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公开(公告)号:US08802390B2
公开(公告)日:2014-08-12
申请号:US13353001
申请日:2012-01-18
申请人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号: C12Q1/37
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移过程的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号:US20120012472A1
公开(公告)日:2012-01-19
申请号:US13187142
申请日:2011-07-20
申请人: Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
发明人: Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
CPC分类号: G01N27/327 , C07F15/002 , C12Q1/003 , G01N33/54353 , G01N33/5438 , Y10T29/49117 , Y10T29/49204
摘要: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
摘要翻译: 本发明涉及可用于合成标记蛋白质,核酸和用于电极修饰的二取代联吡啶锇络合物的新组合物。
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公开(公告)号:US20090253149A1
公开(公告)日:2009-10-08
申请号:US12253875
申请日:2008-10-17
申请人: Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号: G01N33/573 , B32B9/00
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移过程的核重组能量λ检测分析物的新型组合物和方法。
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公开(公告)号:US08734631B2
公开(公告)日:2014-05-27
申请号:US12253875
申请日:2008-10-17
申请人: Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Michael Ahrens , Paul A. Bertin , Amanda Eckermann , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号: C25D1/00
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移过程的核重组能量λ检测分析物的新型组合物和方法。
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公开(公告)号:US08951400B2
公开(公告)日:2015-02-10
申请号:US13187142
申请日:2011-07-20
申请人: Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
发明人: Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
IPC分类号: C25D1/00 , C12Q1/00 , G01N33/543
CPC分类号: G01N27/327 , C07F15/002 , C12Q1/003 , G01N33/54353 , G01N33/5438 , Y10T29/49117 , Y10T29/49204
摘要: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
摘要翻译: 本发明涉及可用于合成标记蛋白质,核酸和用于电极修饰的二取代联吡啶锇络合物的新组合物。
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公开(公告)号:US20120156709A1
公开(公告)日:2012-06-21
申请号:US13353001
申请日:2012-01-18
申请人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号: G01N27/00
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移过程的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号:US20100003710A1
公开(公告)日:2010-01-07
申请号:US12253828
申请日:2008-10-17
申请人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移方法的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号:US5880149A
公开(公告)日:1999-03-09
申请号:US721872
申请日:1996-09-27
IPC分类号: A61K31/555 , A61K31/00 , A61K31/665 , A61K31/67 , A61K31/675 , A61K31/69 , A61P29/00 , A61P43/00 , C07C251/24 , C07F1/00 , C07F1/08 , C07F1/12 , C07F15/00 , C07F15/04 , A61K31/28 , C07H23/00
CPC分类号: C07F1/005 , C07C251/24 , C07F15/0066 , C07F15/0093 , C07F15/045
摘要: The invention relates to metal complexes used to bind proteins and enzymes.
摘要翻译: 本发明涉及用于结合蛋白质和酶的金属络合物。
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9.
公开(公告)号:US06780856B2
公开(公告)日:2004-08-24
申请号:US09828499
申请日:2001-04-06
申请人: Thomas J. Meade , Ofer Blum , Harry B. Gray
发明人: Thomas J. Meade , Ofer Blum , Harry B. Gray
IPC分类号: A61K3133
CPC分类号: C07F15/06 , C07F15/065
摘要: The invention relates to methods of stabilizing in an aqueous medium cobalt (III) Schiff base complexes and stabilized cobalt (III) Schiff base compounds therefrom.
摘要翻译: 本发明涉及在含水介质中稳定钴(III)席夫碱络合物和稳定的(III)席夫碱化合物的方法。
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公开(公告)号:US6008190A
公开(公告)日:1999-12-28
申请号:US570761
申请日:1995-12-12
IPC分类号: C12N9/99 , A61K31/295 , A61K31/555 , A61K38/00 , A61P43/00 , C07C251/10 , C07C251/12 , C07C251/16 , C07F15/06 , C07H21/00 , A61K31/70 , A61K38/02
CPC分类号: C07H21/00 , C07C251/12 , C07C251/16 , C07F15/065 , Y10S424/06
摘要: The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.
摘要翻译: 本发明涉及具有通式结构的新型钴化合物,其中Co是Co(II)或Co(III),并且每个R基团选自氢,烷基,亲水有机酸,烷基胺, 胺,烷基醇,醇,多肽或核酸。 本发明还涉及使用这些化合物降低蛋白质,特别是酶和含锌指蛋白质的生物学活性的方法。
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