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37 条记录 (耗时 0.029 秒)

    Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
    3.
    发明授权
    Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones 失效
    1-吡咯烷-2-酮的精神病学1-（2-嘧啶基）哌嗪基衍生物

    公开(公告)号：US4668687A

    公开(公告)日：1987-05-26

    申请号：US799670

    申请日：1985-11-19

    申请人： Joseph P. Yevich ,  Ronald J. Mattson

    发明人： Joseph P. Yevich ,  Ronald J. Mattson

    IPC分类号： C07D239/42 ,  C07D403/12 ,  A61K31/505 ,  C07D403/04

    CPC分类号： C07D239/42 ,  C07D403/12

    摘要： A series of nootropic compounds of the following formula: ##STR1## and its pharmaceutically acceptable acid addition salts, wherein: R.sup.2 is hydrogen, lower alkyl, aryl which is optimally substituted, or hetaryl;R.sup.7 is hydrogen or is combined with R.sup.9 as a fused benzo-ring;R.sup.8 is hydrogen or lower alkyl; andR.sup.9 is lower alkyl, or R.sup.9 can be combined with R.sup.8 to give a 2-pyrrolidinone, a phthalimide, or isoindolone ring system.Pharmacological testing demonstrates that the series possesses cognition and memory enhancing actions and/or mild CNS simulation.

    摘要翻译： 一系列具有下式的引发性化合物：其中：R2是氢，低级烷基，被最佳取代的芳基或杂芳基; R7是氢或与R 9一起作为稠合的苯并环; R8是氢或低级烷基; 并且R 9为低级烷基，或R 9可与R 8结合，得到2-吡咯烷酮，邻苯二甲酰亚胺或异吲哚酮环系。 药理测试表明该系列具有认知和记忆增强作用和/或轻度CNS模拟。

    Cerebral function enhancing diazinylpiperidine derivatives
    8.
    发明授权
    Cerebral function enhancing diazinylpiperidine derivatives 失效
    脑功能增强二氮嗪基哌啶衍生物

    公开(公告)号：US4826843A

    公开(公告)日：1989-05-02

    申请号：US90985

    申请日：1987-08-28

    申请人： Ronald J. Mattson ,  Joseph P. Yevich ,  Michael S. Eison

    发明人： Ronald J. Mattson ,  Joseph P. Yevich ,  Michael S. Eison

    IPC分类号： C07D401/14 ,  A61K31/445 ,  A61K31/50 ,  A61K31/505

    CPC分类号： C07D401/14

    摘要： A series of diazinylpiperidine compounds of Formula I ##STR1## wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R.sup.1 is hydrogen or lower alkyl; and Z is an R.sup.2, R.sup.3 -disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacologic and neuroanatomical testing demonstrates that compounds of the series act to enhance cerebral function in mammals, particularly when there is a deficit in normal cerebral functioning. Specific pharmacologic test results indicate that compounds of Formula I possess cognition and memory enhancing activity.

    摘要翻译： 一系列式I的二嗪基哌啶化合物其中X是乙烯链或1,2-苯并环; Y是羰基或亚甲基; R1是氢或低级烷基; 并且Z是选自哒嗪，嘧啶和吡嗪环体系的R2，R3-二取代的二嗪基环。 药理学和神经解剖学测试表明，该系列化合物可以增强哺乳动物的脑功能，特别是在正常大脑功能发生逆转时。 具体的药理学实验结果表明，式I化合物具有认知和记忆增强活性。