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11 条记录 (耗时 0.026 秒)

    Pyromellitic diimides and method of increasing feed efficiency in ruminant animals
    1.
    发明授权
    Pyromellitic diimides and method of increasing feed efficiency in ruminant animals 失效
    均苯四酸二酰亚胺和提高反刍动物饲料效率的方法

    公开(公告)号：US4289784A

    公开(公告)日：1981-09-15

    申请号：US142795

    申请日：1980-04-22

    申请人： Richard J. Bochis ,  Michael H. Fisher ,  Bruce O. Linn

    发明人： Richard J. Bochis ,  Michael H. Fisher ,  Bruce O. Linn

    IPC分类号： A23K1/16 ,  C07D209/48 ,  C07D307/89 ,  C07D487/04 ,  C07D491/04 ,  A61K31/40 ,  C07D209/56

    CPC分类号： C07D209/48 ,  A23K20/137 ,  C07D307/89 ,  C07D487/04 ,  C07D491/04

    摘要： Novel substituted pyromellitic diimides are disclosed wherein the compounds are assymetrically substituted with a variety of substituent groups. Processes for the preparation of such compounds are also disclosed. The novel assymetrically substituted pyromellitic diimides are useful for administration to ruminant animals to increase feed efficiency, shift volatile fatty acid production in the ruminants from acetate with an increase in the more energetically efficient propionate and butyrate and to suppress methane formation in the rumen. Composition and methods of treatment utilizing said compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 公开了新的取代的1,2,4,5-苯四酸二酰亚胺，其中化合物被各种取代基进行组分取代。 还公开了制备这些化合物的方法。 新型的异构取代的均苯四酸二酰亚胺可用于反刍动物的施用，以提高饲料效率，使反刍动物中的挥发性脂肪酸产量从乙酸盐转移，同时增加能量效率较高的丙酸酯和丁酸酯，并抑制瘤胃中的甲烷形成。 还公开了使用所述化合物作为其活性成分的组合物和处理方法。

    Symmetrically substituted pyromellitic diimides as ruminant feed additives
    2.
    发明授权
    Symmetrically substituted pyromellitic diimides as ruminant feed additives 失效
    对称取代的均苯四酸二酰亚胺作为反刍动物饲料添加剂

    公开(公告)号：US4212880A

    公开(公告)日：1980-07-15

    申请号：US954039

    申请日：1978-10-23

    申请人： Michael H. Fisher ,  Peter Kulsa ,  Bruce O. Linn

    发明人： Michael H. Fisher ,  Peter Kulsa ,  Bruce O. Linn

    IPC分类号： A23K1/16 ,  A23K1/18 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D487/04 ,  A23K20/137

    摘要： Symmetrically substituted pyromellic diimides are disclosed wherein the compounds are substituted with a variety of substituent groups. The symmetrically substituted compounds are useful for administration to ruminant animals to increase feed efficiency, shift volatile fatty acid production in the ruminant from acetate with an increase in the more energetically efficient propionate and butyrate and to suppress methane formation in the rumen. Compositions and methods of treatment utilizing said compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 公开了对称取代的均苯四酸二酰亚胺，其中化合物被各种取代基取代。 对称取代的化合物可用于反刍动物的施用以提高饲料效率，使反刍动物中的挥发性脂肪酸产生量从乙酸酯转移，同时增加能量效率更高的丙酸酯和丁酸酯，并抑制瘤胃中的甲烷形成。 还公开了使用所述化合物作为其活性成分的组合物和治疗方法。

    Avermectin derivatives
    6.
    发明授权
    Avermectin derivatives 失效

    公开(公告)号：US4873224A

    公开(公告)日：1989-10-10

    申请号：US197731

    申请日：1988-05-23

    申请人： Bruce O. Linn ,  Helmut Mrozik

    发明人： Bruce O. Linn ,  Helmut Mrozik

    IPC分类号： C07H17/08 ,  A01N43/90 ,  A01N47/34 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P33/00 ,  A61P33/10 ,  C07H19/01

    CPC分类号： C07H19/01 ,  A01N43/90 ,  A01N47/34

    摘要： There are disclosed novel avermectin compounds wherein the 4" or 4' hydroxy group is oxidized to an oxo group and replaced with a semicarbazone, carbonyl- or sulfonyl- hydrazone, hydrazone, or oxime, and optionally reduced to the corresponding semicarbazide, carbonyl- or sulfonyl-hydrazide or hydrazine. The semicarbozones and hydrazones are prepared from the 4" or 4' oxo compound using the corresponding semicarbazides or hydrazines. The compounds have utility as anti-parasitic agents and compounds for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests. Compositions for such uses are also disclosed.

    4-Amino-4-dehydroxy derivatives of efrotomycin and related compounds
    8.
    发明授权
    4-Amino-4-dehydroxy derivatives of efrotomycin and related compounds 失效
    依托霉素及相关化合物的4-氨基-4-脱羟基衍生物

    公开(公告)号：US4515783A

    公开(公告)日：1985-05-07

    申请号：US544350

    申请日：1983-10-24

    申请人： Bruce O. Linn ,  Aino Lusi

    发明人： Bruce O. Linn ,  Aino Lusi

    IPC分类号： C07H17/04 ,  A61K31/71 ,  C07H3/06

    CPC分类号： C07H17/04

    摘要： Compounds of the efrotomycin class having a 4-hydroxy-2-pyridone terminal group are converted into 4-amino-4-dehydroxy compounds. The amino group may be substituted with various substituents. The processes for the preparation of such compounds are also disclosed. The amino derivatives have antimicrobial, and growth promotion properties and compositions for such uses are also disclosed.

    摘要翻译： 具有4-羟基-2-吡啶酮末端基团的自由基类的化合物转化为4-氨基-4-脱羟基化合物。 氨基可以被各种取代基取代。 还公开了制备这些化合物的方法。 氨基衍生物具有抗微生物作用，并且还公开了用于这些用途的生长促​​进性质和组合物。

    Alkylthio alkyl avermectins are active antiparasitic agents
    9.
    发明授权
    Alkylthio alkyl avermectins are active antiparasitic agents 失效
    烷硫基烷基除虫菌素是活性抗寄生虫药

    公开(公告)号：US5229415A

    公开(公告)日：1993-07-20

    申请号：US857035

    申请日：1992-03-24

    申请人： Bruce O. Linn ,  Helmut Mrozik

    发明人： Bruce O. Linn ,  Helmut Mrozik

    IPC分类号： C07D493/22 ,  A01N43/90 ,  A61K31/365 ,  A61P33/00 ,  A61P33/10 ,  C07H19/01

    CPC分类号： C07H19/01

    摘要： Avermectin compounds are substituted at the 4", 4' or 13-postion hydroxy group with an alkylthioalkyl group and are optionally substituted at the other reactive positions of the avermectin molecule. The compounds are prepared by reacting protected avermectins, avermectin monosaccharides or avermectin aglycones with dialkylsulfoxides. The compounds are potent antiparasitic agents and compositions for such uses are also disclosed.

    摘要翻译： 阿维菌素化合物在4'，4'或13位羟基与烷硫基烷基取代，并且在除虫菌素分子的其它反应位置任选被取代。 通过使保护的阿维菌素，除虫菌素单糖或阿维菌素糖苷配基与二烷基亚砜反应制备化合物。 这些化合物是有效的抗寄生虫剂，并且还公开了用于此类用途的组合物。

    Avermectin derivatives
    10.
    发明授权
    Avermectin derivatives 失效
    阿维菌素衍生物

    公开(公告)号：US5023241A

    公开(公告)日：1991-06-11

    申请号：US387207

    申请日：1989-07-31

    申请人： Bruce O. Linn ,  Helmut Mrozik

    发明人： Bruce O. Linn ,  Helmut Mrozik

    IPC分类号： A01N43/90 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P33/00 ,  A61P33/10 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Novel avermectin derivatives are disclosed, wherein the 4"-hydroxy group is replaced by a substituted acylamino or benzoylamino group. These avermectin derivatives can be further derivatized at the 5- and 23-positions as ketoximes or O-substituted ketoximes. The 4"-substituted avermectin derivatives are prepared by the acylation of the known 4"-aminoavermectins with acylating reagents. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.