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    METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES AND COMPOUNDS
    5.
    发明申请
    METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES AND COMPOUNDS 有权
    用于评估前列腺癌治疗和化合物的方法和材料

    公开(公告)号：US20080090888A2

    公开(公告)日：2008-04-17

    申请号：US10590445

    申请日：2006-08-24

    申请人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    发明人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    IPC分类号： A61K31/4166 ,  C07D233/84

    CPC分类号： A61K31/426

    摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.

    摘要翻译： 雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

    Methods and materials for assessing prostate cancer therapies and compounds
    6.
    发明申请
    Methods and materials for assessing prostate cancer therapies and compounds 有权
    用于评估前列腺癌疗法和化合物的方法和材料

    公开(公告)号：US20070191443A1

    公开(公告)日：2007-08-16

    申请号：US10590445

    申请日：2005-02-23

    申请人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    发明人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    IPC分类号： A61K31/4166 ,  C07D233/84

    CPC分类号： A61K31/426

    摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.

    摘要翻译： 雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

    Facilitating processing in a communications environment using stop signaling
    7.
    发明授权
    Facilitating processing in a communications environment using stop signaling 有权
    在通信环境中使用停止信号促进处理

    公开(公告)号：US08880956B2

    公开(公告)日：2014-11-04

    申请号：US13151119

    申请日：2011-06-01

    申请人： Edward W. Chencinski ,  Michael Jung ,  Martin Rehm ,  Philip A. Sciuto

    发明人： Edward W. Chencinski ,  Michael Jung ,  Martin Rehm ,  Philip A. Sciuto

    IPC分类号： G06F11/00

    CPC分类号： H04L41/0654 ,  H04L41/069

    摘要： Processing, such as debug and/or recovery processing, within a communications environment is facilitated. Responsive to detecting an event, a stop signal is propagated through a communications network of the communications environment, and each network element that receives the stop signal, transmits the signal to its neighbors (if any), and then performs an action depending on its specific programming. The action can be to take no action, perform a debugging action or perform a recovery action. The elements that receive the signal and perform the same action as other elements form a coordinated network providing a coordinated result.

    摘要翻译： 促进在通信环境内的处理，例如调试和/或恢复处理。 响应于检测事件，通过通信环境的通信网络传播停止信号，并且接收停止信号的每个网络单元将信号发送到其邻居（如果有的话），然后根据其特定的 编程。 该操作可以不采取任何行动，执行调试操作或执行恢复操作。 接收信号并执行与其他元素相同的动作的元素形成协调的网络，提供协调的结果。

    Method of starting an internal combustion engine, device and controller
    9.
    发明授权
    Method of starting an internal combustion engine, device and controller 有权
    启动内燃机，装置和控制器的方法

    公开(公告)号：US08763580B2

    公开(公告)日：2014-07-01

    申请号：US12812070

    申请日：2008-10-27

    申请人： Horst Belau ,  Michael Jung

    发明人： Horst Belau ,  Michael Jung

    IPC分类号： F02N11/00 ,  F02D41/06 ,  F02P5/15

    CPC分类号： F02N19/005 ,  F02N11/0814 ,  F02N99/004 ,  F02N99/006 ,  F02N2019/007 ,  F02N2019/008

    摘要： In a method for starting an internal combustion engine having at least one cylinder, an inlet and an outlet valve, and having a piston interacting with a crankshaft, and the crankshaft moving in a predetermined rotational direction during normal operation of the internal combustion engine, the piston is located in an initial position, the piston is moved into a defined starting position against a normal rotational direction of the crankshaft by means of a drive, fuel is injected, and the fuel is ignited.

    摘要翻译： 在内燃机的启动方法中，具有至少一个气缸，入口和出口阀，并且具有与曲轴相互作用的活塞，并且所述曲轴在内燃机的正常运行期间沿预定旋转方向运动， 活塞位于初始位置，活塞通过驱动而相对于曲轴的正常旋转方向移动到限定的起始位置，燃料被喷射并且燃料被点燃。

    Switch failover control in a multiprocessor computer system
    10.
    发明授权
    Switch failover control in a multiprocessor computer system 有权
    在多处理器计算机系统中切换故障转移控制

    公开(公告)号：US08677180B2

    公开(公告)日：2014-03-18

    申请号：US12821256

    申请日：2010-06-23

    申请人： Gerd K. Bayer ,  David F. Craddock ,  Thomas A. Gregg ,  Michael Jung ,  Andreas Kohler ,  Elke G. Nass ,  Oliver G. Schlag ,  Peter K. Szwed

    发明人： Gerd K. Bayer ,  David F. Craddock ,  Thomas A. Gregg ,  Michael Jung ,  Andreas Kohler ,  Elke G. Nass ,  Oliver G. Schlag ,  Peter K. Szwed

    IPC分类号： G06F11/00

    CPC分类号： G06F11/2043 ,  G06F11/2033 ,  G06F11/2038

    摘要： A system and a method for failover control comprising: maintaining a primary device table entry (DTE) in a first table activated for a first adapter in communication with a first processor node having a first root complex via a first switch assembly and maintaining a secondary DTE in standby for a second adapter in communication with a second processor node having a second root complex via a second switch assembly; maintaining a primary DTE in a second table activated for the second adapter and maintaining a secondary DTE in standby for the first adapter; and upon a failover, updating the secondary DTE in the first table as an active entry for the second adapter and forming a path to enable traffic to route from the second adapter through the second switch assembly over to the first switch assembly and up to the first root complex of the first processor node.

    摘要翻译： 一种用于故障切换控制的系统和方法，包括：在通过第一交换机组件与具有第一根复合的第一处理器节点通信的第一适配器激活的第一表中维护主设备表条目（DTE），并维护辅助DTE 在待机时通过第二开关组件与具有第二根部复合体的第二处理器节点通信的第二适配器; 在为第二适配器激活的第二表中维持主DTE，并且为第一适配器维持辅助DTE待机; 并且在故障切换时，将所述第一表中的辅助DTE更新为所述第二适配器的活动条目，并形成路径以使流量从所述第二适配器通过所述第二交换机组件路由到所述第一交换机组件，并且直到所述第一适配器 第一个处理器节点的根复合体。