公开(公告)号：US5534226A

公开(公告)日：1996-07-09

申请号：US424063

申请日：1995-04-19

申请人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino

发明人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino

IPC分类号： G01N33/49 ,  G01N33/86 ,  G01N37/00

CPC分类号： G01N33/4905 ,  G01N33/86 ,  Y10T436/10

摘要： A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined device of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing consol agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

摘要翻译： 一种用于对患者血液进行凝血测试的便携式装置。 首先使用刺血针从患者抽血。 然后将血液供应到放置在测试装置内的一次性比色皿。 血液被吸入比色皿内的多个管道。 每个管道含有由血液再水合的干燥或冻干的活化剂。 然后，每个导管中的血液往复运动跨越限制区域，直到发生凝固的预定装置。 由于在多个管道中监测凝固时间，因此可以确定给定样品的凝固时间。 在至少一个导管中存在归一化控制剂。 归一化调理剂抵消血液样品中存在的抗凝血剂的任何影响，从而允许血液样品具有大致正常的凝血特性。 与未处理的血液同时测试归一化的血液，以提供参考值，可以判断测试系统的功能和样品的质量。

公开(公告)号：US5591403A

公开(公告)日：1997-01-07

申请号：US617296

申请日：1996-03-18

申请人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

发明人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

IPC分类号： G01N33/49 ,  G01N33/86 ,  G01N37/00

CPC分类号： G01N33/4905 ,  G01N33/86 ,  Y10T436/10

摘要： A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

摘要翻译： 一种用于对患者血液进行凝血测试的便携式装置。 首先使用刺血针从患者抽血。 然后将血液供应到放置在测试装置内的一次性比色皿。 血液被吸入比色皿内的多个管道。 每个管道含有由血液再水合的干燥或冻干的活化剂。 每个导管中的血液然后往复运动跨越限制区域，直到发生预定的凝结程度。 由于在多个管道中监测凝固时间，因此可以确定给定样品的凝固时间。 在至少一个导管中存在归一化控制剂。 归一化控制剂抵抗血液样品中存在的抗凝血剂的任何作用，从而允许血液样品具有大致正常的凝血特性。 与未处理的血液同时测试归一化的血液，以提供参考值，可以判断测试系统的功能和样品的质量。

公开(公告)号：US5800781A

公开(公告)日：1998-09-01

申请号：US719779

申请日：1996-09-25

申请人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

发明人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

IPC分类号： G01N33/49 ,  G01N33/86 ,  G01N37/00

CPC分类号： G01N33/4905 ,  G01N33/86 ,  Y10T436/10

摘要： A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

摘要翻译： 一种用于对患者血液进行凝血测试的便携式装置。 首先使用刺血针从患者抽血。 然后将血液供应到放置在测试装置内的一次性比色皿。 血液被吸入比色皿内的多个管道。 每个管道含有由血液再水合的干燥或冻干的活化剂。 每个导管中的血液然后往复运动跨越限制区域，直到发生预定的凝结程度。 由于在多个管道中监测凝固时间，因此可以确定给定样品的凝固时间。 在至少一个导管中存在归一化控制剂。 归一化控制剂抵抗血液样品中存在的抗凝血剂的任何作用，从而允许血液样品具有大致正常的凝血特性。 与未处理的血液同时测试归一化的血液，以提供参考值，可以判断测试系统的功能和样品的质量。

公开(公告)号：US5504011A

公开(公告)日：1996-04-02

申请号：US327320

申请日：1994-10-21

申请人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

发明人： Michael Gavin ,  Catherine M. Cimini ,  Ming Huang ,  Anthony Kuklo, Jr. ,  James A. Mawhirt ,  Eduardo Marcelino ,  Albert Simone

IPC分类号： G01N33/49 ,  G01N33/86 ,  G01N37/00

CPC分类号： G01N33/4905 ,  G01N33/86 ,  Y10T436/10

摘要： A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

摘要翻译： 一种用于对患者血液进行凝血测试的便携式装置。 首先使用刺血针从患者抽血。 然后将血液供应到放置在测试装置内的一次性比色皿。 血液被吸入比色皿内的多个管道。 每个管道含有由血液再水合的干燥或冻干的活化剂。 每个导管中的血液然后往复运动跨越限制区域，直到发生预定的凝结程度。 由于在多个管道中监测凝固时间，因此可以确定给定样品的凝固时间。 在至少一个导管中存在归一化控制剂。 归一化控制剂抵抗血液样品中存在的抗凝血剂的任何作用，从而允许血液样品具有大致正常的凝血特性。 与未处理的血液同时测试归一化的血液，以提供参考值，可以判断测试系统的功能和样品的质量。

公开(公告)号：US5836360A

公开(公告)日：1998-11-17

申请号：US823973

申请日：1997-03-25

申请人： Michael Gavin ,  James A. Mawhirt

发明人： Michael Gavin ,  James A. Mawhirt

IPC分类号： B01L3/00 ,  G01F19/00 ,  B65B1/04 ,  B65B3/04

CPC分类号： B01L3/508 ,  G01F19/00 ,  B01L2200/12 ,  B01L2400/0406

摘要： A volume-control receptacle has a reservoir with a bottom. The reservoir is adapted for receiving a fluid. The receptacle has a plurality of capillaries opening on the reservoir at a specific height above the bottom; the capillaries draw off the excess fluid from the receptacle, thereby leaving a specific amount of fluid in the reservoir. In a preferred embodiment, the volume-control receptacle is adapted for use with a disposable cuvette. The reservoir of the receptacle has a drain at the bottom connected to the cuvette for delivering the fluid to a testing instrument or other final application point. The volume-control receptacle has a lip projecting upward from a promontory of the receptacle. A rib extends downward from the lip to the bottom of the reservoir for guiding the fluid into the reservoir.

摘要翻译： 容积控制容器具有底部的容器。 容器适于接收流体。 容器具有在底部上方的特定高度处在储存器上开口的多个毛细管; 毛细管从容器中排出多余的液体，从而在容器中留下特定量的流体。 在优选实施例中，音量控制插座适于与一次性比色皿一起使用。 容器的储存器在底部具有连接到反应杯的排水口，用于将流体输送到测试仪器或其他最终施加点。 音量控制插座具有从插座的岬向上突出的唇部。 肋条从储存器的唇缘向底部延伸到底部，以将流体引导到储存器中。

公开(公告)号：US5731212A

公开(公告)日：1998-03-24

申请号：US359923

申请日：1994-12-20

申请人： Michael Gavin ,  James A. Mawhirt ,  Donald W. Allen

发明人： Michael Gavin ,  James A. Mawhirt ,  Donald W. Allen

IPC分类号： B01L3/00 ,  G01N21/03 ,  G01N33/487 ,  G01N33/49 ,  G01N35/00 ,  G01N35/08 ,  G01N33/553 ,  G01N33/558

CPC分类号： G01N33/4905 ,  B01L3/502 ,  G01N21/03 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N2021/0346 ,  G01N2035/00514 ,  G01N35/08 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/809

摘要： A cuvette based testing device for use in testing or otherwise analyzing a fluid sample. A cuvette is provided that defines at least one conduit, wherein the fluid sample is introduced into the various conduits. Reagents are disposed within the conduits that are intended to be mixed with the fluid sample. The fluid sample is drawn into the conduits by the force of a pneumatic pump. As the fluid sample contacts the various reagents, the reagents mix with the sample. Mixing is further conducted by moving the fluid sample back and forth across an obstruction in the conduit. The obstruction causes turbulent flow in the fluid sample, thereby mixing the sample with any reagent also present. The conduit is preferably transparent. The fluid sample is brought to a point in the cuvette where it is disposed below a detector. The detector is used to measure a characteristic of the fluid sample such as optical density, nephelometry, fluorescence, chemical luminescence, photoemittions or the like. By knowing the reagents mixed with the sample and measuring one or more characteristics of the fluid sample, the sample can be accurately analyzed for many differing tests.

摘要翻译： 用于测试或以其他方式分析流体样品的基于比色杯的测试装置。 提供了一种限定至少一个导管的比色皿，其中将流体样品引入各种导管中。 试剂被布置在旨在与流体样品混合的导管内。 流体样品通过气动泵的力被吸入管道。 当流体样品接触各种试剂时，试剂与样品混合。 进一步通过使流体样品来回穿过管道中的障碍物来进行混合。 障碍物导致流体样品中的湍流，从而将样品与也存在的任何试剂混合。 导管最好是透明的。 将流体样品带到比色杯中，将其置于检测器下方。 检测器用于测量流体样品的特性，例如光密度，比浊法，荧光，化学发光，光电离等。 通过了解与样品混合的试剂并测量流体样品的一个或多个特性，可以准确分析样品进行许多不同的测试。