醇的方法，包括使木质纤维素生物质与遗传修饰的嗜热或嗜温微生物接触。

    NOVEL PRODUCTION METHOD OF FLAVOCYTOCHROME B2
    5.
    发明公开
    NOVEL PRODUCTION METHOD OF FLAVOCYTOCHROME B2 审中-公开

    公开(公告)号：US20240254456A1

    公开(公告)日：2024-08-01

    申请号：US18565765

    申请日：2022-06-09

    申请人： DirectSens GmbH

    发明人： Peter HERZOG ,  Beate STEINER ,  Alfons FELICE ,  Christopher SCHULZ

    IPC分类号： C12N9/04 ,  C12Q1/00

    CPC分类号： C12N9/0006 ,  C12Q1/005 ,  C12Y101/02003

    摘要： A recombinant flavocytochrome b2 (FCb2), comprising a mature FCb2 peptide sequence of a native FCb2, or a functionally active variant of said mature FCb2 peptide sequence, wherein the N-terminus of said mature FCb2 peptide sequence consists of a truncated signal peptide sequence replacing the native signal peptide sequence, and wherein said truncated signal peptide sequence is of the following structure from N- to C-terminus: i. a methionine; ii. optionally a tag sequence; iii. an amino acid sequence of a length of 0-9 amino acids of the native signal peptide sequence, corresponding to the amino acid sequence up to 9 amino acids directly upstream of the I/L/V-x-N/A/L motif of the native signal peptide sequence of FCb2; and iv. the I/L/V-x-N/A/L motif, which can be of number 0, 1, or can be partially truncated, wherein if the number is 0 or the I/L/V-x-N/A/L is partially truncated, the length of the amino acid sequence of iii. is 0, wherein the amino acid sequence of said recombinant FCb2 is different from SEQ ID NO: 145.

    Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof
    7.
    发明申请
    Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof 审中-公开
    基因敲除嗜中性和嗜热生物及其使用方法

    公开(公告)号：US20150024450A1

    公开(公告)日：2015-01-22

    申请号：US13888610

    申请日：2013-05-07

    申请人： Mascoma Corporation

    发明人： David Anthony Hogsett ,  Vineet Badriphrajad Rajgarhia

    IPC分类号： C12P7/10 ,  C12N15/74

    CPC分类号： C12P7/10 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12N15/74 ,  C12P7/065 ,  C12P2203/00 ,  C12Y101/01002 ,  C12Y101/01027 ,  C12Y101/02003 ,  C12Y203/01008 ,  C12Y207/01017 ,  C12Y207/02001 ,  C12Y503/01005 ,  Y02E50/16 ,  Y02E50/17

    摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

    摘要翻译： 本发明的一个方面涉及经遗传修饰的嗜热或嗜温微生物，其中第一天然基因部分，基本上或完全缺失，沉默，失活或下调，所述第一天然基因编码参与 有机酸或其盐的代谢产生，从而增加所述嗜热或嗜温微生物产生乙醇作为发酵产物的天然能力。 在某些实施方案中，上述微生物还包含第一非天然基因，其第一非天然基因编码参与乙醇代谢产生的第一非天然酶。 本发明的另一方面涉及将木质纤维素生物质转化为乙醇的方法，包括使木质纤维素生物质与遗传修饰的嗜热或嗜温微生物接触。