公开(公告)号：US5003098A

公开(公告)日：1991-03-26

申请号：US214500

申请日：1988-07-01

申请人： Matti Siren ,  David Blake

发明人： Matti Siren ,  David Blake

IPC分类号： A21D2/00 ,  A21D2/30 ,  A23B7/154 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23L1/015 ,  A23L1/03 ,  A23L1/212 ,  A23L1/30 ,  A23L2/00 ,  A23L3/3553 ,  A61K8/00 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/73 ,  A61K8/97 ,  A61K8/99 ,  A61K31/66 ,  A61K47/22 ,  A61K47/24 ,  A61P3/00 ,  A61P3/06 ,  A61P3/08 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P39/02 ,  C07F9/117 ,  C07H11/04 ,  C09K15/32 ,  C12P9/00

CPC分类号： C07F9/117 ,  A21D2/30 ,  A23B7/154 ,  A23L29/05 ,  A23L3/3553 ,  A61K31/66 ,  A61K47/24 ,  C12P9/00 ,  Y10S514/97

摘要： A method of reducing or eliminating adverse effects of a pharmaceutical composition or a drug is disclosed. The method comprises administering to an animal or a human an amount of at least one specific isomer of inositol triphosphate sufficient to reduce or eliminate said adverse effects.

公开(公告)号：US20130028376A1

公开(公告)日：2013-01-31

申请号：US13548431

申请日：2012-07-13

申请人： Richard Mastronardi ,  David Blake ,  Seth Van Liew ,  Jeffrey Warren

发明人： Richard Mastronardi ,  David Blake ,  Seth Van Liew ,  Jeffrey Warren

IPC分类号： G01N23/04

CPC分类号： G01V5/0008

摘要： A mobile scanning system and methods for inspecting contents of a container. Multiple detector plates are arrayed along an arcuate member coupled to a conveyance with wheels, capable of road travel. A source generates high-energy penetrating radiation that irradiates each of the detector plates from a single position. The arcuate member is disposed, during the course of operation of the system, in a vertical plane. The system has one actuator for rotating the arcuate member about a horizontal pivot into a horizontal plane, and a second actuator for further rotating the arcuate member, once rotated into the horizontal plane, about a vertical pivot, so that the arcuate member is contained, for purposes of transport, entirely within a volume defined by a rectangular prism that does not extend horizontally outward from the conveyance beyond any of its wheels.

摘要翻译： 移动扫描系统和检查容器内容物的方法。 多个检测器板沿着弓形构件排列，弓形构件联接到具有车轮的运输工具，能够行驶。 源产生从单个位置照射每个检测器板的高能穿透辐射。 在系统的操作过程中，弓形构件设置在垂直平面中。 该系统具有一个致动器，用于将弓形构件围绕水平枢轴旋转到水平平面中;以及第二致动器，用于使弓形构件一旦旋转到水平面中，围绕垂直枢轴旋转，使得弓形构件被包含， 为了运输的目的，完全在由直角棱镜限定的体积内，该矩形棱镜不会从输送机水平向外延伸超过其任何轮子。

公开(公告)号：US20050091943A1

公开(公告)日：2005-05-05

申请号：US10701903

申请日：2003-11-05

申请人： David Blake ,  Cory Muhm

发明人： David Blake ,  Cory Muhm

IPC分类号： B65B7/02 ,  B65B31/04 ,  B65B51/04 ,  B65B31/00

CPC分类号： B65B31/041 ,  B65B7/02 ,  B65B51/043

摘要： An packaging apparatus and method to uncuff a package assembly is disclosed. The package assembly includes a container with at least one upstanding sidewall defining an open top. A bag is disposed within the container and a top portion of the bag is folded over the at least one sidewall at the open top to define a cuff. The packaging apparatus includes a first fluid jet directed substantially upward that is configured to uncuff the top portion of the bag from the container. An automatic bag closer gathers the top portion of the bag and applies a clip to close the bag. A second fluid jet is directed substantially downward and is configured to push the top portion of the bag substantially within the container.

摘要翻译： 公开了一种无包装组件的包装装置和方法。 包装组件包括具有限定开口顶部的至少一个直立侧壁的容器。 袋子设置在容器内，并且袋的顶部在开口顶部折叠在至少一个侧壁上以限定袖带。 包装装置包括基本向上指向的第一流体喷射，其构造成从容器中取出袋的顶部。 自动包装袋收集袋的顶部并施加夹子以关闭袋子。 第二流体射流基本向下引导，并且构造成基本上在容器内推动袋的顶部。

公开(公告)号：US20080177711A1

公开(公告)日：2008-07-24

申请号：US12055545

申请日：2008-03-26

申请人： David Blake ,  Michelle Eddie

发明人： David Blake ,  Michelle Eddie

IPC分类号： G06F9/445 ,  G06F17/30

CPC分类号： G06F8/61 ,  Y10S707/966

摘要： A system and method for managing and verifying the installation of software on a modular information handling system includes a bar file database and an installation management module. The bar file database stores bar files. The bar files each are related to a component of a modular information handling system. The installation management module is able to receive a bar file and communicate with the bar file database to identify and access each bar file associated with the modular information handling system.

摘要翻译： 用于管理和验证在模块化信息处理系统上安装软件的系统和方法包括条形文件数据库和安装管理模块。 条形文件数据库存储条形文件。 每个条形码文件都与模块化信息处理系统的组件相关。 安装管理模块能够接收条形文件并与条形文件数据库进行通信，以识别和访问与模块化信息处理系统相关联的每个条形文件。

公开(公告)号：US20060204975A1

公开(公告)日：2006-09-14

申请号：US11242244

申请日：2005-10-03

申请人： Simon Green ,  Sheelagh Frame ,  David Blake

发明人： Simon Green ,  Sheelagh Frame ,  David Blake

IPC分类号： C12Q1/68 ,  A61K31/522

CPC分类号： C12Q1/6886 ,  C12Q2600/136

摘要： The present invention relates to pharmacodynamic markers for CDKIs including the candidate 2,6,9-tri-substituted purine known as roscovitine. The identity of these markers facilitates the convenient identification of roscovitine-like activity both in vitro and in vivo.

摘要翻译： 本发明涉及CDKI的药效学标志物，其包括称为roscovitine的候选2,6,9-三取代嘌呤。 这些标记的身份有助于在体外和体内方便地鉴定类似罗素维生素的活性。

公开(公告)号：US4098905A

公开(公告)日：1978-07-04

申请号：US715074

申请日：1976-08-17

申请人： David Blake ,  Louis Ferstandig

发明人： David Blake ,  Louis Ferstandig

IPC分类号： A61K31/045 ,  A61K31/06 ,  A61K31/13 ,  A61K31/185 ,  C07C31/38

CPC分类号： A61K31/185 ,  A61K31/045 ,  A61K31/06 ,  A61K31/13 ,  C07C31/38

摘要： The ability of a male to impregnate a female is reversibly effected by administering to the male, preferably daily in pill form, an effective amount of a trihalomethyl-containing lower alkanol, aldehyde, acid, amine, ether, or the like, or a derivative such as an amide or salt which liberates such compound in the body. The length of time needed for the male to regain his fertility depends upon the dosage of active material, preferably trifluoroethanol.

公开(公告)号：US08971487B2

公开(公告)日：2015-03-03

申请号：US13548431

申请日：2012-07-13

申请人： Richard Mastronardi ,  David Blake ,  Seth Van Liew ,  Jeffrey Warren

发明人： Richard Mastronardi ,  David Blake ,  Seth Van Liew ,  Jeffrey Warren

IPC分类号： G01V5/00

CPC分类号： G01V5/0008

摘要： A mobile scanning system and methods for inspecting contents of a container. Multiple detector plates are arrayed along an arcuate member coupled to a conveyance with wheels, capable of road travel. A source generates high-energy penetrating radiation that irradiates each of the detector plates from a single position. The arcuate member is disposed, during the course of operation of the system, in a vertical plane. The system has one actuator for rotating the arcuate member about a horizontal pivot into a horizontal plane, and a second actuator for further rotating the arcuate member, once rotated into the horizontal plane, about a vertical pivot, so that the arcuate member is contained, for purposes of transport, entirely within a volume defined by a rectangular prism that does not extend horizontally outward from the conveyance beyond any of its wheels.

摘要翻译： 移动扫描系统和检查容器内容物的方法。 多个检测器板沿着弓形构件排列，弓形构件联接到具有车轮的运输工具，能够行驶。 源产生从单个位置照射每个检测器板的高能穿透辐射。 在系统的操作过程中，弓形构件设置在垂直平面中。 该系统具有一个致动器，用于将弓形构件围绕水平枢轴旋转到水平平面中;以及第二致动器，用于使弓形构件一旦旋转到水平面中，围绕垂直枢轴旋转，使得弓形构件被包含， 为了运输的目的，完全在由直角棱镜限定的体积内，该矩形棱镜不会从输送机水平向外延伸超过其任何轮子。

公开(公告)号：US07829555B1

公开(公告)日：2010-11-09

申请号：US09367261

申请日：1998-02-13

申请人： David Blake ,  Declan Naughton ,  Ged Adams ,  Margaret Adams, legal representative ,  Ian Stratford ,  Christopher Morris ,  Mohammed Jaffar ,  Matthew Naylor

发明人： David Blake ,  Declan Naughton ,  Ged Adams ,  Ian Stratford ,  Christopher Morris ,  Mohammed Jaffar ,  Matthew Naylor

IPC分类号： A61K31/573 ,  C07J5/00

CPC分类号： A61K47/559

摘要： The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.

摘要翻译： 本发明提供了将药物靶向体内缺氧和/或缺血组织的区域的方法，其中所需药物物种与非细胞毒性生物还原载体连接。 本发明还提供了包含与至少一种治疗剂连接的非细胞毒性生物还原性部分的新型生物还原性缀合物。 本发明的化合物特别适用于治疗类风湿性关节炎和其他关节炎病症，糖尿病，动脉粥样硬化，中风，败血症，阿尔茨海默病和其他神经障碍，癌症，肾脏疾病，消化系统疾病，肝病，慢性牙周炎或缺血后续 组织移植。

公开(公告)号：US20090234263A1

公开(公告)日：2009-09-17

申请号：US12297693

申请日：2007-04-20

申请人： James Doel ,  David Blake ,  Nigel Harris ,  Brian Bryden

发明人： James Doel ,  David Blake ,  Nigel Harris ,  Brian Bryden

IPC分类号： A61F5/00

CPC分类号： A61F5/05816 ,  A61F5/05833 ,  A61G7/05753 ,  A61G7/065

摘要： A support device (1) comprises a first support structure (6) which is conformable to an object to be supported, and a second support structure (2) which has an activated state in which the second support structure substantially locks the first support structure into a conformed shape, and supports tensile loading on the support device, and an inactivated state in which the first support structure is able to conform to an object.

摘要翻译： 支撑装置（1）包括与待支撑物体一致的第一支撑结构（6）和具有激活状态的第二支撑结构（2），其中第二支撑结构将第一支撑结构基本上锁定到 并且支撑在支撑装置上的拉伸载荷，以及第一支撑结构能够与物体一致的非活动状态。

公开(公告)号：US07360212B2

公开(公告)日：2008-04-15

申请号：US10682621

申请日：2003-10-09

申请人： David Blake ,  Michelle Eddie

发明人： David Blake ,  Michelle Eddie

IPC分类号： G06F9/445

CPC分类号： G06F8/61 ,  Y10S707/966

摘要： A system and method for managing and verifying the installation of software on a modular information handling system includes a bar file database and an installation management module. The bar file database stores bar files. The bar files each are related to a component of a modular information handling system. The installation management module is able to receive a bar file and communicate with the bar file database to identify and access each bar file associated with the modular information handling system.

摘要翻译： 用于管理和验证在模块化信息处理系统上安装软件的系统和方法包括条形文件数据库和安装管理模块。 条形文件数据库存储条形文件。 每个条形码文件都与模块化信息处理系统的组件相关。 安装管理模块能够接收条形文件并与条形文件数据库进行通信，以识别和访问与模块化信息处理系统相关联的每个条形文件。