专利检索 ap:("Michael F. Tweedle" OR "Hong Fan" OR "Luciano Lattuada" OR "Kondareddiar Ramalingam" OR "Rolf E. Swenson") AND inv:"Hong Fan" 第 1 页

1.

发明申请
Compounds Useful as Metal Chelators 审中-公开
标题翻译：可用作金属螯合剂的化合物

公开(公告)号：US20080124270A1

公开(公告)日：2008-05-29

申请号：US10584430

申请日：2004-12-20

申请人： Michael F. Tweedle , Hong Fan , Luciano Lattuada , Kondareddiar Ramalingam , Rolf E. Swenson

发明人： Michael F. Tweedle , Hong Fan , Luciano Lattuada , Kondareddiar Ramalingam , Rolf E. Swenson

IPC分类号： A61K51/00 , C07D255/02 , A61P43/00 , A61B5/055

CPC分类号： C07D257/02 , A61K51/0482

摘要： New compounds are provided that may be used to chelute a metal. The compound comprise polyazamacrocyclic compound with at least one phosphonic group substituted on at least one of the aza groups of the polyazamacrocyclic compound. Methods for preparing the compounds are also provided. Methods for preparing a diagnostic imaging agent using the compounds and methods for diagnostic imaging are further provided. Methods for preparing a therapeutic agent using the compounds and methods for therapy are further provided.

摘要翻译： 提供了可用于螯合金属的新化合物。该化合物包括在多氮杂环辛基化合物的至少一个氮杂基团上被至少一个膦酸基取代的多氮杂环化合物。还提供了制备化合物的方法。还提供了使用该化合物的诊断成像剂的制备方法和诊断成像方法。还提供了使用该化合物制备治疗剂的方法和治疗方法。

2.

发明申请
KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用

公开(公告)号：US20110097275A1

公开(公告)日：2011-04-28

申请号：US12898119

申请日：2010-10-05

申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan

发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan

IPC分类号： A61K49/22 , A61P35/00

CPC分类号： A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽，特别是造影剂的二聚体和多聚体构建体。还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病（例如癌症）的治疗方案的治疗有效性的方法。

3.

发明授权
Multivalent constructs for therapeutic and diagnostic applications 有权
标题翻译：用于治疗和诊断应用的多价结构

公开(公告)号：US08663603B2

公开(公告)日：2014-03-04

申请号：US12888736

申请日：2010-09-23

申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield

发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield

IPC分类号： A61B8/00

CPC分类号： C07K7/08 , A61K47/60 , A61K47/64 , C07K7/64

摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.

摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。

4.

发明授权
KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用

公开(公告)号：US08623822B2

公开(公告)日：2014-01-07

申请号：US12898119

申请日：2010-10-05

申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan

发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan

IPC分类号： C07K14/00

CPC分类号： A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58

摘要： The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽，特别是造影剂的二聚体和多聚体构建体。还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病（例如癌症）的治疗方案的治疗有效性的方法。

5.

发明授权
Multivalent constructs for therapeutic and diagnostic applications 有权
标题翻译：用于治疗和诊断应用的多价结构

公开(公告)号：US07910088B2

公开(公告)日：2011-03-22

申请号：US11688968

申请日：2007-03-21

申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan

发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield , Feng Yan

IPC分类号： A61B8/00

CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411

摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.

摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。

6.

发明授权
Multivalent constructs for therapeutic and diagnostic applications 失效
标题翻译：用于治疗和诊断应用的多价结构

公开(公告)号：US07261876B2

公开(公告)日：2007-08-28

申请号：US10661032

申请日：2003-09-11

申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield

发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield

IPC分类号： A61K49/00

CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411

摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.

摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。

7.

发明授权
KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用

公开(公告)号：US08642010B2

公开(公告)日：2014-02-04

申请号：US12480578

申请日：2009-06-08

申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski

发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski

IPC分类号： A61K49/00 , A61B8/00

CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58

摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。