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公开(公告)号：US20210387966A1
公开(公告)日：2021-12-16
申请号：US17289123
申请日：2019-10-31
发明人： Ashok Arasappan , Ian M. Bell , Michael J. Breslin , Christopher James Bungard , Christopher S. Burgey , Harry R. Chobanian , Jason M. Cox , Anthony T. Ginnetti , Deodial Guy Guiadeen , Kristen L. G. Jones , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Shawn J. Stachel , Linda M. Suen-Lai , Zhe Wu
IPC分类号： C07D401/14 , C07D471/04 , C07D413/14 , C07D471/08 , C07D495/04 , C07D401/12 , C07D487/04 , C07D491/048
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号：US11377438B2
公开(公告)日：2022-07-05
申请号：US16669598
申请日：2019-10-31
发明人： Ashok Arasappan , Ian M. Bell , Michael J. Breslin , Christopher James Bungard , Christopher S. Burgey , Harry R. Chobanian , Jason M. Cox , Anthony T. Ginnetti , Deodial Guy Guiadeen , Kristen L. G. Jones , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Shawn J. Stachel , Linda M. Suen-Lai , Zhe Wu
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D471/08 , C07D487/04 , C07D491/048 , C07D495/04
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号：US10214546B2
公开(公告)日：2019-02-26
申请号：US15538971
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D519/00 , A61K45/06 , A61K31/4985 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：US10130630B2
公开(公告)日：2018-11-20
申请号：US15538976
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Abdul-Basit Alhassan , Rajan Anand , Sobhana Babu Boga , Deodial Guy Guiadeen , Wensheng Yu , Younong Yu , Shilan Liu , Hao Wu , Chundao Yang
IPC分类号： A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D519/00 , A61K45/06 , C07K16/28
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：US20230365533A1
公开(公告)日：2023-11-16
申请号：US18040896
申请日：2021-08-16
申请人： Stephane L. BOGEN , Dane James CLAUSEN , Deodial Guy GUIADEEN , Jinsong HAO , Shishi LIN , Michael T. RUDD , Lan WEI , Li XIAO , Dexi YANG , MERCK SHARP & DOHME CORP.
发明人： Stephane L. Bogen , Dane James Clausen , Deodial Guy Guiadeen , Jinsong Hao , Shishi Lin , Michael T. Rudd , Lan Wei , Li Xiao , Dexi Yang
IPC分类号： C07D403/12 , C07D403/14 , C07D417/12 , C07D491/048
CPC分类号： C07D403/12 , C07D403/14 , C07D417/12 , C07D491/048
摘要： The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
where
is
wherein n is 0 or 1;-
公开(公告)号：US11098029B2
公开(公告)日：2021-08-24
申请号：US16787201
申请日：2020-02-11
IPC分类号： C07D401/14 , C07D207/16 , C07D403/12 , C07D409/12
摘要： The present invention is directed to 5-alkyl pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US10087188B2
公开(公告)日：2018-10-02
申请号：US15538902
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Abdul-Basit Alhassan , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jyhshing Wang , Wensheng Yu , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/5377
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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![Substituted imidazo[1,5-a]pyrazines as Btk inhibitors](/abs-image/US/2018/08/07/US10040805B2/abs.jpg.150x150.jpg)
公开(公告)号：US10040805B2
公开(公告)日：2018-08-07
申请号：US15538957
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Xiaolei Gao , Deodial Guy Guiadeen , Shilan Liu , Dahai Wang
IPC分类号： A61K31/4985 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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