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公开(公告)号：US08715657B2
公开(公告)日：2014-05-06
申请号：US13265346
申请日：2010-03-29
申请人： Michael Bardroff , Jose M. Carballido Herrera , Daniela Della Ducata , Christoph Heusser , Ute Jaeger , Christoph Schwaerzler
发明人： Michael Bardroff , Jose M. Carballido Herrera , Daniela Della Ducata , Christoph Heusser , Ute Jaeger , Christoph Schwaerzler
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/2866 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
摘要翻译： 本发明涉及特异性结合IL12R＆lt; 1，异源二聚体IL12受体（连同IL12R＆bgr 2链）的非信号转导链以及IL23受体（连同IL23Rα链）的抗体。 本发明更具体地涉及能够抑制IL12 / IL18诱导的T细胞的IFNγ产生的IL12和IL23受体拮抗剂的特异性抗体，以及用于所述抗体治疗可通过抑制IFNγ产生来治疗的病理学障碍的组合物和方法， 作为类风湿性关节炎，牛皮癣或炎性肠病或其他自身免疫性和炎症性疾病。
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公开(公告)号：US20120034231A1
公开(公告)日：2012-02-09
申请号：US13265346
申请日：2010-03-29
申请人： Michael Bardroff , José M. Carballido Herrera , Daniela Della Ducata , Christoph Heusser , Ute Jaeger , Christoph Schwaerzler
发明人： Michael Bardroff , José M. Carballido Herrera , Daniela Della Ducata , Christoph Heusser , Ute Jaeger , Christoph Schwaerzler
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , A61P29/00 , C12N1/19 , C12N5/12 , C12P21/00 , A61P19/02 , A61P17/06 , C07K16/28 , C12N1/15
CPC分类号： C07K16/244 , A61K2039/505 , C07K16/2866 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
摘要翻译： 本发明涉及特异性结合IL12R＆lt; 1，异源二聚体IL12受体（连同IL12R＆bgr 2链）的非信号转导链以及IL23受体（连同IL23Rα链）的抗体。 本发明更具体地涉及能够抑制IL12 / IL18诱导的T细胞的IFNγ产生的IL12和IL23受体拮抗剂的特异性抗体，以及用于所述抗体治疗可通过抑制IFNγ产生来治疗的病理学障碍的组合物和方法， 作为类风湿性关节炎，牛皮癣或炎性肠病或其他自身免疫性和炎症性疾病。
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公开(公告)号：US08673306B2
公开(公告)日：2014-03-18
申请号：US12160875
申请日：2007-01-12
申请人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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公开(公告)号：US20120225478A1
公开(公告)日：2012-09-06
申请号：US13472781
申请日：2012-05-16
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。
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公开(公告)号：US08216577B2
公开(公告)日：2012-07-10
申请号：US12462119
申请日：2009-07-28
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译： 本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含 如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。
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公开(公告)号：US20090068109A1
公开(公告)日：2009-03-12
申请号：US11942126
申请日：2007-11-19
申请人： Anuk Das , Raymond Sweet , Ping Tsui , Michael Bardroff
发明人： Anuk Das , Raymond Sweet , Ping Tsui , Michael Bardroff
CPC分类号： C07K16/24 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to at least one novel anti-MCP-1 antibody, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的抗MCP-1抗体，包括编码至少一种抗MCP-1抗体，MCP-1，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 包括治疗组合物，方法和装置。
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公开(公告)号：US08420787B2
公开(公告)日：2013-04-16
申请号：US12280674
申请日：2007-02-21
IPC分类号： C12P21/08
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to human thymic stromal lymphopoietin (hTSLP) antibodies and especially those which neutralize hTSLP activity. It further relates to methods for using anti-hTSLP antibody molecules in diagnosis or treatment of hTSLP related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease, and Hodgkin's lymphoma.
摘要翻译： 本发明涉及人类胸腺基质淋巴细胞生成素（hTSLP）抗体，特别是中和hTSLP活性的那些。 它还涉及在诊断或治疗hTSLP相关疾病如哮喘，特应性皮炎，过敏性鼻炎，纤维化性肠炎和霍奇金淋巴瘤中使用抗hTSLP抗体分子的方法。
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公开(公告)号：US20120023600A1
公开(公告)日：2012-01-26
申请号：US12160875
申请日：2007-01-12
申请人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine Shulok , Feng Cong , Mark Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： C07K16/18 , A01K67/027 , A61P35/00 , A61P17/14 , A61P3/04 , A61P21/00 , A61P25/28 , A61P29/00 , A61K39/395 , A61P3/10
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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公开(公告)号：US09296813B2
公开(公告)日：2016-03-29
申请号：US14178892
申请日：2014-02-12
申请人： Janine R. Shulok , Feng Cong , Mark C. Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine R. Shulok , Feng Cong , Mark C. Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： A61K39/395 , C07K16/22 , C07K16/18 , A61K31/675 , A61K45/06 , A61K39/00
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译： 提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。
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公开(公告)号：US07794719B2
公开(公告)日：2010-09-14
申请号：US10505313
申请日：2003-02-20
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译： 本发明涉及能够特异性识别R-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含氨基酸 酸序列VHHQKLVFFAEDVG，如SEQ ID NO：2所示或其片段。 此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。 此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。
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