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1.发明申请Combined PET/MR Imaging System and APD-Based PET Detector For Use In Simultaneous PET/MR Imaging 有权组合PET / MR成像系统和基于APD的PET检测器，用于同时PET / MR成像公开(公告)号：US20070102641A1
公开(公告)日：2007-05-10
申请号：US11532665
申请日：2006-09-18
申请人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
发明人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译： 提供基于APD的PET模块，用于组合PET / MR成像。 每个模块包括多个独立的光隔离探测器。 每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。 模块位于MR扫描仪的通道中。 基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。
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公开(公告)号：US07772559B2
公开(公告)日：2010-08-10
申请号：US12232451
申请日：2008-09-17
申请人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew Martin , Matthias Schmand
发明人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew Martin , Matthias Schmand
IPC分类号： G01T1/164
CPC分类号： G01T1/1603 , A61B6/037 , G01T7/005
摘要： A method for stabilizing the gain of a PET detection system with a cooling unit includes: determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.
摘要翻译： 用于利用冷却单元稳定PET检测系统的增益的方法包括：确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度 增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。
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公开(公告)号：US08674312B2
公开(公告)日：2014-03-18
申请号：US13426667
申请日：2012-03-22
IPC分类号： G01T1/20
CPC分类号： G01T1/20 , G01T1/22 , G01T1/2978
摘要： A device for detecting ionizing radiation includes a radiation interaction region configured to generate light in response to an interaction with the ionizing radiation, an optical gain medium region in optical communication with the radiation interaction region and configured to amplify the light, and an energy source coupled to the optical gain medium region and configured to maintain a state of population inversion in the optical gain medium region. The optical gain medium region has an emission wavelength that corresponds with a wavelength of the light generated by the radiation interaction region.
摘要翻译： 用于检测电离辐射的装置包括被配置为响应于与电离辐射的相互作用而产生光的辐射相互作用区域，与辐射相互作用区域光学通信并被配置为放大光的光学增益介质区域，以及耦合的能量源 并且被配置为保持光学增益介质区域中的总体反转状态。 光学增益介质区域具有与由辐射相互作用区域产生的光的波长相对应的发射波长。
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公开(公告)号：US20090114827A1
公开(公告)日：2009-05-07
申请号：US12232451
申请日：2008-09-17
申请人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
发明人： Ziad Burbar , James Corbeil , Gregory Hayzen , Sridhar Kuppuswamy , Ralf Ladebeck , Matthew E. Martin , Matthias J. Schmand
CPC分类号： G01T1/1603 , A61B6/037 , G01T7/005
摘要： A method is disclosed for stabilizing the gain of a PET detection system with a cooling unit. The method includes determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.
摘要翻译： 公开了一种用于通过冷却单元稳定PET检测系统的增益的方法。 该方法包括确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度，使得增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。
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5.发明申请MR-Compatible Blood Sampling System For PET Imaging Applications in Combined PET/MR Imaging System 有权MR兼容血液采样系统用于PET / MR成像系统的PET成像应用公开(公告)号：US20090108206A1
公开(公告)日：2009-04-30
申请号：US12260966
申请日：2008-10-29
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.
摘要翻译： 用于PET成像应用的自动采血系统，其可以在MR扫描器的视野（FOV）中或非常接近的范围内操作，例如在组合的MR / PET成像系统中。 辐射检测器使用APD（雪崩光电二极管）从正电子 - 电子湮灭光子被吸收的晶体中收集闪烁光。 必要的伽马屏蔽由合适的屏蔽材料制成，优选钨聚合物复合材料。 由于APD相当小并且磁性不敏感，所以它们可以在无扰动的MR设备的强磁场中操作。
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6.发明授权公开(公告)号：US09606199B2
公开(公告)日：2017-03-28
申请号：US12260966
申请日：2008-10-29
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.
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公开(公告)号：US08630693B2
公开(公告)日：2014-01-14
申请号：US12379812
申请日：2009-03-02
申请人： James Corbeil , Stefan Stocker
发明人： James Corbeil , Stefan Stocker
IPC分类号： A61B5/055
CPC分类号： G01R33/481 , A61B6/037
摘要： In a magnetic resonance device having a PET unit for acquiring positron emission tomography data and a gradient coil, the PET unit includes a carrier tube on which at least one PET detector is arranged. In at least one embodiment, the carrier tube is arranged inside the gradient coil and is displaceably mounted in such a way that access to the PET detector is made possible by its displacement. This allows easy access to the PET detector during maintenance activities.
摘要翻译： 在具有用于获取正电子发射断层摄影数据的PET单元和梯度线圈的磁共振装置中，PET单元包括载体管，其上布置有至少一个PET检测器。 在至少一个实施例中，载体管布置在梯度线圈的内部，并且以可移动的方式安装，使得通过其位移使得对PET检测器的接近成为可能。 这样可以在维护过程中轻松访问PET检测器。
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公开(公告)号：US20090272517A1
公开(公告)日：2009-11-05
申请号：US12453153
申请日：2009-04-30
申请人： James Corbeil , Stefan Stocker
发明人： James Corbeil , Stefan Stocker
CPC分类号： G01T1/1603 , A61B6/037 , A61B6/4417 , A61B6/4488 , A61B6/482 , G01R33/481 , G01T1/1648 , H01L31/024 , H01L31/107
摘要： A facility is disclosed for cooling a detection device. In at least one embodiment, the facility includes at least one first cooling unit, through which a thermal contact to the detection device is able to be established and through which heat arising during operation of the detection device is able to be removed; and at least one second cooling unit, which is arranged so that heat from the environment of the detection device can be discharged through it. In at least one embodiment, this has the advantage of largely shielding the first cooling unit from incident heat which allows the detection device to be efficiently cooled.
摘要翻译： 公开了用于冷却检测装置的设备。 在至少一个实施例中，该设施包括至少一个第一冷却单元，通过该至少一个第一冷却单元能够建立与检测装置的热接触，并且能够移除在检测装置的运行期间产生的热量; 以及至少一个第二冷却单元，其布置成使得来自检测装置的环境的热量可以通过其排出。 在至少一个实施例中，这具有将第一冷却单元从入射热中大大屏蔽的优点，这允许检测装置被有效地冷却。
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公开(公告)号：US6019385A
公开(公告)日：2000-02-01
申请号：US978565
申请日：1997-11-26
申请人： Don Kelley , Carl Sisemore , James Corbeil
发明人： Don Kelley , Carl Sisemore , James Corbeil
摘要： An energy storage device includes, in combination: a vehicle adapted for propulsion via energy supplied by an operator, the vehicle having a pedal crank and a coaster brake hub disposed about an axle of a wheel of the vehicle, the pedal crank and the coaster brake hub being disposed in operable communication for transmitting energy from the pedal crank to the coaster brake hub and thence to the wheel; an energy storage device for selectively storing energy and selectively applying the stored energy, the energy storage device being disposed in operable communication with the pedal crank for transmitting energy from the pedal crank to the energy storage device for storage of the energy, and the energy storage device being disposed in operable communication with the coaster brake hub for selectively transmitting stored energy from the energy storage device to the coaster brake hub; and, combining device for differentially combining instant energy supplied by the operator and the energy storage device so that the energy applied to the coaster brake hub is essentially the sum of the instant energy supplied by the operator and the energy storage device.
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10.发明授权Apparatus and method for image alignment for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanner 有权用于组合正电子发射断层扫描（PET）和磁共振成像（MRI）扫描仪的图像对准的装置和方法公开(公告)号：US07768261B2
公开(公告)日：2010-08-03
申请号：US12109605
申请日：2008-04-25
申请人： Rainer Paul , Matthias J. Schmand , Charles H. Hayden, Jr. , James Corbeil , Christian J. Michel , Ziad Burbar , Volker Matschl
发明人： Rainer Paul , Matthias J. Schmand , Charles H. Hayden, Jr. , James Corbeil , Christian J. Michel , Ziad Burbar , Volker Matschl
IPC分类号： G01V3/00
CPC分类号： G01R33/481 , A61B6/037 , A61B6/583 , G01R33/58 , G01T1/1603
摘要： A phantom and method are provided for co-registering a magnetic resonance image and a nuclear medical image. The phantom includes a first housing defining a first chamber configured to receive a magnetic resonance material upon which magnetic resonance imaging can be performed in order to produce the magnetic resonance image. The phantom also includes three or more second housings configured to be attached to the first housing, where the second housings each define a second chamber configured to receive a radioactive material upon which nuclear imaging can be performed in order to produce the nuclear medical image and upon which the magnetic imaging can be performed in order to produce the magnetic resonance image. The first chamber has a volumetric capacity that is larger than a volumetric capacity of each second chamber.
摘要翻译： 提供了用于共同配准磁共振图像和核医学图像的体模和方法。 幻影包括限定第一室的第一壳体，其被配置为接收磁共振材料，在该共振材料上可进行磁共振成像以产生磁共振图像。 该幻影还包括构造成附接到第一壳体的三个或更多个第二壳体，其中第二壳体每个限定第二室，所述第二室被构造成接收放射性材料，在该第二室上可以执行核成像以产生核医学图像， 可以进行磁性成像以产生磁共振图像。 第一室具有大于每个第二室的容积的容积。
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