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    NOVEL Bak BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF
    2.
    发明申请
    NOVEL Bak BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF 有权
    新蛋白结合蛋白，编码蛋白的DNA及其使用方法

    公开(公告)号：US20070099215A1

    公开(公告)日：2007-05-03

    申请号：US11539859

    申请日：2006-10-09

    申请人： Michael Kiefer ,  Paul Fitzpatrick ,  Helen Gibson ,  Philip Barr

    发明人： Michael Kiefer ,  Paul Fitzpatrick ,  Helen Gibson ,  Philip Barr

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  G01N2333/47 ,  G01N2500/02 ,  G01N2510/00

    摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.

    摘要翻译： 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。

    Methods of protein production in yeast
    5.
    发明申请
    Methods of protein production in yeast 失效
    酵母中蛋白质生产的方法

    公开(公告)号：US20050084972A1

    公开(公告)日：2005-04-21

    申请号：US10914863

    申请日：2004-08-09

    申请人： Philip Barr ,  Helen Gibson

    发明人： Philip Barr ,  Helen Gibson

    IPC分类号： C07K14/81 ,  C12N15/81 ,  C12N15/74 ,  C12N1/18

    CPC分类号： C12N15/81 ,  C07K14/811 ,  C07K14/8121 ,  C07K14/8125

    摘要： Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons. Host cells are cultured under conditions where, after an initial batch phase, oxygen concentration is kept high and glucose feed is regulated so that the yeast cells stay in respiratory metabolism.

    摘要翻译： 提供载体，宿主细胞和方法用于在酵母中生产蛋白质。 载体通常含有选择基因，酵母2微米序列和编码多肽的多核苷酸，其中多核苷酸可操作地连接至启动子，并且其中多核苷酸含有一个或多个酵母优选的密码子。 在初始分批阶段之后，保持高浓度的氧浓度并调节葡萄糖进料以使酵母细胞保持呼吸代谢的条件下培养宿主细胞。

    MULTIFUNCTIONAL PROTEASE INHIBITORS AND THEIR USE IN TREATMENT OF DISEASE
    6.
    发明申请
    MULTIFUNCTIONAL PROTEASE INHIBITORS AND THEIR USE IN TREATMENT OF DISEASE 失效
    多功能蛋白酶抑制剂及其在治疗疾病中的应用

    公开(公告)号：US20080085854A1

    公开(公告)日：2008-04-10

    申请号：US11781152

    申请日：2007-07-20

    申请人： Philip Barr ,  Helen Gibson ,  Philip Pemberton

    发明人： Philip Barr ,  Helen Gibson ,  Philip Pemberton

    IPC分类号： A61K38/00 ,  C07H21/00 ,  C07K14/00 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K14/811 ,  C07K14/8125 ,  C07K14/8146 ,  C07K2319/00

    摘要： Fusion proteins of protease inhibitors are provided, in particular fusion proteins of alpha 1-antitrypsin (AAT) and a second protease inhibitor, such as secretory leukocyte protease inhibitor (SLPI) or tissue inhibitor of metalloproteases (TIMP). Polynucleotides encoding the fusion proteins, vectors comprising such polynucleotides, and host cells containing such vectors are also provided. Methods of making the fusion proteins of the invention are also provide, as well as methods of using the fusion proteins, for example to inhibit protease activity in a biological sample or in the treatment of an individual suffering from, or at risk for, a disease or disorder involving unwanted protease activity.

    摘要翻译： 提供蛋白酶抑制剂的融合蛋白，特别是α1-抗胰蛋白酶（AAT）和第二蛋白酶抑制剂如分泌白细胞蛋白酶抑制剂（SLPI）或金属蛋白酶组织抑制剂（TIMP）的融合蛋白。 还提供了编码融合蛋白的多核苷酸，包含这种多核苷酸的载体和含有这些载体的宿主细胞。 制备本发明的融合蛋白的方法还提供了使用融合蛋白的方法，例如抑制生物样品中的蛋白酶活性或治疗患有疾病或患有疾病的个体 或涉及不需要的蛋白酶活性的病症。

    Treatment of respiratory disease associated with matrix metalloproteases by inhalation of synthetic matrix metalloprotease inhibitors
    9.
    发明申请
    Treatment of respiratory disease associated with matrix metalloproteases by inhalation of synthetic matrix metalloprotease inhibitors 审中-公开
    通过吸入合成基质金属蛋白酶抑制剂治疗与基质金属蛋白酶相关的呼吸道疾病

    公开(公告)号：US20050107306A1

    公开(公告)日：2005-05-19

    申请号：US10848594

    申请日：2004-05-17

    申请人： Philip Barr ,  Philip Pemberton

    发明人： Philip Barr ,  Philip Pemberton

    IPC分类号： A61K31/00 ,  A61K31/351 ,  A61K31/405 ,  A61K31/46 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61K38/04

    CPC分类号： A61K31/351 ,  A61K31/00 ,  A61K31/405 ,  A61K31/46 ,  A61K2300/00

    摘要： The present invention encompasses methods and compositions for the treatment and prevention of respiratory diseases associated with matrix metalloproteases. More specifically, the present invention relates to the treatment and prevention of respiratory diseases associated with matrix metalloproteases by inhalation of synthetic matrix metalloprotease inhibitors. Exemplary respiratory diseases associated with matrix metalloproteases that may be treated by the methods of the invention include chronic obstructive pulmonary disease, emphysema, asthma, cystic fibrosis, and chronic bronchitis. An exemplary synthetic matrix metalloprotease useful in the methods of the invention is ilomastat.

    摘要翻译： 本发明包括用于治疗和预防与基质金属蛋白酶相关的呼吸道疾病的方法和组合物。 更具体地，本发明涉及通过吸入合成基质金属蛋白酶抑制剂治疗和预防与基质金属蛋白酶相关的呼吸道疾病。 可用本发明方法治疗的基质金属蛋白酶相关的示例性呼吸道疾病包括慢性阻塞性肺病，肺气肿，哮喘，囊性纤维化和慢性支气管炎。 可用于本发明方法的示例性合成基质金属蛋白酶是伊洛司特（ilomastat）。