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    Method and arrangement for the online regulation of a batch process in a bioreactor
    3.
    发明授权
    Method and arrangement for the online regulation of a batch process in a bioreactor 有权
    在线调节生物反应器中的分批过程的方法和布置

    公开(公告)号：US08078322B2

    公开(公告)日：2011-12-13

    申请号：US11661058

    申请日：2005-08-23

    申请人： Herbert Grieb ,  Karl-Heinz Kirchberg ,  Edmund Linzenkirchner ,  Ingrid Maes ,  Bernd-Markus Pfeiffer

    发明人： Herbert Grieb ,  Karl-Heinz Kirchberg ,  Edmund Linzenkirchner ,  Ingrid Maes ,  Bernd-Markus Pfeiffer

    IPC分类号： G06F13/02 ,  C12Q3/00

    CPC分类号： G05B13/021 ,  C02F3/006

    摘要： The invention relates to the online regulation of a batch process in a bioreactor. According to the invention, spectra of the actual charge in the bioreactor are recorded at successive points during the running batch process. A measuring vector is produced, for each spectrum, in the low-dimensional main constituent region by the main constituent analysis of the high-dimensional spectra. The deviation is calculated between the measuring vector and a corresponding vector of a nominal trajectory consisting of measuring vectors of a reference charge, which are determined in an earlier batch process, and at least one adjustment operation for the batch process is determined and carried out according to said deviation. The direction of the adjustment operation is maintained when the deviation determined from one point to the next decreases, and modified when the deviation determined from one point to the next remains the same or increases.

    摘要翻译： 本发明涉及在生物反应器中的批处理过程的在线调节。 根据本发明，生物反应器中的实际电荷的光谱在运行批处理过程中的连续点记录。 通过高维谱的主要成分分析，在低维主要构成区域中，针对每个光谱产生测量矢量。 在测量矢量和由较早批次处理中确定的参考电荷的测量矢量组成的标称轨迹的对应矢量之间计算出偏差，并且根据以下步骤确定并执行用于批处理的至少一个调整操作 到偏差。 当从一个点到下一个点确定的偏差减小时，保持调整操作的方向，并且当从一个点到下一个点确定的偏差保持相同或增加时修改。

    Method and Arrangement For the Online Regulation of a Batch Process in a Bioreactor
    4.
    发明申请
    Method and Arrangement For the Online Regulation of a Batch Process in a Bioreactor 有权
    生物反应器中批处理的在线调节方法和布置

    公开(公告)号：US20080133044A1

    公开(公告)日：2008-06-05

    申请号：US11661058

    申请日：2005-08-23

    申请人： Herbert Grieb ,  Karl-Heinz Kirchberg ,  Edmund Linzenkirchner ,  Ingrid Maes ,  Bernd-Markus Pfeiffer

    发明人： Herbert Grieb ,  Karl-Heinz Kirchberg ,  Edmund Linzenkirchner ,  Ingrid Maes ,  Bernd-Markus Pfeiffer

    IPC分类号： G06F17/00 ,  C02F3/00 ,  G05D27/00

    CPC分类号： G05B13/021 ,  C02F3/006

    摘要： The invention relates to the online regulation of a batch process in a bioreactor. According to the invention, spectra of the actual charge in the bioreactor are recorded at successive points during the running batch process. A measuring vector is produced, for each spectrum, in the low-dimensional main constituent region by the main constituent analysis of the high-dimensional spectra. The deviation is calculated between the measuring vector and a corresponding vector of a nominal trajectory consisting of measuring vectors of a reference charge, which are determined in an earlier batch process, and at least one adjustment operation for the batch process is determined and carried out according to said deviation. The direction of the adjustment operation is maintained when the deviation determined from one point to the next decreases, and modified when the deviation determined from one point to the next remains the same or increases.

    摘要翻译： 本发明涉及在生物反应器中的批处理过程的在线调节。 根据本发明，生物反应器中的实际电荷的光谱在运行批处理过程中的连续点记录。 通过高维谱的主要成分分析，在低维主要构成区域中，针对每个光谱产生测量矢量。 在测量矢量和由较早批次处理中确定的参考电荷的测量矢量组成的标称轨迹的对应矢量之间计算出偏差，并且根据以下步骤确定并执行用于批处理的至少一个调整操作 到偏差。 当从一个点到下一个点确定的偏差减小时，保持调整操作的方向，并且当从一个点到下一个点确定的偏差保持相同或增加时修改。

    Development system for process control systems as well as associated method and computer program product
    5.
    发明申请
    Development system for process control systems as well as associated method and computer program product 失效
    过程控制系统开发系统以及相关方法和计算机程序产品

    公开(公告)号：US20060190098A1

    公开(公告)日：2006-08-24

    申请号：US11315389

    申请日：2005-12-22

    申请人： Dirk Abel ,  Hubert Bellm ,  Ulrich Epple ,  Herbert Grieb ,  Ansgar Munnemann ,  Philipp Orth ,  Bernd-Markus Pfeiffer ,  Gerd-Ulrich Spohr

    发明人： Dirk Abel ,  Hubert Bellm ,  Ulrich Epple ,  Herbert Grieb ,  Ansgar Munnemann ,  Philipp Orth ,  Bernd-Markus Pfeiffer ,  Gerd-Ulrich Spohr

    IPC分类号： G05B11/01 ,  G05B19/42

    CPC分类号： G05B19/042 ,  G05B19/0421 ,  G05B2219/23304 ,  G05B2219/25229 ,  Y02P90/265

    摘要： The invention relates to methods and devices for developing programs for process control systems and in particular for mathematically intensive or, as the case may be, mathematically complex programs of said kind. According to the prior art programs of said kind were written in a separate development environment and subsequently the developed algorithm was re-implemented using a programming language available for the process control system and the associated compiler. The programming and testing were consequently both time-intensive and prone to error. It is proposed to split the overall algorithm into two parts when programming programs of said kind, a) the actual control algorithm by means of which the mathematical functionality of a controller is provided, and b) the algorithm by means of which the process control system-specific functionality of the above controller is provided. The second algorithm referred to runs in the process-oriented component of the process control system and the actual control algorithm in a computer suitable for industrial application. In order to control the process the two algorithms exchange data, the decision-making authority remaining at the control system level.

    摘要翻译： 本发明涉及用于开发用于过程控制系统的程序的方法和装置，特别是用于数学上密集的（或者视情况而定）所述种类复杂的程序。 根据所述类型的现有技术程序被写在单独的开发环境中，随后使用可用于过程控制系统和相关编译器的编程语言重新实现开发的算法。 编程和测试因此是时间密集的并且容易出错。 提出在所有种类的程序编程时将整体算法分为两部分，a）提供控制器的数学功能的实际控制算法，以及b）使用该过程控制系统的算法 提供了上述控制器的特定功能。 第二种算法称为过程控制系统的面向过程的组件和适用于工业应用的计算机中的实际控制算法。 为了控制过程中的两种算法交换数据，决策权力保留在控制系统层面。

    Method for the wear-minimized operation of installation components
    6.
    发明申请
    Method for the wear-minimized operation of installation components 审中-公开
    安装部件的磨损最小化操作方法

    公开(公告)号：US20100090795A1

    公开(公告)日：2010-04-15

    申请号：US12311268

    申请日：2006-09-28

    申请人： Herbert Grieb ,  Peter Müller ,  Bernd-Markus Pfeiffer ,  Robert Schwab

    发明人： Herbert Grieb ,  Peter Müller ,  Bernd-Markus Pfeiffer ,  Robert Schwab

    IPC分类号： G05B23/02

    CPC分类号： G05B19/404 ,  E05F15/603 ,  E05Y2400/45 ,  E05Y2400/52 ,  E05Y2800/422 ,  G05B2219/41367 ,  G05B2219/50308

    摘要： A method for wear-minimized operation of a component of an installation and a corresponding installation are disclosed. A sensor for state identification is associated with the component and transmits a sensor signal to an evaluation unit. The evaluation unit checks the sensor signal to ascertain whether a wear-promoting operating state is present, and in the event of the presence of such an operating state the component is driven such that a change in the operating state in favor of an operating state with less wear takes place. If, for example, a component is operated at its resonant frequency, it is ensured that the component is operated at a slightly different rotation speed, at which far less severe oscillations occur.

    摘要翻译： 公开了一种用于装置的部件的磨损最小化操作和相应的安装的方法。 用于状态识别的传感器与部件相关联，并将传感器信号传送到评估单元。 评估单元检查传感器信号以确定是否存在磨损促进操作状态，并且在存在这样的操作状态的情况下，驱动部件使得操作状态的改变有利于操作状态， 发生较少的磨损。 例如，如果组件以其谐振频率工作，则确保组件以稍微不同的旋转速度操作，在该旋转速度下发生远不太严重的振荡。

    Development system for process control systems as well as associated method and computer program product
    7.
    发明授权
    Development system for process control systems as well as associated method and computer program product 失效
    过程控制系统开发系统以及相关方法和计算机程序产品

    公开(公告)号：US07349748B2

    公开(公告)日：2008-03-25

    申请号：US11315389

    申请日：2005-12-22

    申请人： Dirk Abel ,  Hubert Bellm ,  Ulrich Epple ,  Herbert Grieb ,  Ansgar Münnemann ,  Philipp Orth ,  Bernd-Markus Pfeiffer ,  Gerd-Ulrich Spohr

    发明人： Dirk Abel ,  Hubert Bellm ,  Ulrich Epple ,  Herbert Grieb ,  Ansgar Münnemann ,  Philipp Orth ,  Bernd-Markus Pfeiffer ,  Gerd-Ulrich Spohr

    IPC分类号： G05B19/42 ,  G06F3/048

    CPC分类号： G05B19/042 ,  G05B19/0421 ,  G05B2219/23304 ,  G05B2219/25229 ,  Y02P90/265

    摘要： The invention relates to methods and devices for developing programs for process control systems and in particular for mathematically intensive or, as the case may be, mathematically complex programs of said kind. According to the prior art programs of said kind were written in a separate development environment and subsequently the developed algorithm was re-implemented using a programming language available for the process control system and the associated compiler. The programming and testing were consequently both time-intensive and prone to error. It is proposed to split the overall algorithm into two parts when programming programs of said kind, a) the actual control algorithm by means of which the mathematical functionality of a controller is provided, and b) the algorithm by means of which the process control system-specific functionality of the above controller is provided. The second algorithm referred to runs in the process-oriented component of the process control system and the actual control algorithm in a computer suitable for industrial application. In order to control the process the two algorithms exchange data, the decision-making authority remaining at the control system level.

    摘要翻译： 本发明涉及用于开发用于过程控制系统的程序的方法和装置，特别是用于数学上密集的（或者视情况而定）所述种类复杂的程序。 根据所述类型的现有技术程序被写在单独的开发环境中，并且随后使用可用于过程控制系统和相关编译器的编程语言重新实现开发的算法。 编程和测试因此是时间密集的并且容易出错。 提出在所有种类的程序编程时将整体算法分为两部分，a）提供控制器的数学功能的实际控制算法，以及b）使用该过程控制系统的算法 提供了上述控制器的特定功能。 第二种算法称为过程控制系统的面向过程的组件和适用于工业应用的计算机中的实际控制算法。 为了控制过程中的两种算法交换数据，决策权力保留在控制系统层面。

    Method and Device for Controlling the Fermentation Process
    9.
    发明申请
    Method and Device for Controlling the Fermentation Process 有权
    用于控制发酵过程的方法和装置

    公开(公告)号：US20110039297A1

    公开(公告)日：2011-02-17

    申请号：US12989375

    申请日：2008-04-23

    申请人： Shun Jie Fan ,  Hongwei Yang ,  Jun Feng Jiang ,  Herbert Grieb ,  Yue Zhuo ,  Kurt Bettenhausen

    发明人： Shun Jie Fan ,  Hongwei Yang ,  Jun Feng Jiang ,  Herbert Grieb ,  Yue Zhuo ,  Kurt Bettenhausen

    IPC分类号： C12Q1/06 ,  C12M1/36

    CPC分类号： C12Q1/02 ,  C12M41/46 ,  C12M41/48 ,  C12M43/00 ,  G01N33/5005 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56966

    摘要： A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information to obtain the difference between the state information of the current biological cells and preset target state information, and controlling the feed rate of nutritional solution into the fermenting tank. Real time control of biological fermenting process is thus accomplished based on the state information of the biological cells during fermentation, and the consistency during fermentation is improved. Complicated mathematical modeling and man-made data analysis are not required for the method and device. Real time control of biological fermenting process is accomplished based on a feedback loop with simply calculation, and control delay is not created, and automatic control of cells statement in fermentation is achieved.

    摘要翻译： 一种用于控制发酵过程的方法和装置，其中所述方法包括从发酵罐收集生物细胞的样品，基于收集的样品获得当前生物细胞的状态信息，将当前生物细胞的状态信息与预设 目标状态信息以获得当前生物细胞的状态信息与预设目标状态信息之间的差异，以及控制营养液进入发酵罐的进料速率。 基于发酵过程中生物细胞的状态信息，实现了生物发酵过程的实时控制，提高了发酵过程中的一致性。 方法和设备不需要复杂的数学建模和人为数据分析。 生物发酵过程的实时控制是通过简单计算的反馈回路实现的，控制延迟不会产生，实现发酵过程中细胞声明的自动控制。

    Method and Arrangement for Optimized Maintenance of Components
    10.
    发明申请
    Method and Arrangement for Optimized Maintenance of Components 审中-公开
    组件优化维护的方法和布置

    公开(公告)号：US20090112672A1

    公开(公告)日：2009-04-30

    申请号：US11922582

    申请日：2005-06-30

    申请人： Hartmut Flämig ,  Herbert Grieb ,  Holger Rachut

    发明人： Hartmut Flämig ,  Herbert Grieb ,  Holger Rachut

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/06 ,  G06Q10/0631 ,  G06Q10/20 ,  G06Q30/0283

    摘要： A method for optimizing the availability of a technical object, comprises the steps of providing a serviceable technical object; defining a service plan; defining a setpoint availability; maintaining the serviceable technical object according to the service plan; determining the actual availability of the serviceable technical object; and automatically adjusting the service plan according to a difference between the setpoint availability and the actual availability.

    摘要翻译： 一种用于优化技术对象的可用性的方法，包括以下步骤：提供可服务的技术对象; 定义服务计划; 定义设定点可用性; 根据服务计划维护可服务的技术对象; 确定可服务的技术对象的实际可用性; 并根据设定值可用性与实际可用性之间的差异自动调整服务计划。