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公开(公告)号：US08263624B2
公开(公告)日：2012-09-11
申请号：US12302503
申请日：2007-05-25
申请人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan Heitmeier
发明人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan Heitmeier
IPC分类号： A61K31/44 , A61K31/422 , A61K31/4523 , A61K31/4164 , A61K31/506 , A61K31/5377 , A61K31/5355 , C07D231/12 , C07D401/04 , C07D413/14 , C07D417/12 , C07D419/14
CPC分类号： C07D409/14 , C07D231/12 , C07D413/14
摘要： The invention relates to aryl-substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及芳基取代的杂环，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20100029651A1
公开(公告)日：2010-02-04
申请号：US12302503
申请日：2007-05-25
申请人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan heitmeier
发明人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan heitmeier
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4545 , C07D409/14 , A61P7/02 , A01N1/02
CPC分类号： C07D409/14 , C07D231/12 , C07D413/14
摘要： The invention relates to aryl-substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及芳基取代的杂环，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US08198267B2
公开(公告)日：2012-06-12
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20100298293A1
公开(公告)日：2010-11-25
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/553 , A01N1/02 , A61K31/5377 , A61K31/497 , A61K31/513 , A61K31/454 , A61K31/4439 , C07D413/12 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20110015241A1
公开(公告)日：2011-01-20
申请号：US12301978
申请日：2007-05-25
IPC分类号： A61K31/422 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及取代的杂环，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20100273789A1
公开(公告)日：2010-10-28
申请号：US12668619
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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7.发明申请AMINOACYL PRODRUGS AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR THROMBOEMBOLIC DISORDERS 审中-公开作为血栓性疾病的活性药物成分的氨基酸制剂公开(公告)号：US20110172232A1
公开(公告)日：2011-07-14
申请号：US12668590
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -2-氧代-1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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8.发明授权Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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公开(公告)号：US07498460B2
公开(公告)日：2009-03-03
申请号：US10537623
申请日：2003-11-28
申请人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： C07C229/10
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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公开(公告)号：US06939990B2
公开(公告)日：2005-09-06
申请号：US10469557
申请日：2002-02-18
申请人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61P1/16 , A61K31/195 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/08 , A61P15/10 , A61P15/12 , A61P25/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P29/02 , A61P43/00 , C07B61/00 , C07C227/02 , C07C229/38 , C07C253/30 , C07C255/54 , C07C63/00
CPC分类号： C07C229/38 , C07C2601/14
摘要： The invention relates to compounds of the general formula (I) wherein R1 represents H, halogen, or OCF3; R2 and R3 each represents H or halogen; R4 represents C1-6-alkyl, C3-8-cycloalkyl, CF3, OCF3, F, Cl, OMe, or optionally substituted phenyl; V represents O, CH2O, OCF2, or O—C1-6-alkyl-O; and W represents CH2 or CH2CH2. A process for making such compounds, pharmaceutical compositions containing them, and methods of treatment of various conditions using them are also disclosed and claimed.
摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示H，卤素或OCF 3 N; R 2和R 3各自表示H或卤素; R 4表示C 1-6 - 烷基，C 3-8 - 环烷基，CF 3 - ， - F，Cl，OMe或任选取代的苯基; V表示O，CH 2 O，OCF 2或O-C 1-6烷基-O; W表示CH 2或CH 2 CH 2。 还公开并要求保护这些化合物的方法，含有它们的药物组合物，以及使用它们处理各种条件的方法。
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