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公开(公告)号：US07875611B2
公开(公告)日：2011-01-25
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/40 , C07D265/30 , C07D207/04
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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2.发明授权Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics 有权用于心律失常的氨基环烷基肉桂酰胺化合物和作为止痛剂和麻醉剂公开(公告)号：US07687536B2
公开(公告)日：2010-03-30
申请号：US11402228
申请日：2006-04-11
IPC分类号： A61K31/40 , C07D207/04 , C07D207/46
CPC分类号： C07D295/135 , A61K31/40 , C07C2601/08 , C07C2601/14
摘要： Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
摘要翻译： 公开了氨基环烷基肉桂酰胺化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和局部镇痛和麻醉的产生。
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公开(公告)号：US20100029639A1
公开(公告)日：2010-02-04
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/32 , A61K31/5375 , A61K31/40 , C07D207/08 , C07D409/08 , A61P9/00
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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4.发明授权Method and apparatus for operating an electrochemical fuel cell with periodic fuel starvation at the anode 失效用于在阳极处操作具有周期性燃料不足的电化学燃料电池的方法和装置
公开(公告)号：US6096448A
公开(公告)日：2000-08-01
申请号：US998133
申请日：1997-12-23
申请人： David P. Wilkinson , Clarence Y. F. Chow , Derek E. Allan, deceased , by Patricia Joanne Allan, administrator , Erik P. Johannes , Joy A. Roberts , Jean St-Pierre , Cindy J. Longley , John K. K. Chan
发明人： David P. Wilkinson , Clarence Y. F. Chow , Derek E. Allan, deceased , by Patricia Joanne Allan, administrator , Erik P. Johannes , Joy A. Roberts , Jean St-Pierre , Cindy J. Longley , John K. K. Chan
CPC分类号： H01M8/04223 , H01M8/04089 , H01M8/0662 , H01M2300/0082
摘要： A method and apparatus is provided for operating an electrochemical fuel cell with periodic momentary fuel starvation at the anode. It is believed that such momentary periodic fuel starvation conditions cause the anode potential to increase, resulting in the oxidation and removal of electrocatalyst poisons from the anode electrocatalyst and improved fuel cell performance. In a preferred method, while successive localized portions of the fuel cell anode are momentarily periodically fuel starved, the remainder of the fuel cell anode remains electrochemically active and saturated with fuel such that the fuel cell is continually available to generate power.
摘要翻译： 提供一种用于操作在阳极周期性瞬时燃料不足的电化学燃料电池的方法和装置。 据信这种瞬时的周期性燃料不足情况导致阳极电位增加，导致电极催化剂氧化和除去阳极电催化剂并改善燃料电池性能。 在优选的方法中，虽然燃料电池阳极的连续局部部分暂时地周期性地燃料不足，但燃料电池阳极的其余部分保持电化学活性并被燃料饱和，使得燃料电池连续地可用于发电。
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5.发明授权Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics 有权用于心律失常和止痛剂和麻醉剂的氨基环烷基肉桂酰胺化合物公开(公告)号：US07053087B1
公开(公告)日：2006-05-30
申请号：US09914884
申请日：2000-03-03
IPC分类号： A61K31/5375 , C07D295/155
CPC分类号： C07D295/135 , A61K31/40 , C07C2601/08 , C07C2601/14
摘要： Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia. n=1–4; R1, R2, R3, R4, R5, R13, X and A are as in claim (1).
摘要翻译： 公开了氨基环烷基肉桂酰胺化合物（I）。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和局部镇痛和麻醉的产生。 n = 1-4; R 1，R 2，R 3，R 4，R 5， R 13，X和A如权利要求（1）所述。
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公开(公告)号：US07101877B2
公开(公告)日：2006-09-05
申请号：US10674684
申请日：2003-09-29
申请人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
发明人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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9.发明授权Method and apparatus for operating an electrochemical fuel cell with periodic reactant starvation 有权用于操作具有周期性反应物饥饿的电化学燃料电池的方法和装置公开(公告)号：US06472090B1
公开(公告)日：2002-10-29
申请号：US09344763
申请日：1999-06-25
申请人： Kevin Michael Colbow , Marian van der Geest , Cindy J. Longley , Jens Müller , Joy Roberts , Jean St-Pierre , Peter Urban , Regina Wezel , David P. Wilkinson , Jiujun Zhang
发明人： Kevin Michael Colbow , Marian van der Geest , Cindy J. Longley , Jens Müller , Joy Roberts , Jean St-Pierre , Peter Urban , Regina Wezel , David P. Wilkinson , Jiujun Zhang
IPC分类号： H01M804
CPC分类号： H01M8/04753 , H01M8/0267 , H01M8/04223 , H01M8/04679 , H01M8/04925 , H01M8/241 , H01M8/2457 , H01M8/2483 , H01M2300/0082
摘要： An electrochemical fuel cell is operated with periodic reactant starvation at either or both electrodes. Periodic reactant starvation conditions cause a change in the potential of the starved electrode and may result in the removal of electrocatalyst poisons and in improved fuel cell performance. This technique may have other beneficial effects at the electrodes, including performance improvements due to water management effects or localized heating effects at the starved electrode. In a preferred method, while successive localized portions of a fuel cell electrode are periodically reactant starved, the remainder of the fuel cell electrode remains electrochemically active and saturated with reactant such that the fuel cell is able to continue to generate power.
摘要翻译： 电化学燃料电池在电极中的任一个或两个电极处周期性的反应物饥饿运行。 周期性反应物饥饿条件导致饥饿电极的电位发生变化，并可能导致电催化剂毒物的消除和改进的燃料电池性能。 该技术可能在电极处具有其他有益效果，包括由于在饥饿电极处的水管理效应或局部加热效应引起的性能改善。 在优选的方法中，虽然燃料电池电极的连续局部部分周期性地反应性不足，但燃料电池电极的其余部分保持电化学活性并用反应物饱和，使得燃料电池能够继续发电。
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