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    Therapeutic and diagnostic methods using soluble T cell surface molecules
    3.
    发明授权
    Therapeutic and diagnostic methods using soluble T cell surface molecules 失效
    使用可溶性T细胞表面分子的治疗和诊断方法

    公开(公告)号：US5292636A

    公开(公告)日：1994-03-08

    申请号：US434398

    申请日：1989-11-09

    申请人： Patrick C. Kung ,  Stephen H. Ip ,  Michael C. Brown ,  Linda A. MacKeen

    发明人： Patrick C. Kung ,  Stephen H. Ip ,  Michael C. Brown ,  Linda A. MacKeen

    IPC分类号： C07K16/28 ,  G01N33/564 ,  G01N33/566 ,  G01N33/569 ,  G01N33/571 ,  G01N33/574 ,  G01N33/68 ,  G01N33/543 ,  G01N33/577

    CPC分类号： C07K16/2812 ,  C07K16/2815 ,  G01N33/564 ,  G01N33/566 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/571 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57488 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2333/71 ,  G01N2333/715 ,  G01N2800/102 ,  G01N2800/245 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/813

    摘要： The present invention is directed to the measurement of soluble T cell growth factor receptors, soluble T cell differentiation antigens, or related soluble molecules or fragments thereof, and the use of such measurements in the diagnosis, staging, and therapy of diseases and disorders. Specific embodiments involve the diagnosis and monitoring of therapy using absolute values of such soluble molecules. Further embodiments involve detecting a change in the levels of such soluble molecules, in the diagnosis and therapy of diseases and disorders. In specific embodiments, measurements of interleukin-2 receptor levels can be made to detect lung cancer, or to stage squamous cell lung carcinoma. In other embodiments, detection of increases in both soluble IL2R and creatinine in the body fluid of a transplant patient can be used to differentially diagnose renal allograft rejection from infection. The invention is also directed to methods for measurement of soluble CD4 antigens, which measurements can be used, in a specific embodiment, to diagnose a state of immune activation, to diagnose rheumatoid arthritis, to monitor therapeutic efficacy (e.g. of AIDS treatments), or to stage adult T cell leukemia in a patient. In another aspect, the invention relates to the detection, staging, and monitoring of therapy of diseases and disorders by measuring a plurality of soluble T cell markers.

    摘要翻译： 本发明涉及可溶性T细胞生长因子受体，可溶性T细胞分化抗原或相关的可溶性分子或其片段的测量，以及在疾病和病症的诊断，分期和治疗中使用这些测量。 具体实施方案涉及使用这种可溶性分子的绝对值来诊断和监测治疗。 进一步的实施方案涉及在疾病和病症的诊断和治疗中检测这些可溶性分子的水平的变化。 在具体实施方案中，可以测量白细胞介素-2受体水平以检测肺癌或鳞状细胞肺癌。 在其它实施方案中，检测移植患者的体液中可溶性IL2R和肌酐的增加可用于差异性诊断感染的肾同种异体移植排斥反应。 本发明还涉及用于测量可溶性CD4抗原的方法，在具体实施方案中可以使用测量来诊断免疫激活的状态，诊断类风湿性关节炎，以监测治疗功效（例如AIDS治疗）或 在患者中分期成年T细胞白血病。 另一方面，本发明涉及通过测量多种可溶性T细胞标记来检测，分期和监测疾病和病症的治疗。

    Dispensing/vending machine and method with lockable, portable dispensing chutes
    5.
    发明授权
    Dispensing/vending machine and method with lockable, portable dispensing chutes 失效
    分配/自动售货机和方法，具有可锁定，便携式分配滑槽

    公开(公告)号：US5476190A

    公开(公告)日：1995-12-19

    申请号：US310932

    申请日：1994-09-22

    申请人： Herbert L. Herrmann ,  Jeffrey A. Belka ,  Michael C. Brown

    发明人： Herbert L. Herrmann ,  Jeffrey A. Belka ,  Michael C. Brown

    IPC分类号： G07F11/22 ,  G07F17/42 ,  B65H1/00

    CPC分类号： G07F17/42 ,  G07F11/22

    摘要： A vending machine for dispensing relatively flat, thin articles, and particularly for dispensing valuable articles such as debit cards and tickets. The articles to be dispensed are stored in removable chutes. Lockable covers are provided for the chutes so as to provide safe transportation containers for the valuable articles. Automatic device is provided for displacing the covers upon insertion of the chutes into the dispensing mechanism so as to prepare the mechanism for immediately dispensing the articles and eliminating the need to totally remove the covers during usage.

    摘要翻译： 一种自动售货机，用于分配相对平坦，薄的制品，特别是用于分发有价值的物品，例如借记卡和票据。 要分配的物品存储在可拆卸的滑槽中。 为滑槽提供可锁定盖，以便为有价值物品提供安全的运输集装箱。 提供自动装置，用于在将滑槽插入分配机构中时移动盖，以便准备用于立即分配物品的机构，并且消除在使用期间完全去除盖子的需要。

    Cell free T cell antigen receptor beta chain and its clinical utilities
    6.
    发明授权
    Cell free T cell antigen receptor beta chain and its clinical utilities 失效
    无细胞T细胞抗原受体β链及其临床应用

    公开(公告)号：US5436319A

    公开(公告)日：1995-07-25

    申请号：US312167

    申请日：1994-09-26

    申请人： Patrick C. Kung ,  Stephen H. Ip ,  Michael C. Brown

    发明人： Patrick C. Kung ,  Stephen H. Ip ,  Michael C. Brown

    IPC分类号： A61K38/17 ,  A61K39/00 ,  C07K14/725 ,  C07K16/28

    CPC分类号： C07K16/2809 ,  C07K14/7051 ,  G01N33/56972 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/7051 ,  Y10S530/83

    摘要： Cell-free or released T cell antigen receptors, immunoassays which allow the detection of the released T cell antigen receptor in cell culture supernatants, cell lysates, and biological fluids, as well as diagnostic and therapeutic compositions and methods for monitoring and treating certain diseases or disorders which elicit or involve a T cell response are described. The released T cell antigen receptors described herein differ from the cell membrane bound antigen receptors and appear to exist in a variety of forms, some of which may be complexed with other T cell determinants such as the T3 antigen. Despite the size heterogeneity of the released T cell antigen receptors or receptor/complexes, these may be reliably identified using anti-receptor antibodies, including, but not limited to, anti-major framework, anti-minor frarmework and anti-clonotypic antibodies which define particular epitopes of the released T cell receptor or receptor/complex. The immunoassays described herein may be used to test for the presence of the released receptor or receptor/complex in biological samples and may be used to diagnose or monitor patients with disorders or diseases that elicit or involve T cell response who exhibit elevated serum level of the receptor or receptor/complex. In addition, the cell free T cell antigen receptors themselves may be used diagnostically and/or therapeutically for diseases or conditions that are not easily addressed using immunoglobulins.

    摘要翻译： 无细胞或释放的T细胞抗原受体，允许检测细胞培养物上清液，细胞裂解物和生物流体中释放的T细胞抗原受体的免疫测定，以及用于监测和治疗某些疾病的诊断和治疗组合物和方法， 描述引起或涉及T细胞应答的病症。 本文所述释放的T细胞抗原受体不同于细胞膜结合的抗原受体，并且似乎以多种形式存在，其中一些可与其它T细胞决定簇如T3抗原复合。 尽管释放的T细胞抗原受体或受体/复合物的大小异质性，但可以使用抗受体抗体可靠地鉴定这些抗体，所述抗受体抗体包括但不限于抗主要框架，抗小细胞体系和抗克隆型抗体 释放的T细胞受体或受体/复合物的特异性表位。 本文描述的免疫测定可用于测试生物样品中释放的受体或受体/复合物的存在，并且可用于诊断或监测引起或涉及T细胞应答的患者，所述疾病或疾病表现出升高的血清水平 受体或受体/复合物。 此外，无细胞的T细胞抗原受体本身可以在诊断和/或治疗上用于使用免疫球蛋白不容易解决的疾病或病症。

    Methods and devices for securing suture to tissue
    9.
    发明授权
    Methods and devices for securing suture to tissue 有权
    用于将缝合线固定到组织的方法和装置

    公开(公告)号：US09314239B2

    公开(公告)日：2016-04-19

    申请号：US13478537

    申请日：2012-05-23

    申请人： Michael C. Brown

    发明人： Michael C. Brown

    IPC分类号： A61B17/04 ,  A61F2/08

    CPC分类号： A61B17/0401 ,  A61B2017/044 ,  A61F2002/0852 ,  A61F2002/087

    摘要： Methods and devices are provided for securing suture to tissue. In one exemplary embodiment, the implant can include an intermediate portion, a first radially expandable portion extending from the intermediate portion, and a second radially expandable portion extending from the intermediate portion. The implant can be configured to be inserted through a delivery device in a first configuration and deployed into a hole formed in tissue in a second configuration such that the intermediate portion is positioned within the hole. A suture can be inserted through a passageway of the intermediate portion positioned within the hole, and the suture can be tensioned to secure the tissue to bone.

    摘要翻译： 提供了用于将缝合线固定到组织上的方法和装置。 在一个示例性实施例中，植入物可以包括中间部分，从中间部分延伸的第一可径向扩张部分和从中间部分延伸的第二可径向扩张部分。 植入物可以构造成以第一构型插入通过输送装置，并且以第二构造部署到组织中形成的孔中，使得中间部分位于孔内。 缝合线可以穿过定位在孔内的中间部分的通道插入，缝合线可以被张紧以将组织固定在骨头上。

    Distal detachment mechanisms for vascular devices
    10.
    发明授权
    Distal detachment mechanisms for vascular devices 有权
    血管装置的远端分离机制

    公开(公告)号：US08734500B2

    公开(公告)日：2014-05-27

    申请号：US13246343

    申请日：2011-09-27

    申请人： Thomas Boden ,  Michael C. Brown

    发明人： Thomas Boden ,  Michael C. Brown

    IPC分类号： A61F2/82

    CPC分类号： A61F2/966 ,  A61F2002/9505 ,  A61F2002/9534 ,  A61F2002/9665 ,  A61F2230/0091

    摘要： A system for delivering an expandable implant into the vasculature of a patient, including an elongated core element having a proximal end accessible exterior to the patient and a distal end including at least one feature for engaging a proximal portion of the implant in a collapsed state. The system further includes an expansion limiter having an inner diameter and a length sufficient to cover the proximal portion of the implant and to retain the proximal portion in the collapsed state, and at least one elongated member having a distal end connected to the expansion limiter and a proximal end accessible exterior to the patient to enable proximal movement of the expansion limiter to release the implant.

    摘要翻译： 一种用于将可扩张植入物递送到患者的脉管系统中的系统，包括细长的芯元件，其具有可触及病人外部的近端，以及包括至少一个特征的远端，用于在塌缩状态下接合植入物的近端部分。 所述系统还包括膨胀限制器，其具有足够的内径和长度以覆盖植入物的近端部分并且将近端部分保持在折叠状态，以及至少一个细长构件，其远端连接到膨胀限制器， 近端可触及患者的外部，以使扩张限制器近端移动以释放植入物。