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公开(公告)号:US07598245B2
公开(公告)日:2009-10-06
申请号:US11787165
申请日:2007-04-13
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07226920B2
公开(公告)日:2007-06-05
申请号:US10914051
申请日:2004-08-06
申请人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
发明人: Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey, Jr. , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/427 , A61K31/5377 , C07D413/12 , C07D263/32 , C07D249/08
CPC分类号: C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物,制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07279469B2
公开(公告)日:2007-10-09
申请号:US10715111
申请日:2003-11-17
申请人: Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人: Albert C. Pierce , Michael Amost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07902239B2
公开(公告)日:2011-03-08
申请号:US11774702
申请日:2007-07-09
申请人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人: Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号: A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377
CPC分类号: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08338412B2
公开(公告)日:2012-12-25
申请号:US13107802
申请日:2011-05-13
申请人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号: C07D487/04 , A61K31/5025
CPC分类号: C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及p38的抑制剂,哺乳动物蛋白激酶涉及细胞增殖,细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号:US07951809B2
公开(公告)日:2011-05-31
申请号:US12062495
申请日:2008-04-03
申请人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号: C07D239/70 , A61K31/519
CPC分类号: C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及p38的抑制剂,哺乳动物蛋白激酶涉及细胞增殖,细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号:US07276502B2
公开(公告)日:2007-10-02
申请号:US10809946
申请日:2004-03-25
申请人: Guy Brenchley , Luc J. Farmer , Edmund M. Harrington , Ronald Knegtel , Michael O'Donnell , Francesco G. Salituro , John R. Studley , Jian Wang
发明人: Guy Brenchley , Luc J. Farmer , Edmund M. Harrington , Ronald Knegtel , Michael O'Donnell , Francesco G. Salituro , John R. Studley , Jian Wang
IPC分类号: C07D417/04 , A61K31/506
CPC分类号: C07D417/14 , C07D417/04
摘要: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20170342102A1
公开(公告)日:2017-11-30
申请号:US15531313
申请日:2015-11-27
申请人: Gabriel Martinez BOTELLA , Boyd L. HARRISON , Albert Jean ROBICHAUD , Francesco G. SALITURO , Richard Thomas BERESIS , Sage Therapeutics, Inc.
发明人: Gabriel Martinez Botella , Boyd L. Harrison , Albert J. Robichaud , Francesco G. Salituro , Richard T. Beresis
摘要: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号:US20170325708A1
公开(公告)日:2017-11-16
申请号:US15589615
申请日:2017-05-08
申请人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
发明人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
IPC分类号: A61B5/055 , G01N33/574 , C12Q1/68 , A61K31/426 , C12Q1/32 , C12N15/113 , A61K45/06 , G06F19/00 , A61K31/41
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
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公开(公告)号:US09303002B2
公开(公告)日:2016-04-05
申请号:US14085947
申请日:2013-11-21
申请人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
发明人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号: C07D285/135 , C07D417/14 , C07D285/12 , C07D417/12 , C07D471/04
CPC分类号: C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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