专利检索 ap:("Michael A. Brook" OR "Yongxin Wang" OR "Yang Chen") AND inv:"Michael A. Brook" 第 1 页

1.

发明授权
Surface-modifying silicone elastomers 有权
标题翻译：表面改性硅氧烷弹性体

公开(公告)号：US08648211B2

公开(公告)日：2014-02-11

申请号：US13392568

申请日：2010-08-27

申请人： Michael A. Brook , Yongxin Wang , Yang Chen

发明人： Michael A. Brook , Yongxin Wang , Yang Chen

IPC分类号： C08G77/38 , C07F7/00

CPC分类号： C08J7/12 , C07F7/0838 , C08G77/045 , C08G77/12 , C08G77/20 , C08G77/46 , C09D183/12

摘要： The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.

摘要翻译： 本公开内容描述了式（I）的化合物，其中m为1至6，n为6至10，并且R 1为直链或支链硅氧烷，它们用于改性疏水性底物表面以使底物超亲水性和表面改性基质。

2.

发明申请
SURFACE-MODIFYING SILICONE ELASTOMERS 有权
标题翻译：表面改性硅氧烷弹性体

公开(公告)号：US20120226001A1

公开(公告)日：2012-09-06

申请号：US13392568

申请日：2010-08-27

申请人： Michael A. Brook , Yongxin Wang , Wang Chen

发明人： Michael A. Brook , Yongxin Wang , Wang Chen

IPC分类号： C08G77/38 , C07F7/08

CPC分类号： C08J7/12 , C07F7/0838 , C08G77/045 , C08G77/12 , C08G77/20 , C08G77/46 , C09D183/12

摘要： The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.

摘要翻译： 本公开内容描述了式（I）的化合物，其中m为1至6，n为6至10，并且R 1为直链或支链硅氧烷，它们用于改性疏水性底物表面以使底物超亲水性和表面改性基质。

3.

发明授权
Protein compatible methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes 有权
标题翻译：用于控制衍生自多元醇改性硅烷的二氧化硅的形态和收缩的蛋白质相容方法和化合物

公开(公告)号：US07375168B2

公开(公告)日：2008-05-20

申请号：US10814123

申请日：2004-04-01

申请人： Zheng Zhang , Yang Chen , Jorge Cruz-Aguado , Richard J. Hodgson , Dina Tleugabulova , John D. Brennan , Michael A. Brook

发明人： Zheng Zhang , Yang Chen , Jorge Cruz-Aguado , Richard J. Hodgson , Dina Tleugabulova , John D. Brennan , Michael A. Brook

IPC分类号： C08L83/02

CPC分类号： B01J20/28085 , A61K47/52 , B01D15/3804 , B01J20/103 , B01J20/28014 , B01J20/28042 , B01J20/28083 , B01J20/28092 , B01J20/283 , B01J20/286 , B01J2220/82 , C01B33/12 , C01B33/16 , C04B35/14 , C04B35/624 , C04B35/62605 , C04B35/62655 , C04B35/632 , C04B35/634 , C04B38/0045 , C04B2235/441 , C04B2235/77 , G01N15/088 , G01N2030/528 , C04B38/0064

摘要： Siliceous materials were prepared by adding one or more additives, including one or more water soluble polymers, and derivatives thereof, as well as trifunctional silanes, to sols containing tetraalkoxysilanes derived from polyols. The polymers facilitate phase separation of the growing silica gel matrix, leading to high surface area self-supporting silica gels with cure occurring at ambient temperatures. The materials also show a significant reduction in shrinkage properties and significant protein stabilization abilities.

摘要翻译： 通过向包含衍生自多元醇的四烷氧基硅烷的溶胶中加入一种或多种添加剂，包括一种或多种水溶性聚合物及其衍生物以及三官能硅烷来制备硅质材料。聚合物促进生长硅胶基质的相分离，导致高表面积自支撑硅胶，其固化在环境温度下发生。这些材料还显示收缩性能和显着的蛋白质稳定化能力的显着降低。

4.

发明申请
METHODS AND COMPOUNDS FOR FORMING MONOLITHIC TITANIA, OPTIONALLY BIOMOLECULE DOPED, WITH CONTROLLED MORPHOLOGY USING BIOCOMPATIBLE SOL-GEL PROCESSES 审中-公开
标题翻译：用生物易溶性凝胶法制备单晶钛铁矿，选择性生物分子，控制形态的方法和化合物

公开(公告)号：US20100239493A1

公开(公告)日：2010-09-23

申请号：US12442434

申请日：2007-09-24

申请人： Yunyu Yi , Michael A. Brook , John D. Brennan , Yang Chen

发明人： Yunyu Yi , Michael A. Brook , John D. Brennan , Yang Chen

IPC分类号： C01G23/047 , C07F7/28 , C07H23/00

CPC分类号： B01J20/0211 , B01J20/06 , B01J20/282 , B82Y30/00 , C01G23/047 , C01G23/053 , C01P2002/52 , C01P2002/72 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/62 , C01P2006/64 , C01P2006/82 , C07F7/003 , C12N9/104 , C12N11/14 , C12Y203/02002

摘要： The present invention includes polyol modified titanium compounds, their preparation and use in methods to make biomolecule compatible monolithic titania. The invention also includes the use of the biomolecule compatible monolithic titania in bioanalytic applications, for example in biosensors, chromatographic columns, microarrays and bioaffinity columns.

摘要翻译： 本发明包括多元醇改性的钛化合物，它们的制备和用于制备生物分子相容的整体式二氧化钛的方法。本发明还包括在生物分析应用中使用生物分子相容的整体二氧化钛，例如在生物传感器，色谱柱，微阵列和生物亲和柱中。

5.

发明申请
PREPARATION OF ORGANOSILICON-CONTAINING TRIAZOLES 审中-公开
标题翻译：含有机硅的TRIAZOLES的制备

公开(公告)号：US20110077365A1

公开(公告)日：2011-03-31

申请号：US12648395

申请日：2009-12-29

申请人： Gilbert Yu , Ferdinand Gonzaga , Michael A. Brook

发明人： Gilbert Yu , Ferdinand Gonzaga , Michael A. Brook

IPC分类号： C08G77/388 , C07F7/10 , C08G77/26

CPC分类号： C07F7/0889 , C07F7/0838 , C08G77/20 , C08G77/26 , C08G77/38

摘要： The disclosure includes methods for preparing organosilicon-containing 1,2,3-triazoles by reacting an organosilicon containing azide with an alkyne compound or an organosilicon containing alkyne with an azide compound under thermal reaction conditions.

摘要翻译： 本公开内容包括通过在热反应条件下使含有叠氮化物的有机硅与含炔化合物或含炔烃的有机硅与叠氮化合物反应制备含有有机硅的1,2,3-三唑的方法。

6.

发明申请
STABILIZED GOLD NANOPARTICLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：稳定的金纳米颗粒及其制备方法

公开(公告)号：US20100173347A1

公开(公告)日：2010-07-08

申请号：US12593719

申请日：2008-04-02

申请人： Michael A. Brook , Yingfu Li , Ferdinand Gonzaga , Weian Zhao , Monsur M. Ali , Sergio D. Aguirre

发明人： Michael A. Brook , Yingfu Li , Ferdinand Gonzaga , Weian Zhao , Monsur M. Ali , Sergio D. Aguirre

IPC分类号： C12Q1/02 , C07H21/02 , C07F1/12 , G01N21/00 , C12Q1/00 , C07H21/04

CPC分类号： G01N33/532 , B22F1/0022 , B22F1/0062 , B22F9/24 , B82Y5/00 , B82Y30/00 , G01N33/585

摘要： The present disclosure relates to water-soluble stable gold nanoparticles (AuNPs) and methods for making the same. The present disclosure also includes the use of AuNPs, for example, in biological, medical and environmental assays for the detection of analytes, as well as biological and medical imaging.

摘要翻译： 本公开涉及水溶性稳定金纳米颗粒（AuNP）及其制备方法。本公开还包括使用AuNP，例如在用于检测分析物的生物，医学和环境测定中，以及生物和医学成像。

7.

发明公开
METHODS FOR PREPARATION OF KERATIN FIBER COLOR COATINGS WITH AN ORGANIC POLYMER - ALKOXYSILYL COMPOSITION 审中-公开

公开(公告)号：US20230338262A1

公开(公告)日：2023-10-26

申请号：US18003154

申请日：2021-06-29

申请人： Mathias Kurt HERRLEIN , Graham Neil MCKELVEY , Matija CRNE , Simon Paul GODFREY , Corinne Violette MOHR , Ingo WEBER , Swapna PINAKATTU , Patrick Alexander KIEFER , Petra Barbara BRAUN , Andrej GROSS , Felix HERKNER , Galina GROSS , Axel MEYER , Carl Uwe Oswald Ludwig SCHMIDT, , Timothy Robert CLARK , Juergen Karl Anton SCHATZ , Claus SCHREINER , Heiko BAUKNECHT , Michael A. BROOK , WELLA GERMANY GMBH

发明人： Mathias Kurt Herrlein , Graham Neil McKelvey , Matija CRNE , Simon Paul Godfrey , Corinne Violette Mohr , Ingo Weber , Swapna Pinakattu , Patrick Alexander Kiefer , Petra Barbara Braun , Andrej Gross , Felix Herkner , Galina GROSS , Axel Meyer , Carl Uwe Oswald Ludwig Schmidt , Timothy Robert Clark , Jürgen Karl Anton Schatz , Claus Schreiner , Heiko Bauknecht , Michael A. Brook

IPC分类号： A61K8/58 , A61Q5/10 , A45D19/00

CPC分类号： A61K8/585 , A61Q5/10 , A45D19/0066 , A61K2800/95 , A61K2800/884 , A61K2800/43

摘要： The methods and compositions of the present invention are directed to coloration of anagenic hair. The methods involve priming and deep cleaning the anagenic hair followed by coating the hair strands with a composite pigment containing film of a small molecule and a film forming composition which covalently interact to form an intimate three dimensional silicone network incorporating the pigment on the surfaces of the hair.

8.

发明申请
Photo-responsive delivery system 审中-公开
标题翻译：照片响应传送系统

公开(公告)号：US20090028946A1

公开(公告)日：2009-01-29

申请号：US12149940

申请日：2008-05-09

申请人： Heather Sheardown , Michael A. Brook , Laura Wells

发明人： Heather Sheardown , Michael A. Brook , Laura Wells

IPC分类号： A61K9/10

CPC分类号： A61K41/0028 , A61K9/0048 , A61K47/10 , A61K47/36

摘要： A photo-responsive delivery system useful to deliver a compound to a target site is provided. The system includes a physiologically compatible matrix crosslinked with a photo-responsive matrix cross-linking agent. A method of making the delivery system and a method of delivering a compound to a target site using the system are also provided.

摘要翻译： 提供了一种可用于将化合物递送至目标部位的光敏感递送系统。该系统包括与光敏矩阵交联剂交联的生理上相容的基质。还提供了一种制备递送系统的方法和使用该系统将化合物递送到目标部位的方法。

9.

发明申请
METHOD OF IMMOBILIZING MEMBRANE-ASSOCIATED MOLECULES 审中-公开
标题翻译：固定膜相关分子的方法

公开(公告)号：US20080261825A1

公开(公告)日：2008-10-23

申请号：US12163097

申请日：2008-06-27

申请人： John D. Brennan , Michael A. Brook , Travis Besanger

发明人： John D. Brennan , Michael A. Brook , Travis Besanger

IPC分类号： C40B30/04 , C40B50/14 , C40B40/10 , G01N30/02 , C40B30/00

CPC分类号： G01N33/5432 , G01N33/552 , G01N33/6872 , G01N2333/726

摘要： The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.

摘要翻译： 本发明涉及将膜相关分子固定在溶胶 - 凝胶基质内的方法。膜相关分子嵌入脂质体的双层。当分子 - 脂质体组装体固定在蛋白质中并且由多元醇硅烷前体或硅酸钠衍生的与膜相容的溶胶凝胶固定时，分子 - 脂质体组件保持功能完整。大孔二氧化硅中截留的膜相关分子的活性和稳定性显着改善。