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公开(公告)号：US20050261268A1
公开(公告)日：2005-11-24
申请号：US10914051
申请日：2004-08-06
申请人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
发明人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
IPC分类号： A61P35/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , A61K31/545 , A61K31/4196 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D501/14 , C07D43/02
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07226920B2
公开(公告)日：2007-06-05
申请号：US10914051
申请日：2004-08-06
申请人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号： A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07598245B2
公开(公告)日：2009-10-06
申请号：US11787165
申请日：2007-04-13
申请人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号： A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120171245A1
公开(公告)日：2012-07-05
申请号：US13327206
申请日：2011-12-15
申请人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann
发明人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann
IPC分类号： A61K39/145 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K31/553 , A01P1/00 , A01N43/90 , C07D491/08 , C07D491/107 , A61P31/16 , A61P37/04 , C07D471/04 , A61K31/55
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D239/30 , C07D401/04 , C07D401/10 , C07D471/04
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中的流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US20160355512A1
公开(公告)日：2016-12-08
申请号：US15177546
申请日：2016-06-09
申请人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/351 , A61K31/215 , A61K31/497 , A61K31/506 , A61K31/444
CPC分类号： C07D471/04 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07F9/6561
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。
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公开(公告)号：US20210040092A1
公开(公告)日：2021-02-11
申请号：US17083569
申请日：2020-10-29
申请人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人： Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , C07F9/6561 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497
摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
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