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    NITRIC OXIDE DONORS FOR TREATMENT OF DISEASE AND INJURY
    2.
    发明申请
    NITRIC OXIDE DONORS FOR TREATMENT OF DISEASE AND INJURY 审中-公开
    用于治疗疾病和伤害的硝酸氧化物

    公开(公告)号：US20120009152A1

    公开(公告)日：2012-01-12

    申请号：US12889873

    申请日：2010-09-24

    申请人： Michael Chopp

    发明人： Michael Chopp

    IPC分类号： A61K31/497 ,  A61K35/00 ,  A61P25/00 ,  C07D487/04

    CPC分类号： A61K31/519 ,  A61K31/00

    摘要： A method of promoting neurogenesis by administering a therapeutic amount of a phosphodiesterase inhibitor compound to a patient in need of neurogenesis promotion. A compound for providing neurogenesis having an effective amount of a phosphodiesterase inhibitor sufficient to promote neurogenesis. A phosphodiesterase inhibitor for promoting neurogenesis. A method of augmenting the production of brain cells and facilitating cellular structural and receptor changes by administering an effective amount of a phosphodiesterase inhibitor compound to a site in need of augmentation. A method of increasing both neurological and cognitive function by administering an effective amount of a phosphodiesterase inhibitor compound to a patient.

    摘要翻译： 一种通过向需要神经发生促进的患者施用治疗量的磷酸二酯酶抑制剂化合物来促进神经发生的方法。 一种用于提供神经发生的化合物，其具有足以促进神经发生的有效量的磷酸二酯酶抑制剂。 用于促进神经发生的磷酸二酯酶抑制剂。 通过向需要增加的部位施用有效量的磷酸二酯酶抑制剂化合物来增加脑细胞的产生并促进细胞结构和受体变化的方法。 通过向患者施用有效量的磷酸二酯酶抑制剂化合物来增加神经学和认知功能的方法。

    BONE MARROW TRANSPLANTATION FOR TREATMENT OF STROKE
    4.
    发明申请
    BONE MARROW TRANSPLANTATION FOR TREATMENT OF STROKE 审中-公开
    骨髓移植用于治疗STROKE

    公开(公告)号：US20090162327A1

    公开(公告)日：2009-06-25

    申请号：US12249687

    申请日：2008-10-10

    申请人： Yi Li ,  Michael Chopp

    发明人： Yi Li ,  Michael Chopp

    IPC分类号： A61K35/12

    CPC分类号： A61K35/28

    摘要： There is provided a treatment for patients suffering from neurodegenerative disease or neural injury including the steps of transplanting cultured bone marrow cells into the spinal cord or brain or injecting intravascularly bone marrow cells of a patient in need. Also provided is a method of activating the differentiation of neural cells in an injured brain including the steps of transplanting bone marrow cells adjacent to the injured brain cells and activating the endogenous central nervous system stem cells to differentiate into neurons. A method of treating injured brain or spinal cord cells is also provided including the steps of transplanting bone marrow cells near the injured brain cells and generating new neurons at the location of transplantation. A method of treating injured brain or spinal cord cells with a composite of MSCs and neurospheres.

    摘要翻译： 为患有神经变性疾病或神经损伤的患者提供治疗，包括将培养的骨髓细胞移植到脊髓或脑中或注射需要的患者的血管内骨髓细胞的步骤。 还提供了激活受损脑中神经细胞分化的方法，包括移植邻近受损脑细胞的骨髓细胞并激活内源性中枢神经系统干细胞以分化成神经元的步骤。 还提供了治疗脑损伤或脊髓细胞的方法，包括在受损的脑细胞附近移植骨髓细胞并在移植位置产生新的神经元的步骤。 用MSC和神经球的复合物治疗损伤的脑或脊髓细胞的方法。

    Measurement of liquid flows in a living organism
    5.
    发明授权
    Measurement of liquid flows in a living organism 失效
    测量活体中的液体流量

    公开(公告)号：US5305751A

    公开(公告)日：1994-04-26

    申请号：US893503

    申请日：1992-06-04

    申请人： Michael Chopp ,  John Moran ,  Norman Tepley

    发明人： Michael Chopp ,  John Moran ,  Norman Tepley

    IPC分类号： A61B5/0265 ,  A61B5/0275 ,  A61B5/05 ,  A61B5/026

    CPC分类号： A61B5/0265 ,  A61B5/0275 ,  A61B5/05

    摘要： A method of measuring liquid flows in a living organism comprises the steps of applying an applied magnetic field to a living organism, introducing a time-varying quantity of a magnetizable fluid into a flow of liquid in the living organism, and measuring the variation in an induced magnetic field emanating from the living organism as a measure of the flow of the magnetizable fluid and the liquid within the living organism. The measurement of the induced magnetic field is preferably accomplished with at least two magnetic field sensors positioned at different locations relative to the living organism, whose outputs are detected with SQUID detectors. A cross correlation of the outputs of the magnetic field sensors permits the flow of liquid to be deduced as a function of time and location.

    摘要翻译： 一种测量生物体中的液体流动的方法包括以下步骤：将施加的磁场施加到生物体，将可变化量的可磁化流体引入生物体中的液体流中，并测量其中的变化 作为生物体内的可磁化流体和液体的流动的量度，从活体发出的诱发磁场。 诱导磁场的测量优选地通过位于相对于活体的不同位置处的至少两个磁场传感器完成，其输出用SQUID检测器检测。 磁场传感器的输出的相互关系允许根据时间和位置推导出液体的流动。

    COMPOSITIONS AND METHODS FOR USING STROMAL CELLS TO ENHANCE TREATMENT OF CENTRAL NERVOUS SYSTEM INJURIES
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR USING STROMAL CELLS TO ENHANCE TREATMENT OF CENTRAL NERVOUS SYSTEM INJURIES 审中-公开
    使用结构细胞加强中枢神经系统损伤治疗的组合物和方法

    公开(公告)号：US20110158969A1

    公开(公告)日：2011-06-30

    申请号：US12920277

    申请日：2009-02-24

    申请人： Michael Chopp

    发明人： Michael Chopp

    IPC分类号： A61K35/28 ,  A61K35/12 ,  A61P25/28

    CPC分类号： A61K35/28 ,  A61K9/0019 ,  A61K35/407 ,  A61K35/44 ,  A61K47/26

    摘要： The present invention provides novel methods and compositions for the treatment of injuries to the mammalian central nervous system. These methods involve administering stromal cells in combination with a blood-brain barrier permeabilizing agent in order to enhance neurorestoration, functional neurological recovery, stromal cell engraftment, and treatment of neurodegenerative diseases.

    摘要翻译： 本发明提供了用于治疗哺乳动物中枢神经系统损伤的新颖方法和组合物。 这些方法包括与血脑屏障渗透剂组合施用基质细胞，以增强神经复发，功能性神经恢复，基质细胞移植和神经变性疾病的治疗。

    Bone marrow transplantation for treatment of stroke
    8.
    发明申请
    Bone marrow transplantation for treatment of stroke 审中-公开
    骨髓移植治疗中风

    公开(公告)号：US20050169896A1

    公开(公告)日：2005-08-04

    申请号：US11027881

    申请日：2004-12-30

    申请人： Yi Li ,  Michael Chopp

    发明人： Yi Li ,  Michael Chopp

    IPC分类号： A61K35/28 ,  A61K45/00

    CPC分类号： A61K35/28

    摘要： The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of stromal cells for the treatment of neural injury (stroke, traumatic brain injury, spinal cord injury) and neurodegeneration (i.e. Parkinson's disease).

    摘要翻译： 本发明涉及神经损伤和神经变性疾病的治疗。 本发明还包括使用基质细胞治疗神经损伤（中风，创伤性脑损伤，脊髓损伤）和神经变性（即帕金森病）。

    Materials from bone marrow stromal cells for use in forming blood vessels and producing angiogenic and trophic factors
    9.
    发明申请
    Materials from bone marrow stromal cells for use in forming blood vessels and producing angiogenic and trophic factors 审中-公开
    用于形成血管并产生血管生成和营养因子的骨髓基质细胞的材料

    公开(公告)号：US20050158397A1

    公开(公告)日：2005-07-21

    申请号：US10502723

    申请日：2003-01-14

    申请人： Michael Chopp ,  Yi Li ,  Xiaoguang Chen

    发明人： Michael Chopp ,  Yi Li ,  Xiaoguang Chen

    IPC分类号： A61K35/00 ,  A61K35/12 ,  A61K35/30 ,  A61K38/17 ,  A61K38/18 ,  C12N5/0775 ,  C12P21/04

    CPC分类号： A61K38/18 ,  A61K35/28 ,  A61K35/30 ,  C12N5/0618 ,  C12N5/0663 ,  C12N2500/84 ,  C12N2506/1353 ,  A61K2300/00

    摘要： A therapeutic for use in inducing angiogenesis and vasculogenesis, the therapeutic including angiogenesis and vasculogenesis inducing factors isolated from stem cells in conjunction with a pharamaceutically acceptable cell therapy. A method of amplifying the production of angiogenesis and vasculogenesis inducing factors secreted by exposing stem cells to and co-culturing the stem cells with a compound for increasing the production of angiogenesis and vasculogenesis inducing factors. Angiogenesis and vasculogenesis inducing factors isolated and purified from stem cells for use in a therapy. A process for obtaining the angiogenesis and vasculogenesis inducing factors as set forth above, the process including the steps of isolating and purifying human mesenchymal stem cells from tissue prior to differentiation and then culture expanding the mesenchymal stem cells to produce a tool for neurological and musculoskeletal therapy. Isolated and culture expanded mesenchymal stem cells under the influence of a requisite compound, that are capable of differentiating and producing a desired cell phenotype needed for tissue repair.

    摘要翻译： 用于诱导血管发生和血管发生的治疗剂，包括血管生成和血管发生诱导因子，其与药物可接受的细胞疗法联合从干细胞分离。 扩增血管发生和血管发生诱导因子的产生的方法，其通过用用于增加血管生成和血管发生诱导因子的产生的化合物将干细胞暴露于干细胞并共培养干细胞而分泌。 血管生成和血管生成诱导因子从干细胞中分离和纯化用于治疗。 一种用于获得如上所述的血管生成和血管发生诱导因子的方法，该方法包括以下步骤：在分化之前从组织中分离和纯化人间充质干细胞，然后培养扩展间充质干细胞以产生用于神经和肌肉骨骼疗法的工具 。 在必需化合物的影响下分离和培养的扩增的间充质干细胞，其能够分化并产生组织修复所需的所需细胞表型。