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公开(公告)号：US20080261825A1
公开(公告)日：2008-10-23
申请号：US12163097
申请日：2008-06-27
CPC分类号： G01N33/5432 , G01N33/552 , G01N33/6872 , G01N2333/726
摘要： The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.
摘要翻译： 本发明涉及将膜相关分子固定在溶胶 - 凝胶基质内的方法。 膜相关分子嵌入脂质体的双层。 当分子 - 脂质体组装体固定在蛋白质中并且由多元醇硅烷前体或硅酸钠衍生的与膜相容的溶胶凝胶固定时，分子 - 脂质体组件保持功能完整。 大孔二氧化硅中截留的膜相关分子的活性和稳定性显着改善。
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2.发明申请METHODS AND COMPOUNDS FOR FORMING MONOLITHIC TITANIA, OPTIONALLY BIOMOLECULE DOPED, WITH CONTROLLED MORPHOLOGY USING BIOCOMPATIBLE SOL-GEL PROCESSES 审中-公开用生物易溶性凝胶法制备单晶钛铁矿，选择性生物分子，控制形态的方法和化合物公开(公告)号：US20100239493A1
公开(公告)日：2010-09-23
申请号：US12442434
申请日：2007-09-24
申请人： Yunyu Yi , Michael A. Brook , John D. Brennan , Yang Chen
发明人： Yunyu Yi , Michael A. Brook , John D. Brennan , Yang Chen
IPC分类号： C01G23/047 , C07F7/28 , C07H23/00
CPC分类号： B01J20/0211 , B01J20/06 , B01J20/282 , B82Y30/00 , C01G23/047 , C01G23/053 , C01P2002/52 , C01P2002/72 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/62 , C01P2006/64 , C01P2006/82 , C07F7/003 , C12N9/104 , C12N11/14 , C12Y203/02002
摘要： The present invention includes polyol modified titanium compounds, their preparation and use in methods to make biomolecule compatible monolithic titania. The invention also includes the use of the biomolecule compatible monolithic titania in bioanalytic applications, for example in biosensors, chromatographic columns, microarrays and bioaffinity columns.
摘要翻译： 本发明包括多元醇改性的钛化合物，它们的制备和用于制备生物分子相容的整体式二氧化钛的方法。 本发明还包括在生物分析应用中使用生物分子相容的整体二氧化钛，例如在生物传感器，色谱柱，微阵列和生物亲和柱中。
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3.发明授权Protein compatible methods and compounds for controlling the morphology and shrinkage of silica derived from polyol-modified silanes 有权用于控制衍生自多元醇改性硅烷的二氧化硅的形态和收缩的蛋白质相容方法和化合物公开(公告)号：US07375168B2
公开(公告)日：2008-05-20
申请号：US10814123
申请日：2004-04-01
申请人： Zheng Zhang , Yang Chen , Jorge Cruz-Aguado , Richard J. Hodgson , Dina Tleugabulova , John D. Brennan , Michael A. Brook
发明人： Zheng Zhang , Yang Chen , Jorge Cruz-Aguado , Richard J. Hodgson , Dina Tleugabulova , John D. Brennan , Michael A. Brook
IPC分类号： C08L83/02
CPC分类号： B01J20/28085 , A61K47/52 , B01D15/3804 , B01J20/103 , B01J20/28014 , B01J20/28042 , B01J20/28083 , B01J20/28092 , B01J20/283 , B01J20/286 , B01J2220/82 , C01B33/12 , C01B33/16 , C04B35/14 , C04B35/624 , C04B35/62605 , C04B35/62655 , C04B35/632 , C04B35/634 , C04B38/0045 , C04B2235/441 , C04B2235/77 , G01N15/088 , G01N2030/528 , C04B38/0064
摘要： Siliceous materials were prepared by adding one or more additives, including one or more water soluble polymers, and derivatives thereof, as well as trifunctional silanes, to sols containing tetraalkoxysilanes derived from polyols. The polymers facilitate phase separation of the growing silica gel matrix, leading to high surface area self-supporting silica gels with cure occurring at ambient temperatures. The materials also show a significant reduction in shrinkage properties and significant protein stabilization abilities.
摘要翻译： 通过向包含衍生自多元醇的四烷氧基硅烷的溶胶中加入一种或多种添加剂，包括一种或多种水溶性聚合物及其衍生物以及三官能硅烷来制备硅质材料。 聚合物促进生长硅胶基质的相分离，导致高表面积自支撑硅胶，其固化在环境温度下发生。 这些材料还显示收缩性能和显着的蛋白质稳定化能力的显着降低。
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公开(公告)号：US07582214B2
公开(公告)日：2009-09-01
申请号：US11425238
申请日：2006-06-20
申请人： Michael A. Brook , John D. Brennan , Hanjiang Dong
发明人： Michael A. Brook , John D. Brennan , Hanjiang Dong
CPC分类号： B01J20/28042 , B01J20/283 , B01J20/285 , B01J2220/82 , C01P2006/12 , C01P2006/14 , C01P2006/17
摘要： The present invention relates to a two-step method of preparing methylsilsequixane (MSQ) materials suitable for chromatographic applications comprising treating a MSQ precursor with a suitable acid followed by treatment with a suitable base under conditions to form a MSQ monolith suitable for chromatographic applications.
摘要翻译： 本发明涉及制备适用于色谱应用的甲基硅基四烷（MSQ）材料的两步法，包括用合适的酸处理MSQ前体，然后在合适的碱处理条件下形成适用于色谱应用的MSQ整料。
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公开(公告)号：US08648211B2
公开(公告)日：2014-02-11
申请号：US13392568
申请日：2010-08-27
申请人： Michael A. Brook , Yongxin Wang , Yang Chen
发明人： Michael A. Brook , Yongxin Wang , Yang Chen
CPC分类号： C08J7/12 , C07F7/0838 , C08G77/045 , C08G77/12 , C08G77/20 , C08G77/46 , C09D183/12
摘要： The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.
摘要翻译： 本公开内容描述了式（I）的化合物，其中m为1至6，n为6至10，并且R 1为直链或支链硅氧烷，它们用于改性疏水性底物表面以使底物超亲水性和表面 改性基质。
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公开(公告)号：US20090028946A1
公开(公告)日：2009-01-29
申请号：US12149940
申请日：2008-05-09
申请人： Heather Sheardown , Michael A. Brook , Laura Wells
发明人： Heather Sheardown , Michael A. Brook , Laura Wells
IPC分类号： A61K9/10
CPC分类号： A61K41/0028 , A61K9/0048 , A61K47/10 , A61K47/36
摘要： A photo-responsive delivery system useful to deliver a compound to a target site is provided. The system includes a physiologically compatible matrix crosslinked with a photo-responsive matrix cross-linking agent. A method of making the delivery system and a method of delivering a compound to a target site using the system are also provided.
摘要翻译： 提供了一种可用于将化合物递送至目标部位的光敏感递送系统。 该系统包括与光敏矩阵交联剂交联的生理上相容的基质。 还提供了一种制备递送系统的方法和使用该系统将化合物递送到目标部位的方法。
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公开(公告)号：US20110077365A1
公开(公告)日：2011-03-31
申请号：US12648395
申请日：2009-12-29
申请人： Gilbert Yu , Ferdinand Gonzaga , Michael A. Brook
发明人： Gilbert Yu , Ferdinand Gonzaga , Michael A. Brook
IPC分类号： C08G77/388 , C07F7/10 , C08G77/26
CPC分类号： C07F7/0889 , C07F7/0838 , C08G77/20 , C08G77/26 , C08G77/38
摘要： The disclosure includes methods for preparing organosilicon-containing 1,2,3-triazoles by reacting an organosilicon containing azide with an alkyne compound or an organosilicon containing alkyne with an azide compound under thermal reaction conditions.
摘要翻译： 本公开内容包括通过在热反应条件下使含有叠氮化物的有机硅与含炔化合物或含炔烃的有机硅与叠氮化合物反应制备含有有机硅的1,2,3-三唑的方法。
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公开(公告)号：US20100173347A1
公开(公告)日：2010-07-08
申请号：US12593719
申请日：2008-04-02
申请人： Michael A. Brook , Yingfu Li , Ferdinand Gonzaga , Weian Zhao , Monsur M. Ali , Sergio D. Aguirre
发明人： Michael A. Brook , Yingfu Li , Ferdinand Gonzaga , Weian Zhao , Monsur M. Ali , Sergio D. Aguirre
CPC分类号： G01N33/532 , B22F1/0022 , B22F1/0062 , B22F9/24 , B82Y5/00 , B82Y30/00 , G01N33/585
摘要： The present disclosure relates to water-soluble stable gold nanoparticles (AuNPs) and methods for making the same. The present disclosure also includes the use of AuNPs, for example, in biological, medical and environmental assays for the detection of analytes, as well as biological and medical imaging.
摘要翻译： 本公开涉及水溶性稳定金纳米颗粒（AuNP）及其制备方法。 本公开还包括使用AuNP，例如在用于检测分析物的生物，医学和环境测定中，以及生物和医学成像。
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9.发明授权Microparticle delivery system with a functionalized silicone bonded to the matrix 失效具有键合到基质上的官能化硅氧烷的微粒输送系统
公开(公告)号：US5571531A
公开(公告)日：1996-11-05
申请号：US245646
申请日：1994-05-18
申请人： Mark R. McDermott , Michael A. Brook , Philippa L. Heritage , Brian J. Underdown , Lesley M. Loomes , Jianxiong Jiang
发明人： Mark R. McDermott , Michael A. Brook , Philippa L. Heritage , Brian J. Underdown , Lesley M. Loomes , Jianxiong Jiang
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K9/58 , A61K39/00 , C07K17/10 , C12N11/10 , A61K9/56 , A61K9/14 , A01N25/34
CPC分类号： C12N11/10 , A61K9/167 , A61K9/5031 , C07K17/10 , A61K39/00
摘要： A particulate carrier for an agent comprising a solid core of a polysaccharide and a proteinaceous material and an organometallic polymer bonded to the core is provided. The agent has a biological activity, such as immunogenicity, and may comprise the proteinaceous material or be a separate component of the core. Polysaccharide cores include dextran, starch, cellulose and derivatives thereof and the organometallic polymer includes silicones including substituted silicones. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral administration to produce immune responses, including antibody responses.
摘要翻译： 提供了一种用于包含多糖的固体核和蛋白质物质和与芯结合的有机金属聚合物的试剂的颗粒载体。 该试剂具有生物活性，例如免疫原性，并且可以包含蛋白质物质或者是核心的单独成分。 多糖核心包括葡聚糖，淀粉，纤维素及其衍生物，有机金属聚合物包括含有取代的有机硅的硅氧烷。 颗粒载体可用于通过粘膜或肠胃外给药将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。
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公开(公告)号：US20120226001A1
公开(公告)日：2012-09-06
申请号：US13392568
申请日：2010-08-27
申请人： Michael A. Brook , Yongxin Wang , Wang Chen
发明人： Michael A. Brook , Yongxin Wang , Wang Chen
CPC分类号： C08J7/12 , C07F7/0838 , C08G77/045 , C08G77/12 , C08G77/20 , C08G77/46 , C09D183/12
摘要： The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.
摘要翻译： 本公开内容描述了式（I）的化合物，其中m为1至6，n为6至10，并且R 1为直链或支链硅氧烷，它们用于改性疏水性底物表面以使底物超亲水性和表面 改性基质。
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